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Reproductive Sciences Journal Club

Reproductive Sciences Journal Club is held once or twice a month on Fridays from 12:30 - 1:30 pm in the RC2 3rd floor conference room (P15-3015), unless otherwise noted.

Our journal club includes a thorough presentation of the selected article and lively discussion and critique. Light lunch is provided. Students and others affiliated​ with the Division of Reproductive Sciences lead the sessions with faculty, post doc, and staff participation. Article titles and PubMed ID's are given below.

For additional information, or to volunteer for a presentation, suggest a speaker, or request an article, please contact:

Jenifer Monks, PhD​, Reproductive Sciences Journal Club Director. 

Nicole Solazzo​, Reproductive Sciences Journal Club Coordinator. Office: (303) 724-3506

Sponsored by the Department of Obstetrics & Gynecology and the Division of Reproductive Sciences​

​​Date ​Presenter ​Paper Citation
​11/16/2018 ​Diane Gumina J. Cell Biol. 2017 Oct 2; 216(10):3355-3368

A molecular signature for anastasis, recovery from the brink of apoptotic cell death.

Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HR, Kosik KS, Montell DJ.

​12/21/2018 ​Shuhan Ji, PhD

Cell Rep. 2018 Jun 19;23(12):3635-3646.

Full Functional Knockout of Placental Growth Factor by Knockin with an Inactive Variant Able to Heterodimerize with VEGF-A.

Apicella I, Cicatiello V, Acampora D, Tarallo V, De Falco S.

​2/1/2019 ​Elena Silva, PhD ​Nat Commun. 2018 May 2;9(1):1763

P53 and m TOR Signaling Determine Fitness Selection Through Cell Competition During Early Mouse Embryonic Development.

Bowling S, Di Gregorio A, Sancho M, Pozzi S, Aarts M, Signore M, D Schneider M, Martinez-Barbera JP, Gil J, Rodriguez TA.

​2/15/2019 Brandon Sawyer, MD
Nat Med. 2011 Oct 30;17(11):1498-503

Adipocytes Promote Ovarian Cancer Metastatis and Provide Energy for Rapid Tumor Growth

Nieman, KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E.

​4/19/2019​ ​Allie McMellen ​Cancer Cell. 2019 Mar 18;35(3):519-533.e8

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS

​5/17/2019 ​​Cassie Roeca, MD Sci Rep. 2019 Apr 30;9(1):6694

The Transgenerational Effects of Oocyte Mitochondrial Supplementation

St John JC, Makanji Y, Johnson JL, Tsai TS, Lagondar S, Rodda F, Sun X, Pangestu M, Chen P, Temple-Smith P

​​Date ​Presenter ​Paper Citation
​10/20/2017​ ​Kristy Howell J Neurosci.2016 Jun 1;36(22):6041-9.
Maternal Inflammation Disrupts Fetal Neuro-development via Increased Placental Output of Serotonin to the Fetal Brain.
Goeden N, Velasquez J, Arnold KA, Chan Y, Lund BT, Anderson GM, Bonnin A.
​11/17/2017 ​Levi Watson ​Nat Commun. 2017 Oct 23. doi: 10.1038/s41467-017-00962-1. PMCID: PMC5653668
High Grade Serous Ovarian Carcinomas Originate in the Fallopian Tube.
S. Intidhar Labidi-Galy, Eniko Papp, Dorothy Hallberg, Noushin Niknafs, Vilmos Adleff, et al.
​12/15/2017 ​Owen Vaughan ​Science. 2017 Aug 18; 357(6352): 707-713
ELABELA Deficiency Promotes Preeclampsia and Cardiovascular Malformations in Mice.
Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B.
​1/19/2018 ​Mira Estin FASEB J. 2015 Feb; 29(2):636-49.
Macrophage Polarization Phenotype Regulates Adiponectin Receptor Expression and Adiponectin Anti-Inflammatory Response.
van Stijn CM, Kim J, Lusis AJ, Barish GD, Tangirala RK.
​2/16/2018 ​Lindsay Wheeler Nat Commun. 2017 Aug 28; 8(1):365.
Systems Analysis of Apoptic Priming in Ovarian Cancer Identifies Vulnerabilities and Predictors of Drug Response.
Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS.
​3/16/2018 ​Natalie Hohos Nat Genet. 2018 Feb 19.
Embryonic Defects Induced by Maternal Obesity in Mice Derive from Stella Insufficiency in Oocytes.
Han L, Ren C, Li L, Li X, Ge J, Wang H, Miao YL, Guo X, Moley KH, Shu W, Wang Q.
​4/20/2018 ​Damian Guerra ​Nitric Oxide. 2018 May 1;75:85-94.
The Production of Nitric Oxide in the Coeliac Ganglion Modulates the Effect of Cholinergic Neurotransmission on the Rat Ovary During the Preovulatory Period.
Delsouc MB, Della Vedova MC, Ramirez D, Delgado SM, Casais M.
​5/18/2018 ​Laura James-Allan Hypertension. 2017 Aug;70(2):372-381.
Placental Vesicles Carry Active Endothelial Nitric Oxide Synthase and Their Activity is Reduced in Preeclampsia.
Motta-Mejia C, Kandzija N, Zhang W, Mhlomi V, Cerdeira AS, Burdujan A, Tannetta D, Dragovic R, Sargent IL, Redman CW, Kishore U, Vatish M.


