May 8-11, 2019 Christiania At Vail
To convene researchers active in alphaherpesvirus latency to discuss current advances in a relaxed venue.
Neurotropic alphaherpesviruses include herpes simplex virus types 1 and 2 and varicella zoster virus and are characterized by their ability to establish latency in cranial nerve ganglia (HSV-1 and VZV), dorsal root ganglia (VZV), sacral ganglia (VZV and HSV-2) and autonomic ganglia (VZV). While the viruses contain 70 (VZV) to 86 (HSV-1) open reading frames, most of which are expressed during productive infection, during latency, large parts of the virus genome are silenced, and virus replication is blocked. Disease associated with reactivation of latent virus is often more serious than primary infection. Understanding the molecular mechanism of latency (establishment, maintenance and reactivation) will set the groundwork required to develop effective therapies. To this end, the Colorado Alphaherpesvirus Latency Society has been formed with the explicit goal of providing a forum to present, discuss and propose current and future work to understand the neurobiology of these unique human pathogens.
For further information, contact Randall Cohrs at Randall.Cohrs@ucdenver.edu