University of Valladolid, Spain
University Complutense, Madrid, Spain
Dr. Jimeno joined the UCD Faculty in April 2008 as the Director of the
Developmental Therapeutics/Pharmacodynamic Laboratory and as a member of the
Drug Development Program. He trained in Internal Medicine and Medical Oncology
at the University Hospital 12 de Octubre in Madrid, Spain. After completing his
training as a clinical researcher in the context of a Drug Development Clinical
Fellowship at Johns Hopkins from 2003 to 2006, Dr. Jimeno joined the Faculty at
Johns Hopkins as Instructor of Oncology in July 2006.
Antonio Jimeno, MD, PhD Research
Dr. Jimeno has developed an interest in integrating preclinical research, drug
development, and clinical research. He has made a special emphasis in 1)
developing better preclinical models, 2) determining predictors of response,
and 3) devising ways to integrate that knowledge into clinical trials to
individualize anti-cancer therapy. His concomitant work in the laboratory and
the clinic has materialized in the form of novel inventions (drugs and
biomarkers) that are currently the subject of prospective clinical testing. His
clinical interest is Head and Neck and Upper Gastrointestinal cancer. He has
been recognized for his research efforts with an ASCO Young Investigator Award
in 2005, and two ASCO Merit Awards in 2004 and 2006.
Keysar SB, Astling DP, Anderson RT, Vogler BW, Paylor JJ, Morton JJ, Paylor JJ,
Takimoto SM, Kako SL, Glogowska MJ, Sehrt DB, Le PN, Macfadden SM, Pittman MA,
Helber RA, Peterson S, Hausman D, Said S, Robinson WA, Leem TH, Goddard JA,
Arcaroli J, Messersmith WA, Hirsch F, Varella-Garcia M, Raben D, Song JI, Wang
XJ, Tan AC, Jimeno A. A direct patient tumor model of squamous cell cancer
identifies PI3K inhibitors as candidate therapeutics in the presence of human
papillomavirus, and Pi3kca or Notch1 mutations. Mol Oncol 2013.
Keysar SB, Le P, Anderson RT, Astling DP, Vogler BW, Bowles
DW, Morton JJ, Paylor JJ, Fernandez P, Glogowska MJ, Thornburn J, Takimoto S,
Sehrt D, Bowles DW, Macfadden SM, Pittman MA, Helber RA, Said S, Raben DR,
CampbellV, Kutock J, McGovern K, Thornburn A, Song JI, Tan AC, Wang XJ, Jimeno
A. The hedgehog pathway influences epidermal growth factor receptor (EGFR)
signaling dependence and acquisition of resistance to anti-EGFR therapy in head
and neck squamous cell cancer. Cancer Res 2013.
Hong DS, Bowles D, Falchook GS, Messersmith WA, Goldy G,
O’Bryant C, Herbst RS, Eckhardt SG, Vo A, Peterson S, Hausman DF, Kurzrock R,
Jimeno A. A Phase 1 study of PX-866, an irreversible, pan-isoform inhibitor of
PI3 kinase. Clin Cancer Res 2012.
Jimeno A, Weiss GJ, Miller WH, Gettinger S, Eigl B, Chang
ALS, Dunbar J, Devens S, Faia K, Skliris G, Kutok J, Lewis KD, Tibes R,
Sharfman WH, Ross RW, Rudin CM. Phase 1 Study of the Hedgehog Pathway Inhibitor
IPI-926 in Adult Patients with Solid Tumors. Clinical Cancer Res 2013.
Department of Defense CA093422