​​Date ​Presenter ​Paper Citation
​10/21/2016 ​Allyson Roof
​E​ndocrinology. 2016 Jul;157(7):2686-97. doi: 10.1210/en. 2016-1080. Epub 2016 May 4.
Genomic Effect of Triclosan on the Fetal Hypthalamus: Evidence for Altered Neuropeptide Regulation.
Rabaglino MB, Chang EI, Richards EM, James MO, Keller-Wood M, Wood CE.
​11/18/2016 ​Damian Guerra Hypertension. 2015 Dec;66(6):1191-8.
Hypothalamic Paraventricular and Arcuate Nuclei Contribute to Elevated Sympathetic Nerve Activity in Pregnant Rats: Role of Neuropeptide Y and α-Melanocyte-Stimulating Hormone.
Shi Z, Cassaglia PA, Gotthardt LC, Brooks VL.
PMID: 26483343​​
​01/20/2017 ​Amin Ramzan ​JAMA Oncol. 2016 Nov 1;2(11):1434-1440.
Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations.
Shu CA, Pike MC, Jotwani AR, Friebel TM, Soslow RA, Levine DA, Nathanson KL, Konner JA, Arnold AG, Bogomolniy F, Dao F, Olvera N, Bancroft EK, et al.
PMID: 27367496​
​02/17/2017 ​Taylor Soderborg J Cell Physiol. 2017 Feb 4. doi: 10.1002/jcp.25845.
IL-10 Expression in Macrophages from Neonates Born from Obese Mothers is Suppressed by IL-4 and LPS/INFγ.
Cifuentes-Zúñiga F, Arroyo-Jousse V, Soto-Carrasco G, Casanello P, Uauy R, Krause BJ, Castro-Rodríguez​ JA.
PMID: 28160500​
​04/21/2017 ​Sydney Coates ​Sci Rep. 2016 Oct 17;6:35536. doi: 10.1038/srep35536.
MicroRNA-16 inhibits eto-maternal angiogenesis and causes recurrent spontaneous abortion by targeting vascular endothelial growth factor.
Zhu Y. Lu H, Huo Z, Ma Z, Dang J, Pan L, Chen J, Zhong H.
PMID: 27748453​
​Michael Oliphant
​​Nat Commun. 2017 Apr 25;8:15112. doi:10.1038/ncomms15112.
An extra-uterine system to psychologically support the extreme premature lamb.
Emily Partidge, Marcus Davey, Matthew Hornick, Patrick McGovern, Ali Mejaddam, Jesse Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert Caskey, Theodore Weiland, Jiancheng Han, Alexander Schupper, James Connelly, Kevin Dysart, Jack Rychik, Holly Hedrick, William Peranteau, Alan Flake
PMID: 28440792​
​06/16/2017 ​Trond Michelsen N Engl J Med. 2016 Jan 7;374(1):13-22.
Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
Ziesler H, Llurna E, Chantraine F, Vatish M, Staff AC, Sennstrom M, Olovsson M, Brennecke SP, Stepan H, Allegtranza D, Dilba P, Schoedl M, Hund M, Verohren S.
PMID: 26735990​​

D​ate​​ ​​Presenter​ ​​Paper Citation​
9/18/2015​ Natalia Grindler Fertility and Sterility. 2013 Sep; 100(3):818-24.
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Ruiz-Alonso M1, Besa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.
PMID: 23756099

​10/16/2015 ​Linnea Schmidt Science. 2015 Oct 1. pii:aad0836.
Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.
Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M.
PMID: 26429887

​11/20/2015 ​Chris Breed Nat Commun. 2015 Aug 3;6:7956.
An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer.
Janzen DM, Tiourin E, Salehi JA, Paik DY, Lu J, Pellegrini M, Memarzadeh S.
PMID: 26234182​

​12/18/2015 ​Allyson Roof ​​​Endocrinology. 2015 Aug;156(8):2880-92. doi:10.1210/en.2015-1040.
Hypothalamic Prolactin Regulation of Luteinizing Hormone Secretion in the Female Rat.
Grachev P, Li XF, Goffin V, O'Byrne KT.
PMID: 25993525

