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Robert J. Mason, M.D.

Professor of Medicine



  Robert J. Mason, M.D.
  Professor of Medicine


  University of Colorado Denver

  Pulmonary Sciences & Critical Care Medicine

  Phone: 303-724-0000 


Education & Training
Trinity College, Hartford, CT
1962 B.S. 

Western Reserve Medical School, Cleveland, OH
1966 M.D. Medicine



1966 - 1968
Harvard Medical Unit, Boston City Hospital, Internship & Medical Residency.

1968 - 1971
NIH, NHLBI, Clinical Associate (Dr. Martha Vaughan), Chief Resident 1970-1971.

1971 - 1974
Pulmonary Fellowship (Dr. John Clements, Dr. John Murray), University of California, San Francisco and Cardiovascular Research Institute.

1974 - 1980
Assistant Professor of Medicine, University of California, San Francisco.

1980 - 1981
Associate Professor of Medicine, University of California, San Francisco.

1983 - 1985
Co-Head, Pulmonary Division, University of Colorado, Denver, Colorado.

1985 - 1996
Chairman, Department of Medicine, National Jewish Center for Immunology & Respiratory Medicine, Denver, Colorado

1981 - present
Senior Faculty Member, National Jewish Hospital/National Asthma Center; Professor of Medicine, University of Colorado, Denver, Colorado

Associate Vice President for Academic Affairs, National Jewish Medical and Research Center, Denver, Colorado


Alpha Omega Alpha

Established Investigator, American Heart Association

Cecile Lehman Research Award, American College of Chest Physicians

MERIT Award, NHLBI, NIH 2000
Scientific Achievement Award, American Thoracic Society
American Society for Clinical Investigation
Association of American Physicians

Chair, FASEB Surfactant Conference

SELECTED PUBLICATIONS (From a list of more than 157 peer-reviewed papers)

Xu, X., McCormick-Shannon, K., Voelker, D.R. and Mason, R.J. KGF increases SP-A and SP-D mR

NA levels and secretion in cultured rat alveolar type II cells. Am. J. Cell Resp. Biol., 18:168-178, 1998.
Mason, R.J. Greene, K. and Voelker, D.R. Surfactant protein A and surfactant protein D in health and disease. Am. J. Physiol., 275:L1-L13, 1998.

Mason, R.J. and Voelker, D.R. Regulatory mechanisms of surfactant secretion. Biochim. Biophys. Acta, 1408: 226-240, 1998.

Mason, R.J., Nielsen, L.D., Kuroki, Y., Matsuura, E., Freed, J.H., and Shannon, J.M. A 50 kDa Variant Form of Human Surfactant Protein D. European Resp. J., 12:1147-1155, 1998.

Allen, M.J., Harbeck, R., Smith, B., Voelker, D.R., and Mason, R.J. Binding of Rat and Human Aspergillus fumigatus Condidia. Infect. Immun., 67:4563-4569, 1999.

Fehrenbach, H., Kasper, M., Tschernig, T., Pan, T., Schuh, D., Shannon, J.M., Muller, M. and Mason, R.J. Keratinocyte growth factor-induced hyperplasia of rat alveolar type II cells in vivo is resolved by differentiation into type I cells and by apoptosis. European Resp. J., 14:534-544, 1999.

Mason, R.J., Kalina, M., Nielson, L.D., Malkinson, A.M., and Shannon, J.M. Surfactant protein C expression in urethane-induced murine pulmonary tumors. Am. J. Path. 156:1-8, 2000.

Yano, T., R. J. Mason, T. Pan, R. R. Deterding, L. D. Nielsen, and J. M. Shannon. KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in the adult rat lung. Am J Physiol Lung Cell Mol Physiol 279:L1146-L1158. 2000.

Morikawa, O., T. A. Walker, L. D. Nielsen, T. Pan, J. L. Cook, and R. J. Mason. Effect of adenovector-mediated gene transfer of keratinocyte growth factor on the proliferation of alveolar type II cells in vitro and in vivo. Am J. Respir Cell Mol Biol 23:626-635, 2000.

