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University of Colorado Center for NeuroScience Denver

Center for NeuroSurgery
 

Rodent In Vivo Neurophysiology Core


The EEG core facility provides continuous rodent behavioral (video) and neurophysiological/EEG monitoring services (including cerebral electrical patterns during waking and sleep) to researchers. This type of monitoring will permit investigators to more thoroughly phenotype the rodents they use in their research and specifically address issues of whether they have abnormalities of neurophysiological functioning such as interictal epileptiform discharges, sleep disturbances and seizures. This can be important for the characterization of translational models of nervous system disorders, including stroke, epilepsy, head trauma, neurodegenerative, psychiatric, genetic and developmental disorders. The EEG Core, located in the RC1 Laboratory Animal Facility, has dedicated procedure room for stereotaxy and space for video-EEG monitoring. The core has the capability to video-EEG monitor 32 rats and 20 mice simultaneously using Stellate (Natus Medical Incorporated, San Carlos, CA) Pinnacle (Pinnacle Technology Inc., Lawrence, KS) and Triangle (Triangle BioSystems International, Durham, NC) equipment. The core is equipped with inhalation anesthesia systems, and digital, motorized, computer controlled stereotactic apparatus for electrode placement and cerebral injections in rat and mouse brain. The EEG core users will have free access to Review Stations located on the 3rd floor of the School of Pharmacy to review and analyze data. The review computers are loaded with Stellate, Pinnacle and Lab Chart software.
 
The core has been serving the University of Colorado researchers since 2009 and on average records over 60,000 video-EEG hours in a year. In addition to video-EEG monitoring facility, the core will also provide on-site training (stereotaxic surgery), and consultation regarding experimental design. 
 

How to Use the Core
To schedule an appointment for video-EEG recording, please send an email to Robert Valdez. You must have an approved animal protocol for surgical implantation of electrodes and for video-EEG monitoring. Contact Yogendra Raol to schedule a consultation, and to obtain standard operating procedures (SOP) for electrode implantation and video-EEG monitoring. 
Contact:      Yogendra Raol, PhD; Robert Valdez
                        Tel: 303-724-4257; 303-724-4249
                        Email: Yogendra.Raol@ucdenver.edu ; Robert.Valdez@ucdenver.edu
Location:     University of Colorado Denver- Anschutz Medical Campus
                        Research Complex I, Laboratory Animal Facility
                        12700 E. 19th avenue, Aurora, CO 80045