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Holly Wyatt, M.D.

Associate Professor of Medicine


Dr. Holly R. Wyatt is Associate Professor in the Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes at the University of Colorado Anschutz Medical Campus. She received her undergraduate degree for them University of Texas, her Medical Doctorate from Baylor College of Medicine in Houston, Texas and completed her internal medicine residency and endocrinology fellowship at The University of Colorado. She currently is a physician and clinical researcher at the Anschutz Health and Wellness Center (AHWC). She also runs the Metabolism and Obesity clinic at CU Anschutz where she treats overweight and obese patients.

Dr. Wyatt is currently an Associate Director for the AHWC and is in charge of the design and implementation of all clinical programs at the facility. The AHWC will be a hub of activity at the heart of the Anschutz Medical Campus and our city, setting a new global standard for an integrated, cross-disciplinary approach to creating real-life solutions for healthy lifestyles and disease prevention. Dr. Wyatt has extensive experience in weight reduction using behavioral treatment. Drs. Wyatt and Hill developed the Colorado Weigh (CW) program in 2000-2001 to provide behavioral weight management at an affordable price to the general population. CW treats weight loss and weight loss maintenance differently and prescribes different strategies for success. Over 2000 individuals have been through the CW program in the Denver area. 

Dr. Wyatt is a nationally known expert and frequent invited speaker on obesity treatment. Dr. Wyatt has been the National Program Director for the Centers for Obesity Research and Education (C.O.R.E.) since 1999. CORE was established to help educate health care professionals on how to manage obesity in their busy practices. CORE merged became a part of the education outreach for The Obesity Society (TOS) in 2010. CORE has educated over 5000 providers since its inception. Dr. Wyatt has received both a National Service Research Award and a Patient-Oriented Research Career Development Award (k23) from the National Institutes of Health to study energy metabolism and metabolic factors associated with weight loss in reduced-obese subjects.

Dr. Wyatt’s research interests include measuring resting energy expenditure, fat oxidation, total energy expenditure and activity levels in a weight reduced population. Dr Wyatt also studies how diet composition affects long-term success in weight loss maintenance.  She has studied subjects who are losing weight with the Atkins’ (low carbohydrate) vs. a low fat, high carbohydrate diet. She has also investigated diet composition, exercise patterns and breakfast consumption in the National Weight Control Registry.


  • Obesity
  • Metabolism
  • Physical Activity
  • Body Weight Regulation

Selected Publications

  1. Cluster analysis of the National Weight Control Registry to identify distinct subgroups maintaining successful weight loss.
    Ogden LG, Stroebele N, Wyatt HR, Catenacci VA, Peters JC, Stuht J, Wing RR, Hill JO.
    Obesity (Silver Spring). 2012 Apr 3. doi: 10.1038/oby.2012.79. [Epub ahead of print]
  2. Obesity: overview of an epidemic.
    Mitchell NS, Catenacci VA, Wyatt HR, Hill JO.
    Psychiatr Clin North Am. 2011 Dec;34(4):717-32. Review.
  3. Relationship Between Treatment Preference and Weight Loss in the Context of a Randomized Controlled Trial.
    Borradaile KE, Halpern SD, Wyatt HR, Klein S, Hill JO, Bailer B, Brill C, Stein RI, Miller Iii BV, Foster GD.
    Obesity (Silver Spring). 2011 Jul 14. doi: 10.1038/oby.2011.216. [Epub ahead of print]
  4. Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity.
    Higgins JA, Jackman MR, Brown IL, Johnson GC, Steig A, Wyatt HR, Hill JO, Maclean PS.
    Nutr Metab (Lond). 2011 Jul 7;8:49.
  5. Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain.
    Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, MacLean PS.
    Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R656-67. Epub 2011 Jun 29.
  6. Change in food cravings, food preferences, and appetite during a low-carbohydrate and low-fat diet.
    Martin CK, Rosenbaum D, Han H, Geiselman PJ, Wyatt HR, Hill JO, Brill C, Bailer B, Miller BV 3rd, Stein R, Klein S, Foster GD.
    Obesity (Silver Spring). 2011 Oct;19(10):1963-70. doi: 10.1038/oby.2011.62. Epub 2011 Apr 14.
  7. Physical activity patterns using accelerometry in the National Weight Control Registry.
    Catenacci VA, Grunwald GK, Ingebrigtsen JP, Jakicic JM, McDermott MD, Phelan S, Wing RR, Hill JO, Wyatt HR.
    Obesity (Silver Spring). 2011 Jun;19(6):1163-70. Epub 2010 Oct 28.
  8. Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial.
    Foster GD, Wyatt HR, Hill JO, Makris AP, Rosenbaum DL, Brill C, Stein RI, Mohammed BS, Miller B, Rader DJ, Zemel B, Wadden TA, Tenhave T, Newcomb CW, Klein S.
    Ann Intern Med. 2010 Aug 3;153(3):147-57.
  9. Pedometer-measured physical activity and health behaviors in U.S. adults.
    Bassett DR Jr, Wyatt HR, Thompson H, Peters JC, Hill JO.
    Med Sci Sports Exerc. 2010 Oct;42(10):1819-25.
  10. Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet.
    Hernandez TL, Sutherland JP, Wolfe P, Allian-Sauer M, Capell WH, Talley ND, Wyatt HR, Foster GD, Hill JO, Eckel RH.
    Am J Clin Nutr. 2010 Mar;91(3):578-85. Epub 2010 Jan 27.
  11. Using the energy gap to address obesity: a commentary.
    Hill JO, Peters JC, Wyatt HR.
    J Am Diet Assoc. 2009 Nov;109(11):1848-53. No abstract available.
  12. The obesity epidemic.
    Catenacci VA, Hill JO, Wyatt HR.
    Clin Chest Med. 2009 Sep;30(3):415-44, vii. Review.

  • ​Obesity
  • General Endocrinology

Medical Schools
MD, Baylor College of Medicine, Houston, TX (1993)

Undergraduate School
B.A., University of Texas, Austin, TX (1989)

University of Colorado, Denver, CO (1993-1995)

University of Colorado, Denver, CO (1995-1999)




Carrie Brill Senior Professional Research Assistant


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