Fehrenbach, H., M.Kasper, R.Koslowski, T.Pan, D.Schuh, M.Müller, R.J.Mason. Alveolar epithelial type II cell apoptosis in vivo during resolution of keratinocyte growth factor-induced hyperplasia in the rat. Histochem. Cell Biol. 114:49-61, 2000.

Fujita, M., Shannon, J.M., Irvin, C.G., Fagan, K.A., Cool, C., Augustin, A., and Mason, R.J. Overexpression of TNF-alpha in the lungs produces pulmonary hypertension and a physiologic phenotype consistent with emphysema. Am. J. Physiol. 280:L39-49, 2001.

Allen, M. J., D. R. Voelker, and R. J. Mason. Interactions of Surfactant Proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus. Infect Immun 69(4):2037-2044, 2001.

Shannon, J. M., T. Pan, L. D. Nielson, K. McCormick-Shannon, K. E. Edeen, V. D. Koenigsknecht, and R. J. Mason. Lung fibroblasts support improved differentiation of rat alveolar type II cells in primary culture. Am. J Respir. Cell Mol Biol., 24: 235-244, 2001.

Allen, M.J., Laederach, A., Reilly, P.J., Mason, R.J. Polysaccharide recognition by surfactant protein D: novel interactions of a C-type lectin with nonterminal glucosyl residues. Biochemistry, 40; 7789-98, 2001.

Greene, K. E., King, T. E., Kuroki, Y., Bucher-Bartleson, B., Hunninghake, G.W., Newman, L.S., Nagae, H. and Mason, R.J. Serum surfactant proteins A and D as biomarkers in idiopathic pulmonary fibrosis. Eur. Resp. Journal, Mar; 19(3):439-46, 2002

Pan, T., Robert J. Mason, R.J., Westcott, J.Y., and Shannon, J.M. Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro. American Journal of Respiratory Critical Care Medicine Cell Mol. Biol., 25: 353-61, 2001.

Nishina, K., Mikawa, K., Morikawa, O., Obara, H., and Mason, R.J. The effects of intravenous anesthetics and lidocaine on proliferation of cultured type II pneumocytes and lung fibroblasts. Anesth Analg, 94(2):385-388, 2002.

Mason, R.J., Lewis, M.C., Edeen, K.E., McCormick-Shannon, K., Nielsen, L.D., and Shannon, J.M. Maintenance of surfactant protein A and D secretion by rat alveolar type II cells in vitro. Am J Physiol Lung Cell Mol Physiol, 282(2)L249-258, 2002.

Pan, T., Nielsen, L.D., Allen, M.J., Shannon, K.M., Shannon, J.M., Selman, M., and Mason, R.J. Serum SP-D is a marker of lung injury in rats. Am. J. Physiol, 282 (4):L824-32, 2002.

Mason R.J. Hepatocyte growth factor: the key to alveolar septation? Am J Respir Cell Mol Biol;26(5):517-20, 2002.

Mason RJ, Pan T, Edeen KE, Nielsen LD, Zhang F, Longphre M, Eckart M, and Neben S. Keratinocyte growth factor and the transcription factors C/EBP a_____and delta and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. J. Clinical Investigation, 112:244-255, 2003.

Zhang F, Pao W, Umphress SM, Jakowlew SB, Meyer AM, Dwyer-Nield LD, Nielsen L, Takeda K, Gelfand EW, Fisher JH, Lening Zhang*, Malkinson AM, and Mason RJ. Serum levels of Surfactant Protein D are increased in mice with lung tumors. J. Cancer, in press.

Zhang F, Pan, T, Nielsen LD, Mason RJ. Lipogenesis in fetal rat lung: Importance of C/EBPa, SREBP-1c, and stearoyl CoA desaturase. Am. J. Respir Cell Mol Biol, in press.
Books and Reviews:

Mason, R.J., and Shannon, J.M. Alveolar type II cells. In: The Lung: Scientific Foundations, 2nd edition (Crystal, R.G., West, J.B., et al., eds), Raven Press, Ltd., New York, 1997, pp. 543-555.

Mason, R.J. and Lewis, J. Pulmonary surfactant. In: Textbook in Respiratory Medicine, 3rd edition, (Murray, J., Nadel, J., Mason, R.J., and Boushey, H., eds. Saunders Press, Philadelphia 2000