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Kevin Deane, MD, PhD

Associate Professor of Medicine


We now know that a variety of autoimmune diseases have a ‘preclinical’ period of development where blood or other tests can show abnormalities in the immune system sometimes years prior to an individual actually feeling sick from the disease. Dr. Deane’s research is focused primarily on the preclinical period of the disease rheumatoid arthritis (RA), and he is currently involved as a co-investigator in a multi-centered study investigating how genetics and environmental factors influence the early development of RA. He also has special interests in the mechanistic role of the lung and other mucosal sites in the development of RA.

 

Dr. Deane is also the Principal Investigator on an NIH-sponsored clinical trial for the prevention of RA that is entitled ‘Strategy for the Prevention of RA, or ‘StopRA’. For this trial, individuals (including relatives of patients with RA) will be recruited who have blood markers suggesting they are at high-risk of developing RA themselves within several years. These individuals will then be given a drug to see if we can stop the development of RA in its preclinical phase before even the first signs of arthritis develop. Dr. Deane and his team have great hope that this trial will be a large part of a major change in how we approach RA and other autoimmune diseases where instead of just treating these diseases once people become sick, we will instead try and prevent them during an asymptomatic phase – much like cardiac disease is managed today where risk factors for disease such as high cholesterol, high blood pressure and diabetes are controlled in order to prevent future heart attacks. Enrollment for this trial is expected to begin during the fall of 2015. If you would like to learn more, please contact StopRA@UCDenver.edu or call 303-724-8330.

 

Dr. Deane’s clinical activities include the evaluation and treatment of a wide variety of rheumatic diseases, with a special focus on rheumatoid arthritis, and management of the non-thrombotic manifestations of the anti-phospholipid antibody syndrome. If you’d like to see him in clinic, please call 720-848-7700 or visit our practice website for more information.

 

Besides his work in rheumatic research and clinical care, Dr. Deane’s teaching activities include education of medical students, rheumatology fellows, and residents in internal medicine, orthopedics and physical medicine and rehabilitation in the evaluation and treatment of rheumatic diseases. Additionally, he teaches medical students regarding the pathophysiology of rheumatic diseases as well as courses on basic biostatistics in medical research, and graduate students in grant writing through the University of Colorado’s Graduate School.​


1987 – 1992       B.A. History University of California, Davis and Newbold College, Bracknell, Great ​                             Britain

1993 – 1997       M.D., Loma Linda University School of Medicine, Loma Linda, California

1997 – 2000       Intern and Resident in Internal Medicine, UCSOM

2001 – 2004       Rheumatology Fellowship, University of Colorado, SOM

2002 – 2011       Ph.D. Clinical Science University of Colorado, SOM. 

Thesis title:  Autoantibodies and inflammatory markers in the prediction of the time of future onset of symptomatic rheumatoid arthritis.

2000 – 2001      Chief Medical Resident, Department of Medicine, University of Colorado, SOM

 

2004 – 2005      Instructor, Division of Rheumatology, Department of Medicine, University of Colorado, SOM

 

2006 – 2012      Assistant Professor of Medicine, Division of Rheumatology, Department of Medicine, University of Colorado, SOM

 

2012 – present   Associate Professor of Medicine, Division of Rheumatology, Department of Medicine, University of Colorado, SOM

 

2014 – present   Staff physician, Veteran’s Affairs Hospital, Denver, Colorado​​

PROFESSIONAL ORGANIZATIONS/MEMBERSHIPS
2001 - present American College of Rheumatology
2006 - present       American Federation for Medical Research (ID 183537)

MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES
2004 - present Division of Rheumatology website design and maintenance.
2005 - 2012         American College of Rheumatology Early Career Investigator Subcommittee;                                   Chair from 2009 to 2012.
2006 - 2010         Rheumatology clinic new-patient referral screening.
2008 - present Director, 9Health Fair Rheumatoid Arthritis Screening Program
2009 - present Abstract review and session moderator, Oral Abstract Presentations, American                                 College of Rheumatology Annual Meetings.
2009 - present Moderator, Rheumatology/Immunology Research Presentations, American                                       Federation for Medical Research Carmel Meeting.
2010 - present Safety officer, “Is Uric Acid a Mediator of Endothelial Dysfunction in Patients                                     with Chronic Kidney Disease”, PI Diana Jalal (NIH K Award).
2011        Site host, International Consortium of Preclinical Rheumatoid Arthritis                                            Researchers.  Chicago, IL, November 5th 2011.
2011 - 2012         American College of Rheumatology Research Agenda Task Force.
2011 - present Councilor, Western Region American Federation of Medical Re-search  
2013         Co-Chair, American College of Rheumatology Clinical Research Conference                                       “Preclinical Rheumatic Disease”
2015-          Lead Reviewer, Immunology/Rheumatology Abstracts Western Region                                            American Federation for Medical Research
1997               Alpha Omega Alpha Membership

