- Ph.D., Biophysics and Genetics
University of Colorado Health Sciences Center, 2006
Mentor: Steven M Anderson, PhD
Dissertation: Analysis of Potential Substrates for the
Pro-survival Kinase Akt
- B.A. cum laude, Molecular, Cellular, and Developmental Biology University of Colorado at Boulder, 1999
Dr. Lyons laboratory focuses on mechanisms of lymphatic mediated metastasis of breast cancer. Specifically, utilizing mouse models to investigate developmentally regulated programs of inflammation and lymphangiogenesis that are utilized in the adult mammary gland and may be hijacked by breast tumor cells. The results of these translational studies have the potential to instruct therapy aimed at prevention of breast cancer metastasis.
- NIH/NCI Research Grant (R01)
R01 CA211696-01A1 2017-2021
“Deciphering COX-2/SEMA7A dependent mechanisms of breast tumor progression"
(Traci R Lyons, PI)
- American Cancer Society
“Investigating the role(s) of SEMA7A in breast tumor progression”
(Traci R Lyons, PI)
- Cancer League of Colorado
“Evaluating the role of pro-lymphangiogenic factor SEMA7A in dampening anti-tumor immunity”
(Traci R Lyons and Beth Tamburini, Co-PIs)
- Golfer’s Against Cancer 2016-2017
“Deciphering the tumor extrinsic role of SEMA7A in breast cancer progression”
(Traci R Lyons and Kirk Hansen, Co-PIs)
- CancerCure Pilot Award 2015-2016(NCE)
“Addressing the role of lymphangiogenesis and obesity in breast cancer metastasis”
(Traci R Lyons, Paul MacLean, Erin Giles, Elizabeth Wellberg, Co-PIs)
1. Abitha Jacob,
Erik Linklater, Sarah Black, Paul Jedlicka, Traci R Lyons, and Rytis
Prekeris. “The role of miR-204 in regulating Rab40b/Tks5 protein complex
during MMP targeting and breast cancer metastasis.” Journal of Cell Science,
2016: doi: 10.1242/jcs.193904.
2. Virginia Borges,
Alan Elder, Traci R Lyons. “Deciphering pro-lymphangiogenic programs
during mammary involution and postpartum breast cancer.” Frontiers in
Oncology, 02 November 2016 | http://dx.doi.org/10.3389/fonc.2016.00227
3. Sarah Black,
Andrew Nelson, Natalia Gurule, Bernard Futscher, Traci R Lyons.
“Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression.”
Oncogene, (2016) 35, 5170–5178.
4. John Morton,
Gregory Bird, Stephen Keysar, David Astling, Traci R Lyons, Ryan
Anderson, Magdalena Glogowska, Patricia Estes, Justin Eagles, Phuong Le,
Gregory Gan, Brett McGettigan, Pamela Fernandez, Nuria Padilla-Just, Marileila
Garcia, John Song, Daniel Bowles, Pepper Schedin, Aik Choon Tan, Dennis R Roop,
Xiao-Jing Wang, and Yosef Refaeli, Antonio Jimeno. “XactMice: humanizing
mouse bone marrow enables microenvironment reconstitution in a patient-derived
xenograft model of head and neck cancer" Oncogene. 2016 Jan
21;35(3):290-300. doi: 10.1038/onc.2015.94.
5. Traci R
Lyons, Virginia Borges, Courtney
Betts, Qiuchen Guo, Puja Kapoor, Holly Martinson, Sonali Jindal, Pepper
Schedin. “Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal
metastasis of postpartum breast cancer.” Journal of Clinical Investigation,
2014 Sep 2;124(9):3901-12.
6. Jaime Fornetti,
Holly A. Martinson, Courtney B. Betts, Traci R. Lyons, Sonali Jindal,
Qiuchen Guo, Lisa M. Coussens, Virginia F. Borges, Pepper Schedin. “Mammary
Gland Involution as an Immunotherapeutic Target for Postpartum Breast Cancer.” Journal
of Mammary Gland Biology and Neoplasia, 2014 Vol: 19(2):213-228.
7. Ori Maller, Kirk
Hansen, Traci R Lyons, Irene Acerbi, Valerie M Weaver, Rytis Prekeris,
Aik Choon Tan, and Pepper Schedin. “Collagen architecture in
pregnancy-induced protection from breast cancer.” Journal of Cell Science.
2013 Sep 15;126(Pt 18):4108-10.
8. Holly Martinson, Traci
R Lyons, Erin Giles, Virginia Borges, Pepper Schedin. “Developmental
windows of breast cancer risk provide opportunities for targeted
chemoprevention.” Experimental Cell Research, 2013 May 9. pii:
9. Eryn B. Callihan,
Dexiang Gao, Sonali Jindal, Traci R Lyons, Elizabeth Manthey, Susan
Edgerton, Alexander Urquhart, Pepper Schedin, Virginia F. Borges. “Postpartum
Diagnosis Demonstrates a High Risk for Metastasis and Merits an Expanded
Definition of Pregnancy-Associated Breast Cancer.” Breast Cancer Research
and Treatment. 2013 Apr; 138(2):549-59.
Lyons TR, O’Brien JO, Borges VF, Conklin MW, Keely PJ, Eliceiri
KW, Marusyk A, Tan AC, Schedin, PJ. “Postpartum involution drives DCIS
progression through collagen and COX-2.” Nature Medicine.17, 1109–1115(2011).
Traci R Lyons*, Jennifer Monks, M. Scott Lucia, R. Storey Wilson, Lisa
Hines, Yan-gao Man, Virginia Borges, and Pepper Schedin. “Alternatively
activated macrophages and collagen remodeling characterize the post-partum
involuting mammary gland across species.” American Journal of Pathology. 2010
Mar;176(3):1241-55. *these authors contributed equally
Nelson AC, Lyons
TR, Young CD, Hansen KC, Anderson SM, and Holt JT. “AKT Regulates BRCA1
Stability in Response to Hormone Signaling.” Molecular
Cellular Endocrinology. 2010 May 5; 319(1-2):129-42.
Traci R Lyons, Pepper J Schedin, Virginia F Borges.
“Pregnancy and Breast Cancer: When They Collide” Journal of Mammary Gland
Biology and Neoplasia, Vol. 14, No. 2. 2009, pp. 87-98.
, Ori Maller, Shauntae McDaniel, Kirk C. Hansen, Karla J. Hedman, Traci
R Lyons, Scott Lucia, Storey Wilson, and Pepper Schedin. “Tamoxifen induces
pleiotrophic changes in mammary stroma resulting in extracellular matrix that
suppresses transformed phenotypes” Breast Cancer Research, 2009, Vol 11
Traci R Lyons, Jackie Thorburn, Philip W. Ryan, Andrew Thorburn,
Steven M. Anderson, and C. Kenneth Kassenbrock. “Regulation of the
Pro-apoptotic Scaffolding Protein POSH by Akt.” Journal of Biological
Chemistry. 2007; 282(30):21987-97.
Lyons T, Murray KE, Roberts AW, and Barton, DJ.
“Poliovirus 5’-terminal cloverleaf RNA is required in-cis for VPg uridylylation
and the initiation of negative strand RNA synthesis.” Journal of Virology,
2001, 75 (22) 10696-10708.