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Colorado Pulmonary-Alcohol Research Consortium (CoPARC)

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How can CoPARC Help You?

  • Translational research support in the field of alcohol abuse/dependence
  • Clinical research support in the field of alcohol abuse/dependence
  • Biorepository of human subjects’ samples and data.

Welcome to CoPARC

The Colorado Pulmonary-Alcohol Research Collaborative (CoPARC) focused on investigations in the pa​thogenesis and treatment of pulmonary diseases associated with alcohol use disorders (AUDs). Investigators have sought to identify alcohol-related defects in pulmonary host defense. CoPARC investigators believe that AUDs, with or without smoking, negatively impact the pulmonary immune response, rendering individuals more susceptible to bacterial pneumonia and the acute respiratory distress syndrome. Planned experiments will delineate roles for clinically available therapeutics to normalize pulmonary immune function, and will further define aberrant AUD-and smoking- associated immune mechanisms that may predispose to pneumonia, or impair its resolution. Mechanisms defined will be further examined in cohorts of critically ill patients to determine their impact on clinical outcomes and to tailor therapy.

The CoPARC infrastructure at the University of Colorado has supported enrollment of subjects with AUDs and matched controls, and critically ill patients who have respiratory failure, some who have sustained burn injuries. Since 2011, an interactive environment has been developed between institutions with a history of NIAAA-funded translational research in pulmonary diseases, fostering growth of novel investigations, and providing opportunities for career development.

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Colorado Pulmonary-Alcohol Research Consortium (CoPARC) Funding

This website and the research reported here is supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award number R24AA019661.

Additional support is provided by the Colorado Clinical and Translational Sciences Institute on the University of Colorado Anschutz Medical Campus, funded by NIH/NCATS award number UL1TR001082.

The Thoracic Foundation #AWD161639

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