Dr. Hirsch has worked with clinical/ translational research in lung cancer for more than 25 years. His current interest is in biomarker developments for early detection, chemoprevention and treatment of lung cancer. He is also studying markers related to molecular targeted therapies in order to understand the mechanisms of action and resistance of these new therapies, and to be able to select the patients who will benefit from such treatment.
The biomarker studies relate to the development of molecular targeted therapies for chemoprevention and treatment of lung cancer including studies on lung cancer cell lines and tumor tissue from clinical cohorts. Within the last years focus has been on identifying biomarkers, which can be used to select lung cancer patients to EGFR tyrosine kinase inhibitors and other EGFR inhibitors. Dr. Hirsch’s laboratory is currently studying biomarkers in multiple clinical trials performed in the US and Europe both in lung and head and neck cancer.
Hirsch FR, Varella-Garcia M, Bunn PA et al: Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small cell lung cancer. J Clin Oncol,24: 5034-5042. 2006.
Hirsch FR, McCoy J, West H et al: Increased EGFR gene copy number detected by FISH associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes. J Clin Oncol 23:6838-6845, 2005.
Hirsch FR and Lippman S. Advances in the biology of lung cancer prevention. J Clin Oncol 23: 3186-97, 2005.
Cappuzzo F, Hirsch FR, Rossi E. Bartolini S, Ceresoli GL, Bemis L, Haney J, Witta S, Danenberg K, Domenichini I, Ludovini V, Magrini E, Gregorc V, Doglioni C, Sidoni A, Tonato M, Franklin WA, Crino L, Bunn PA, Jr., Varella-Garcia M. Epidermal growth factor receptor gene and protein and gefitinib sensitivity non-small cell lung cancer. J Natl Cancer Inst. 97, 643-55, 2005.
Dr. Hirsch is participating in several NIH grants, and is Co-PI for one of the projects ion the Lung SPORE program as well as co-PI for the multi-institutional SPECS grant (molecular signatures of lung cancer). He is also PI for several pharmaceutical research contracts.