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Margaret E. Wierman, M.D.

Professor of Medicine, Physiology and Biophysics, Chief of Endocrinology, Denver VAMC

Dr. Wierman received her MD and residency training at at Baylor College of Medicine. Her fellowship and research training was at Massachusetts General Hospital and the Brigham and Women’s Hospital at Harvard University. She has been a faculty member at the University of Colorado since 1987 and her expertise is in reproductive and neuroendocrinology. Dr. Wierman’s research interests are in the regulation of the genes that control the reproductive axis. She studies the mechanisms by which gonadal sex steroids and peptide hormones regulate the expression of the gonadotropin releasing hormone (GnRH). The major goal of her work is to define the mechanisms by which GnRH neuronal development is controlled in order to gain a deeper understanding of the pubertal process, infertility, and hypogonadism. The other focus of the lab is to understand the mechanisms of pituitary tumorigenesis. Translational studies are identifying new genes that cause or are markers of pituitary tumor. Both cellular and transgenic animal models as well as human studies are ongoing. Collaborative projects with other investigators at UCDHSC include the role of sex hormones in body weight distribution at menopause and sex hormone effects on HIV transmission and progression in women.​

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  • GnRH neuron development, survival migration & gene expression
  • Molecular pathogenesis of pituitary tumors
  • Neuroendocrine dysfunction after traumatic brain injury
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Selected Publications

  1. Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer.
    Weickhardt AJ, Rothman MS, Salian-Mehta S, Kiseljak-Vassiliades K, Oton AB, Doebele RC, Wierman ME, Camidge DR.
    Cancer. 2012 Apr 4. doi: 10.1002/cncr.27450. [Epub ahead of print]
  2. Clinical implications of growth hormone-secreting tumor subtypes.
    Kiseljak-Vassiliades K, Shafi S, Kerr JM, Phang TL, Kleinschmidt-Demasters BK, Wierman ME.
    Endocrine. 2012 Mar 21. [Epub ahead of print]
  3. Extracellular Signal-Regulated Kinase 1 and 2 Are Not Required for GnRH Neuron Development and Normal Female Reproductive Axis Function in Mice.
    Wierman ME, Xu M, Pierce A, Bliesner B, Bliss SP, Roberson MS.
    Neuroendocrinology. 2011 Dec 9. [Epub ahead of print]
  4. CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women.
    Meditz AL, Moreau KL, MaWhinney S, Gozansky WS, Melander K, Kohrt WM, Wierman ME, Connick E.
    J Acquir Immune Defic Syndr. 2012 Mar 1;59(3):221-8.
  5. Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.
    Michaelis KA, Knox AJ, Xu M, Kiseljak-Vassiliades K, Edwards MG, Geraci M, Kleinschmidt-DeMasters BK, Lillehei KO, Wierman ME.
    Endocrinology. 2011 Oct;152(10):3603-13. Epub 2011 Aug 2.
  6. Giant pituitary adenomas: pathologic-radiographic correlations and lack of role for p53 and MIB-1 labeling.
    Madsen H, Borges TM, Knox AJ, Michaelis KA, Xu M, Lillehei KO, Wierman ME, Kleinschmidt-DeMasters BK.
    Am J Surg Pathol. 2011 Aug;35(8):1204-13.
  7. Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice.
    Pierce A, Xu M, Bliesner B, Liu Z, Richards J, Tobet S, Wierman ME.
    Mol Cell Endocrinol. 2011 Jun 6;339(1-2):151-8. Epub 2011 Apr 22.
  8. How should postmenopausal androgen excess be evaluated?
    Rothman MS, Wierman ME.
    Clin Endocrinol (Oxf). 2011 Aug;75(2):160-4. doi: 10.1111/j.1365-2265.2011.04040.x. Review.
  9. Pituitary apoplexy.
    Kerr JM, Wierman ME.
    BMJ. 2011 Mar 17;342:d1270. doi: 10.1136/bmj.d1270. No abstract available.
  10. Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry.
    Rothman MS, Carlson NE, Xu M, Wang C, Swerdloff R, Lee P, Goh VH, Ridgway EC, Wierman ME.
    Steroids. 2011 Jan;76(1-2):177-82. Epub 2010 Nov 9.
  11. Transsphenoidal resection of 82 Rathke cleft cysts: limited value of alcohol cauterization in reducing recurrence rates.
    Lillehei KO, Widdel L, Astete CA, Wierman ME, Kleinschmidt-DeMasters BK, Kerr JM.
    J Neurosurg. 2011 Feb;114(2):310-7. Epub 2010 Aug 27.
  12. Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive function.
    Wierman ME, Kiseljak-Vassiliades K, Tobet S.
    Front Neuroendocrinol. 2011 Jan;32(1):43-52. Epub 2010 Jul 30. Review.

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  • ​Reproductive Endocrinology
  • Neuroendocrinology
  • Pituitary Disease
  • Disorders of Adolescence and Menopause and Hypogonadism in Men and Women ​

Medical Schools
M.D., Baylor College of Medicine (1979)

Internships
Baylor College of Medicine Program (1980)

Residency Program
Baylor College of Medicine Program, Chief Resident, Internal Medicine (1983)

Fellowships
Massachusetts General Hospital/Brigham and Women's Hospital Program, Internal Medicine - Endocrinology, Diabetes, and Metabolism (1987)


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​ Katja Kiseljak-Vassiliades, D.O.​ Instructor of Medicine
​ Smita Mehta, Ph.D.​ Postdoctoral Fellow
​ Mei Xu Professional Research Assistant

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