2/26/2016​ ​Andrew Libby Cell Stem Cell. 2016 Jan 27. pii:S1934-5909(16)00003-5. doi: 10.1016/j.stem2016.01.002.
Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver.
Sigurdsson V, Takei H, Soboleva S, Radulovic V, Galeev R, Siva K, Leeb-Lunderg LM, Iida T, Nittono H, Miharada K
PMID: 26831518​

​3/25/2016 ​Sydney Coates ​Cell Stem Cell. 2016 Mar 3. pii: S1934-5909(16)00106-5. doi: 10.1016/j.stem.2016.02.016.
Zika Virus Infects Human Cortical Neural Profenitors and Attenuates Their Growth.
Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM, Christian KM, Didier RA, Jin P, Song H Ming G
PMID: 26952870

5/20/2016​ Michael Oliphant ​​​​​​Sci Rep. 2016 Jan 27;6:19916.  doi: 10.1038/srep19916.
Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration.
Zong S, Li C, Luo C, Zhao X, Liu C, Wang K, Jia W, Bai M, Yin M, Bao S, Guo J, Kang J, Duan T, Zhou Q.
PMID: 26814137​

​6/24/2016 Taylor Soderborg ​​​​​Behav Brain Res. 2016 May 20;311:219-227. doi:10.1016/j.bbr.2016.05.040.
Microbial modulation of behavior and stress responses in sebrafish larvae.
Davis DJ, Bryda EC, Gillespie CH, Ericsson AC.
PMID: 27217102

​​​Date​ ​Presenter​ Paper Citation​
10/24/2014 ​Becca Green​ ​In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. E.J. Radford et al., Science 345, 1255903 (2014). DOI: 10.1126/science. 1255903

PMID: 25011554​
​11/21/2014 ​Linnea Schmidt ​Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS ONE 8(12): e85075. SOI: 10.1371/journal.pone.0085075

PMID: 24376867
​12/12/2014 ​Adrianne Stefanski ​The midblastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis. Mol Cell Biol 2011, 31:3857-3870. DOI: 10.1128/MCG.05411-11. EPUB 2011 Jul 26.

PMID: 21791613
​01/09/2015 ​Taylor Soderborg ​The gut microbiota influences blood-brain barrier permeability in mice. Braniste, V., Al-Asmakh, M., Kowal, C., et al. (2014) Science Translational Medicine 6(263): 263ra158. SOI: 10.1126/scitranslmed. 300975

PMID: 25411471​
​01/23/2015 ​Michael Oliphant  ​ERα​-regulated Lipocalin 2 Expression in Adipose Tissue Links Obesity with Breast Cancer Progression. J. Biol. Chem. jbc. M114.606459. First Published on December 2, 2014, DOI: 10.1074/jbc.M114-606459

PMID: 25468909
​02/13/2015 ​Ally Booth ​Exposure of Femal Macaques to Wester-Style Diet with or without Chronic Testosterone in vivo Alters Secondary Follicle Function during Encapsulated 3-Dimensional Culture. Xuj, McGee WK, Bishop CV, Park BS, Cameron JL, Zelinski MB, Stouffer RL. Endocrinology (2014) [Epub ahead of print]

PMID: 25545382
​03/13/2015 ​Sydney Coats

​Effect of pre-and postnatal growth and post-weaning activity on glucose metabolism in the offspring. J Endocrinol. 2015 Feb;224(2):171-82. doi: 10.1530/JOE-14-0600. Epub 2014 Nov 21. 

PMID: 25416820

​Rebe​cca Foright
Hypothalamic POMC neurons promote cannabinoid-induced feeding. Marco Koch1,2, Luis Varela1, Jae Geun Kim1{, Jung Dae Kim1,3, Francisco Herna´ndez-Nun˜o1, Stephanie E. Simonds4, Carlos M. Castorena5, Claudia R. Vianna5, Joel K. Elmquist5, Yury M. Morozov6, Pasko Rakic6,7, Ingo Bechmann2, Michael A. Cowley4, Klara Szigeti-Buck1, Marcelo O. Dietrich1,6, Xiao-Bing Gao1, Sabrina Diano1,3,6 & Tamas L. Horvath1,3,6,7

​04/24/2015 ​Andrew Libby

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents. Luck H, et al. Cell Metabolism. 2015 Apr 7; 21(4): 527-42.

PMID: 25863246

David Presby

​AMPK Regulates Energy Expenditure by Modulating NAD+ Metabolism and SIRT1 Activity. Cantó C, et al. Nature 2009 Apr 23; 458(7241): 1056-60.

PMID: 19262508​
​05/8/2015​ ​Thomas Jansson, MD PhD, Chief, Division of Basic Reproductive Sciences
​How to Write an Irresistible Specific Aims Page.