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Colorado Pulmonary-Alcohol Research Consortium (CoPARC)

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How can CoPARC Help You?

  • translational research support in the field of alcohol abuse/dependence
  • clinical research support in the field of alcohol abuse/dependence
  • biorepository of human subjects’ samples and data

Welcome to CoPARC

Acute respiratory distress syndrome (ARDS) is a common and devastating pulmonary disorder affecting about 190,000 people in the U.S. annually. Notably, people with alcohol use disorders (AUDs) are at increased risk for ARDS development, and for poorer outcomes including mortality and prolonged hospitalization. Specific mechanisms underlying the association between AUDs and ARDS remain ill-defined; however, pulmonary oxidative stress related to alcohol metabolism has been previously implicated in both ARDS susceptibility and outcomes. Additionally, a role for imbalance in the hypothalamic-pituitary-adrenal (HPA) axis can also be influenced by alcohol consumption and may play a further role in outcomes among the critically ill with AUDs who have respiratory failure. Our biorepository aims to characterize the influence of chronic alcohol consumption on oxidative stress and the HPA axis among critically ill patients with respiratory failure in the intensive care unit. We wish to understand the relationship of AUDs on outcomes in this population via its impact on these modifiable factors in human subjects, and will explore specific outcome variables in bronchoalveolar lavage and systemic clinical samples.

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Colorado Pulmonary-Alcohol Research Consortium (CoPARC) Funding

This website and the research reported here is supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award number R24AA019661.

Additional support is provided by the Colorado Clinical and Translational Sciences Institute on the University of Colorado Anschutz Medical Campus, funded under the National Center for Advancing Translational Sciences award number UL1TR001082.

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CoPARC Leader

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