1997               Daniel D. Comstock Award for Excellence in Internal Medicine (Loma Linda University School of Medicine)

1998, 2001    Golden Apple Medical Student Teaching Award UCSOM (as resident and fellow)

2012               Medical Student Teaching Award, Physical Examination, Foundations of Doctoring, UCSOM​

​Selected Publications:

1.         Mackey RH, Kuller LH, Deane KD, Walitt BT, Chang YF, Holers VM, Robinson WH, Tracy RP, Hlatky MA, Eaton C, Liu S, Freiberg MS, Birru Talabi M, Schelbert EB, Moreland LW. Rheumatoid arthritis, anti-CCP positivity, and cardiovascular disease risk in the Women's Health Initiative. Arthritis & rheumatology. 2015. doi: 10.1002/art.39198. PubMed PMID: 25988241.

2.         Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM. Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. The Journal of rheumatology. 2015;42(4):572-9. doi: 10.3899/jrheum.140767. PubMed PMID: 25593232; PubMed Central PMCID: PMC4383711.

3.         Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR, Jr., Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, Sayre EC. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clinical rheumatology. 2015;34(3):465-70. doi: 10.1007/s10067-014-2796-7. PubMed PMID: 25339123.

4.         Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Liu S, Parks CG, Wright NC, Moreland LW. Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis. Arthritis & rheumatology. 2014;66(3):497-507. doi: 10.1002/art.38268. PubMed PMID: 24574208.

5.         Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Moreland LW. Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. American journal of epidemiology. 2014;179(7):917-26. doi: 10.1093/aje/kwu003. PubMed PMID: 24569640; PubMed Central PMCID: PMC3969537.

6.         Demoruelle MK, Deane KD, Holers VM. When and where does inflammation begin in rheumatoid arthritis? Current opinion in rheumatology. 2014;26(1):64-71. doi: 10.1097/BOR.0000000000000017. PubMed PMID: 24247116; PubMed Central PMCID: PMC4033623.

7.         Deane KD, El-Gabalawy H. Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE. Nature reviews Rheumatology. 2014;10(4):212-28. doi: 10.1038/nrrheum.2014.6. PubMed PMID: 24514912; PubMed Central PMCID: PMC4090326.

8.         Finckh A, Deane KD. Prevention of rheumatic diseases: strategies, caveats, and future directions. Rheumatic diseases clinics of North America. 2014;40(4):771-85. doi: 10.1016/j.rdc.2014.07.010. PubMed PMID: 25437291; PubMed Central PMCID: PMC4250827.

9.         Willis VC, Demoruelle MK, Derber LA, Chartier-Logan CJ, Parish MC, Pedraza IF, Weisman MH, Norris JM, Holers VM, Deane KD. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease. Arthritis and rheumatism. 2013;65(10):2545-54. doi: 10.1002/art.38066. PubMed PMID: 23817979; PubMed Central PMCID: PMC4066465.

10.       Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis and rheumatism. 2013;65(8):1995-2004. doi: 10.1002/art.38022. PubMed PMID: 23754702; PubMed Central PMCID: PMC3729718.

11.       Demoruelle MK, Parish MC, Derber LA, Kolfenbach JR, Hughes-Austin JM, Weisman MH, Gilliland W, Edison JD, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Norris JM, Holers VM, Deane KD. Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arthritis and rheumatism. 2013;65(9):2243-52. doi: 10.1002/art.38017. PubMed PMID: 23686569; PubMed Central PMCID: PMC3776020.

12.       Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Annals of the rheumatic diseases. 2013;72(12):2002-5. doi: 10.1136/annrheumdis-2012-202949. PubMed PMID: 23572338; PubMed Central PMCID: PMC3818364.

13.       Walitt B, Mackey R, Kuller L, Deane KD, Robinson W, Holers VM, Chang YF, Moreland L. Predictive value of autoantibody testing for validating self-reported diagnoses of rheumatoid arthritis in the Women's Health Initiative. American journal of epidemiology. 2013;177(9):887-93. doi: 10.1093/aje/kws310. PubMed PMID: 23492764; PubMed Central PMCID: PMC4023293.

