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Colorado Pulmonary-Alcohol Research Consortium (CoPARC)

 

Consortium Research Biological Samples


Various types of biologic samples will be obtained from subjects enrolled in consortium investigations. Please see table below for complete details.

a. From subjects with alcohol use disorders and healthy controls. Enrolled individuals will have sampling conducted in a clinical translational research center (CTRC) or similarly controlled setting. Bronchoscopy with bronchoalveolar lavage (BAL) and brushings will be performed by the principal investigator or her co-investigators, all of whom are pulmonologists.

b. From burn subjects (patients). Enrolled patients will have data collection and sampling performed in the burn ICU setting, including validated alcohol questionnaires. Information regarding alcohol history is valid when collected by surrogate, and will be confirmed from patients that recover. Data collection, as well as biologic sampling will be performed by trained personnel. Bronchoscopy will be performed by the PI or her co-investigators, all of whom have extensive experience in research bronchoscopy.

Table. Description of subject type and planned consortium sample collection after screening and informed consent process.

  Single bronchoscopy protocol, uninjured volunteers Longitudinal bronchoscopy protocol (planned) Burn patient protocol
Subject type(s)

AUD Subjects &
Pair-matched controls

AUD subjects

Burn ICU patients, with and without AUDs

Demographic and alcohol data

Yes, from subject

Yes, from subject

Yes, from health care proxy (patient when possible)

Length of stay in CTRC/ICU

1 (controls) to 3 (AUDs) days

9 days

varies

Blood (plasma, serum, buffy coat)

On Day 1

Daily over 7 days

On Day 1

Bronchoscopic samples

BAL, brushings (microbiologic & cytologic) on Day 1

BAL, brushings (microbiologic & cytologic) on Days 1 & 7

BAL on Day 1

Exhaled breath condensate (EBC)

On Day 1

On Days 1 & 7

On Day 1, 3, and 5

Other

Oropharyngeal sampling on day 1
Clean catch Urine on Day 1

Clean catch Urine on Day 1 and 7

Clean catch urine on day 1