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Colorado Pulmonary-Alcohol Research Consortium (CoPARC)

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How can CoPARC Help You?

  • translational research support in the field of alcohol abuse/dependence
  • clinical research support in the field of alcohol abuse/dependence
  • biorepository of human subjects’ samples and data

Welcome to CoPARC

The Colorado Pulmonary-Alcohol Research Consortium (CoPARC) is focused on investigations in the pathogenesis and treatment of pulmonary diseases associated with alcohol use disorders (AUDs). Investigators have sought to identify alcohol-related defects in pulmonary host defense mediators in humans, including two pulmonary cell types critical to lung immunity: alveolar macrophages (AMs) and bronchoalveolar epithelial cells (BAECs). Through their prior and ongoing research efforts, CoPARC investigators believe that AUDs, with or without smoking, negatively impact the pulmonary immune response, rendering individuals more susceptible to bacterial pneumonia and the acute respiratory distress syndrome (ARDS), characterized by respiratory failure and poor outcomes in the AUD setting. Planned experiments will delineate roles for clinically available therapeutics to normalize pulmonary immune cell phenotype and activity, and will further define aberrant AUD-and smoking- associated immune mechanisms that may predispose to pneumonia, or impair pneumonia resolution. Mechanisms defined in the ambulatory population with AUDs will be examined in cohorts of critically ill patients, including patients with respiratory failure, both to determine their impact on clinical outcomes, and to identify patients who may benefit from targeted therapies.


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Colorado Pulmonary-Alcohol Research Consortium (CoPARC) Funding

This website and the research reported here is supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award number R24AA019661.

Additional support is provided by the Colorado Clinical and Translational Sciences Institute on the University of Colorado Anschutz Medical Campus, funded by NIH/NCATS award number UL1TR001082.

The Thoracic Foundation #AWD161639

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