14.       Hughes-Austin JM, Deane KD, Derber LA, Kolfenbach JR, Zerbe GO, Sokolove J, Lahey LJ, Weisman MH, Buckner JH, Mikuls TR, O'Dell JR, Keating RM, Gregersen PK, Robinson WH, Holers VM, Norris JM. Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). Annals of the rheumatic diseases. 2013;72(6):901-7. doi: 10.1136/annrheumdis-2012-201505. PubMed PMID: 22915618; PubMed Central PMCID: PMC3726193.

15.       Demoruelle MK, Kahr A, Verilhac K, Deane K, Fischer A, West S. Recent-onset systemic lupus erythematosus complicated by acute respiratory failure. Arthritis care & research. 2013;65(2):314-23. doi: 10.1002/acr.21857. PubMed PMID: 22972558.

16.       Moreau KL, Deane KD, Meditz AL, Kohrt WM. Tumor necrosis factor-alpha inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Atherosclerosis. 2013;230(2):390-6. doi: 10.1016/j.atherosclerosis.2013.07.057. PubMed PMID: 24075772; PubMed Central PMCID: PMC3815590.

17.       Deane KD. Can rheumatoid arthritis be prevented? Best practice & research Clinical rheumatology. 2013;27(4):467-85. doi: 10.1016/j.berh.2013.09.002. PubMed PMID: 24315049; PubMed Central PMCID: PMC3926812.

18.       Deane KD, Nicolls MR. Developing better biomarkers for connective tissue disease-associated interstitial lung disease: citrullinated hsp90 autoantibodies in rheumatoid arthritis. Arthritis and rheumatism. 2013;65(4):864-8. doi: 10.1002/art.37878. PubMed PMID: 23400799; PubMed Central PMCID: PMC4036626.

19.       Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, Sayles H, Weisman MH, Gregersen PK, Buckner JH, Keating RM, Derber LA, Robinson WH, Holers VM, Norris JM. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis and rheumatism. 2012;64(11):3522-30. doi: 10.1002/art.34595. PubMed PMID: 22736291; PubMed Central PMCID: PMC3467347.

20.       Sokolove J, Bromberg R, Deane KD, Lahey LJ, Derber LA, Chandra PE, Edison JD, Gilliland WR, Tibshirani RJ, Norris JM, Holers VM, Robinson WH. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PloS one. 2012;7(5):e35296. doi: 10.1371/journal.pone.0035296. PubMed PMID: 22662108; PubMed Central PMCID: PMC3360701.

21.       Demoruelle MK, Weisman MH, Simonian PL, Lynch DA, Sachs PB, Pedraza IF, Harrington AR, Kolfenbach JR, Striebich CC, Pham QN, Strickland CD, Petersen BD, Parish MC, Derber LA, Norris JM, Holers VM, Deane KD. Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis and rheumatism. 2012;64(6):1756-61. doi: 10.1002/art.34344. PubMed PMID: 22183986; PubMed Central PMCID: PMC3319006.

22.       Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. The Journal of clinical endocrinology and metabolism. 2012;97(12):4692-700. doi: 10.1210/jc.2012-2244. PubMed PMID: 22969140; PubMed Central PMCID: PMC3513538.

23.       Moreau KL, Meditz A, Deane KD, Kohrt WM. Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. American journal of physiology Heart and circulatory physiology. 2012;302(5):H1211-8. doi: 10.1152/ajpheart.01065.2011. PubMed PMID: 22245769; PubMed Central PMCID: PMC3311456.

24.       Karlson EW, Deane K. Environmental and gene-environment interactions and risk of rheumatoid arthritis. Rheumatic diseases clinics of North America. 2012;38(2):405-26. doi: 10.1016/j.rdc.2012.04.002. PubMed PMID: 22819092; PubMed Central PMCID: PMC3402910.

25.       Demoruelle MK, Deane KD. Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis. Current rheumatology reports. 2012;14(5):472-80. doi: 10.1007/s11926-012-0275-1. PubMed PMID: 22773387; PubMed Central PMCID: PMC3616381.

