University of Colorado, Boulder, CO-1989
Dr Schedin was recruited to the clinical breast cancer program at UCD in 2004 for her expertise in the fields of breast cancer prevention and stromal-epithelial interactions.
Dr Schedin was recruited to the clinical breast cancer program at UC Denver in 2004 for her expertise in the fields of breast cancer prevention and stromal-epithelial interactions.
The Schedin Lab is focused on developing
breast cancer chemopreventive strategies that are targeted to specific windows
of breast development. Our approach is to understand the role of tissue
remodeling in mediating epithelial cell function during key windows of normal
mammary gland differentiation, such as occurs with adolescent gland development,
the pregnancy, lactation, and involution cycle and menopause. Major areas of
investigation include mammary epithelial cell/stromal interactions, pregnancy-associated
breast cancer, tumor dormancy/metastasis, and chemoprevention using rodent
models, 3-dimensional culture, and human breast tissue.
Schedin P and Keely, PJ. Mammary Gland ECM Remodeling, Stiffness, and the Role of Force in Normal Development and Tumor Progression. The Biology of The Mammary Gland, Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a003228. doi: 10.1101/cshperspect.a003228. Review.
- Lyons TR*, O’Brien J*, Borges V, Conklin MW, Keely PJ, Elicieri KW, Marusyk A, Tan AC, and Schedin P. Postpartum mammary gland involution drives DCIS progression through collagen and COX-2, Nature Medicine 2011, 17: 1109-1116; doi:10:1038/nm.2416, Highlighted; F1000, Commentary: T. Tlsty, Cancer Cell, 20: 285-286, September 13, 2011, SABCS 2011 Annual Meeting as a Most Important Scientific Contribution of 2011
- O’Brien J, Martinson H, Durand-Rougely C and Schedin P. Macrophages are critical for epithelial cell apoptosis and adipocyte repopulation during mammary gland involution, Development. 2012 Jan;139(2):269-75.
Borges V and Schedin P. Could NSAIDs become a preventive therapy in pregnancy-associated breast cancer? Breast Cancer Manage, (2012) 1(1), 39-46.
O'Brien JH, Vanderlinden LA, Schedin PJ*, Hansen KC. Rat Mammary Extracellular Matrix Composition and Response to Ibuprofen Treatment During Postpartum Involution by Differential GeLC-MS/MS Analysis. J. Proteome Res. 2012; 11(10):4894-905 PMID:22897585 *Corresponding Author.
Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS. Obesity and Overfeeding Affecting Both Tumor and Systemic Metabolism Activates the Progesterone Receptor to Contribute to Postmenopausal Breast Cancer. Cancer Research 2012 Dec 7; 72(24):6490-501. PMID:23222299. Selected for Journal Issue Cover Art, Highlighted in AACR Press Release, 12-7-2012
Schedin P, and Borges VF, Postpartum Diagnosis Demonstrates a High Risk for Metastasis and Merits an Expanded Definition of Pregnancy-Associated Breast Cancer, Breast Cancer Res Treat. 2013 Apr;138(2):549-59. doi: 10.1007/s10549-013-2437-x. PMID:2343022
DoD Synergy Extension
Grant: A Multidisciplinary Approach to
Pregnancy-Associated Breast Cancer, NIH NIH 1 R01 CA16416601A1: A Narrowed Window for Targeting Metabolic
Flexibility in Breast Cancer Prevention
NIH 1 R01 CA169175-01A1: NSAID during
postpartum involution for breast cancer prevention