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Faculty D-J


Evgenia Dobrinskikh, PhD

Research Instructor

Research Profile


 

Charles Edelstein, MD, PhD

Professor

Through his Department of Veterans Affairs Merit Award, Dr. Edelstein investigates the pathophysiology of cisplatin-induced acute kidney injury (AKI) in a clinically relevant model of mice with cancer.  Through his industry and Department of Defense-funded grants, Dr. Edelstein investigates mammalian target of rapamycin signaling and autophagy in rodent models of polycystic kidney disease (PKD). He is the principal investigator on numerous clinical studies in patients with PKD and is interested in biomarkers of AKI, having edited a book on biomarkers in kidney diseases. Dr. Edelstein does inpatient attending at both the VA and University Hospitals and has a weekly clinic at the University Hospital that specializes in PKD.

Clinical Profile

Research Profile



 

 


Sarah Faubel, MD

Professor

Mentoring Program Director

Dr. Faubel is primarily interested in acute kidney injury (AKI) and, specifically, the improvement of care for patients with AKI. She was chair of the American Society of Nephrology AKI Advisory Group and is funded by both the National Institutes of Health and the VA to study the distant organ effects of AKI in rodent models, the results of which have been translated to patients. Dr. Faubel’s primary research interests are in systemic inflammation, lung injury, and immune dysfunction after AKI.  She hypothesizes that that dysregulated inflammation after AKI is a key force behind deleterious systemic effects, organ injury, susceptibility to sepsis, and increased mortality associated with AKI. Her overall goal, through this research, is to identify treatable complications of AKI in order to reduce the mortality rate in patients.

Clinical Profile

Research Profile

  




Elizabeth Flanigan, NP

Instructor

Ms. Flanigan’s nursing career spans more than twenty years, and she is highly experienced at working in both inpatient and outpatient clinics, as well as outpatient dialysis areas.  Her background consists of critical care and nephrology, and Ms. Flanigan enjoys teaching nurse practitioner and physician assistant students in the clinical setting.

Clinical Profile

Research Profile











 

 

Seth Furgeson, MD

Assistant Professor

Dr. Furgeson’s primary research interest is in signaling pathways that regulate cardiovascular remodeling and renal fibrosis. Clinically, Dr. Furgeson cares for chronic hemodialysis patients at Denver Health Medical Center (Denver Health) and peritoneal dialysis patients at both the University of Colorado Hospital and Denver Health. He is also an inpatient attending on the Internal Medicine and Nephrology Consult Services at Denver Health.

Clinical Profile

Research Profile






Gabriela Garcia, MD

Associate Research Professor

Dr. Garcia’s primary research interest is in identifying mediators that drive inflammation and endogenous factors that regulate counter anti-inflammatory processes in the kidney. Inflammation has an important role in the development and progression of most chronic kidney diseases, yet understanding and preventing inflammation and progressive fibrosis of the kidney remain unsolved challenges that Dr. Garcia hopes to influence through her work.

Research Profile




Leann Gilmour, NP

Instructor

Ms. Gilmour has worked in healthcare since 2005 and has been with the Renal Division since August 2015. In 2006, she obtained her Associate of Nursing in Dyersburg, Tennessee, then went on to obtain her Bachelor of Science equivalency and a Master of Science in Nursing from Vanderbilt University with a specialty in acute care. She has previous experience working in an intensive care unit and in cardiovascular services, and also served as a transplant coordinator. Ms. Gilmour is passionate about caring for patients in all stages of the transplant process, from those who have just received transplants to those who still require them.

Clinical Profile

Research Profile







Berenice Gitomer, PhD

Research Professor

For the past 27 years, Dr. Gitomer has conducted research on genetic diseases of the kidney and, since joining the Renal Division in 2003, has focused on translational studies related to autosomal dominant polycystic kidney disease (ADPKD). She is primarily interested in those factors, genetic and environmental, that affect the severity of ADPKD. Notably, the National Institutes of Health has funded several of Dr. Gitomer’s studies examining the roles of angiogenesis, fibroblast growth factor 23, endothelial dysfunction and modifier genes in human ADPKD. These studies, conducted in collaboration with her clinical colleagues, have resulted in several breakthroughs, including the first description of a bone defect in patients with ADPKD.

Research Profile







Katharina Hopp, PhD

Research Instructor

Dr. Hopp attempts to understand, through her research, the underlying pathomechanisms driving autosomal dominant polycystic disease progression. Specifically, she investigates those genetics driving phenotypic heterogeneity amongst patients by studying different murine models and by sequencing human samples. She also studies the renal cystic microenvironment to better understand the role of immune cells in ADPKD pathogenesis. Through this research, Dr. Hopp aims to identify novel pathways that can be translated into either pre-clinical or clinical trials for further study. 

Research Profile










Diana Jalal, MD  

Associate Professor

Clinical Director of Renal at UCH

Dr. Jalal’s primary areas of interest are chronic kidney disease (CKD) and the means for improving all aspects of care related to CKD-affected patients. She received funding from the National Institutes of Health to study whether lowering serum uric acid levels in patients with CKD improves vascular function and inflammation. She is also the principal investigator on several multi-center clinical trials for patients with CKD where she investigates, in part, CKD progression and new therapy agents, such as the phosphate binder ferric citrate. In addition, Dr. Jalal serves on the editorial board for the journal “Advances in Chronic Kidney Disease.”

Clinical Profile

Research Profile




Alkesh Jani, MD

Professor

VA Renal Section Chief

Dr. Jani attends at both the University of Colorado and VA Hospitals, and is funded by the VA to study the prevention of ischemic delayed graft function in a mouse kidney transplant model.  Dr. Jani is interested in understanding, through research, the ways in which hibernating mammals are protected from prolonged cold ischemia/warm reperfusion.


Clinical Profile

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Richard Johnson, MD

Tomas Berl Professor of Medicine

Division Head, Division of Renal Diseases and Hypertension

Dr. Johnson has served as head of the Division since 2008. He is a highly cited scientist who authored The Sugar Fix in 2008 and The Fat Switch in 2012. He has lectured in over 40 countries and has been funded by the National Institutes of Health to conduct research. Dr. Johnson’s primary research interests are the mechanisms causing kidney disease, as well as the mechanisms causing obesity, diabetes, and heart disease. He is especially interested in the potential roles of sugar (especially fructose) and its byproduct, uric acid, in driving metabolic and kidney disorders. Most recently, Dr. Johnson’s work has shifted to the ways in which animals survive climate change, and the potential roles of heat stress and dehydration in causing chronic kidney disease. He also has an active clinical practice and enjoys patient care.

Clinical Profile

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Anna Jovanovich, MD

Assistant Professor

Dr. Jovanovich is a physician investigator in the fields of chronic kidney disease and phosphorus metabolism, and she regularly sees patients at the Denver VA Medical Center. Dr. Jovanovich also develops curriculum in palliative and supportive care within the field of nephrology. She teaches nephrology fellows, internal medicine residents, and medical students in the clinical setting. 

Research Profile