26.       Fischer A, Solomon JJ, du Bois RM, Deane KD, Olson AL, Fernandez-Perez ER, Huie TJ, Stevens AD, Gill MB, Rabinovitch AM, Lynch DA, Burns DA, Pineiro IS, Groshong SD, Duarte Achcar RD, Brown KK, Martin RJ, Swigris JJ. Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease. Respiratory medicine. 2012;106(7):1040-7. doi: 10.1016/j.rmed.2012.03.006. PubMed PMID: 22503074; PubMed Central PMCID: PMC3753791.

27.       Deane KD. Learning about the natural history of rheumatoid arthritis development through prospective study of subjects at high risk of rheumatoid arthritis-related autoimmunity. Arthritis and rheumatism. 2012;64(6):1708-12. doi: 10.1002/art.34445. PubMed PMID: 22354795; PubMed Central PMCID: PMC4527318.

28.       Deane KD, O'Donnell CI, Hueber W, Majka DS, Lazar AA, Derber LA, Gilliland WR, Edison JD, Norris JM, Robinson WH, Holers VM. The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis and rheumatism. 2010;62(11):3161-72. doi: 10.1002/art.27638. PubMed PMID: 20597112; PubMed Central PMCID: PMC2980824.

29.       Deane KD, Norris JM, Holers VM. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation. Rheumatic diseases clinics of North America. 2010;36(2):213-41. doi: 10.1016/j.rdc.2010.02.001. PubMed PMID: 20510231; PubMed Central PMCID: PMC2879710.

30.       Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O'Donnell CI, Derber LA, Weinblatt ME, Shadick NA, Bell DA, Cairns E, Solomon DH, Holers VM, Rudd PM, Lee DM. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis and rheumatism. 2010;62(8):2239-48. doi: 10.1002/art.27533. PubMed PMID: 20506563; PubMed Central PMCID: PMC4118465.

31.       Kolfenbach JR, Deane KD, Derber LA, O'Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis and rheumatism. 2010;62(9):2633-9. doi: 10.1002/art.27570. PubMed PMID: 20496417; PubMed Central PMCID: PMC2946499.

32.       Kolfenbach JR, Deane KD, Derber LA, O'Donnell C, Weisman MH, Buckner JH, Gersuk VH, Wei S, Mikuls TR, O'Dell J, Gregersen PK, Keating RM, Norris JM, Holers VM. A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis and rheumatism. 2009;61(12):1735-42. doi: 10.1002/art.24833. PubMed PMID: 19950324; PubMed Central PMCID: PMC2795101.

33.       Deane KD, Striebich CC, Goldstein BL, Derber LA, Parish MC, Feser ML, Hamburger EM, Brake S, Belz C, Goddard J, Norris JM, Karlson EW, Holers VM. Identification of undiagnosed inflammatory arthritis in a community health fair screen. Arthritis and rheumatism. 2009;61(12):1642-9. doi: 10.1002/art.24834. PubMed PMID: 19950306; PubMed Central PMCID: PMC2913880.

34.       Feser M, Derber LA, Deane KD, Lezotte DC, Weisman MH, Buckner JH, Mikuls T, O'Dell J, Gregersen PK, Holers VM, Norris JM. Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. The Journal of rheumatology. 2009;36(5):943-6. doi: 10.3899/jrheum.080764. PubMed PMID: 19286844; PubMed Central PMCID: PMC2745328.

35.       Gizinski AM, Mascolo M, Loucks JL, Kervitsky A, Meehan RT, Brown KK, Holers VM, Deane KD. Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA. Clinical rheumatology. 2009;28(5):611-3. doi: 10.1007/s10067-009-1128-9. PubMed PMID: 19252818; PubMed Central PMCID: PMC4084723.

36.       Majka DS, Deane KD, Parrish LA, Lazar AA, Baron AE, Walker CW, Rubertone MV, Gilliland WR, Norris JM, Holers VM. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis. Annals of the rheumatic diseases. 2008;67(6):801-7. doi: 10.1136/ard.2007.076679. PubMed PMID: 17974596; PubMed Central PMCID: PMC3761074.

37.       Ferucci ED, Majka DS, Parrish LA, Moroldo MB, Ryan M, Passo M, Thompson SD, Deane KD, Rewers M, Arend WP, Glass DN, Norris JM, Holers VM. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis and rheumatism. 2005;52(1):239-46. doi: 10.1002/art.20773. PubMed PMID: 15641089.

38.       Deane KD, West SG. Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review. Seminars in arthritis and rheumatism. 2005;35(3):154-65. doi: 10.1016/j.semarthrit.2005.05.006. PubMed PMID: 16325656.