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Neda Rasouli, M.D.

Associate Professor of Medicine

Dr. Rasouli received her MD degree from Tehran University of Medical Sciences, Iran. Her internal medicine residency training was at Michigan State University, Lansing, MI and she completed her endocrinology fellowship at the University of Arkansas for Medical Sciences, Little Rock, AR, in 2002. Dr Rasouli joined the faculty of the University of Colorado, Denver in 2009. Dr. Rasouli is a physician and a translational researcher at the University of Colorado and Eastern Colorado Veterans Health Care System. Dr Rasouli has special interest in the management and treatment of patients with diabetes and metabolic disorders associated with obesity. Her research interests include studying the pathophysiology of insulin resistance particularly molecular mechanisms involved in adipose tissue inflammation and lipotoxicty associated with obesity and insulin resistance. Among the current projects in Dr Rasouli’s laboratory is an investigation on effects of different PPAR ligands on adipose tissue inflammation particularly the number and phenotype of macrophages resident in adipose tissue. In addition, Dr Rasouli is interested in the role of adipose tissue hypoxia in the pathogenesis of insulin resistance.​

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  • Diabetes
  • Metabolic disorders associated with obesity
  • Insulin Resistance
  • Lipotoxicity and adipose tissue inflammation associated with obesity and insulin resistance
  • PPAR ligands on adipose tissue inflammation

Selected Publications

  1. Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts.
    Rasouli N, Kern PA, Elbein SC, Sharma NK, Das SK.
    Pharmacogenet Genomics. 2012 Mar 19. [Epub ahead of print]
     
  2. Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy.
    Hsia E, Seggelke SA, Gibbs J, Rasouli N, Draznin B.
    Nutr Clin Pract. 2011 Dec;26(6):714-7.
     
  3. Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance.
    Spencer M, Unal R, Zhu B, Rasouli N, McGehee RE Jr, Peterson CA, Kern PA.
    J Clin Endocrinol Metab. 2011 Dec;96(12):E1990-8. Epub 2011 Oct 12.
     
  4. Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI.
    Elbein SC, Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK.
    Diabetes. 2011 Mar;60(3):1019-29. Epub 2011 Jan 24.
     
  5. Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone.
    Yao-Borengasser A, Varma V, Coker RH, Ranganathan G, Phanavanh B, Rasouli N, Kern PA.
    Metabolism. 2011 Jul;60(7):1012-20. Epub 2010 Dec 3.
     
  6. Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.
    Spencer M, Yao-Borengasser A, Unal R, Rasouli N, Gurley CM, Zhu B, Peterson CA, Kern PA.
    Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1016-27. Epub 2010 Sep 14.
     
  7. Insulin resistance in African-American and Caucasian women: differences in lipotoxicity, adipokines, and gene expression in adipose tissue and muscle.
    Smith LM, Yao-Borengasser A, Starks T, Tripputi M, Kern PA, Rasouli N.
    J Clin Endocrinol Metab. 2010 Sep;95(9):4441-8. Epub 2010 Jun 30.
     
  8. Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone.
    Unal R, Yao-Borengasser A, Varma V, Rasouli N, Labbate C, Kern PA, Ranganathan G.
    J Clin Endocrinol Metab. 2010 Jun;95(6):2993-3001. Epub 2010 Apr 14.
     
  9. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans.
    Rasouli N, Yao-Borengasser A, Varma V, Spencer HJ, McGehee RE Jr, Peterson CA, Mehta JL, Kern PA.
    Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1328-35. Epub 2009 Aug 10.
     
  10. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.
    Varma V, Yao-Borengasser A, Rasouli N, Nolen GT, Phanavanh B, Starks T, Gurley C, Simpson P, McGehee RE Jr, Kern PA, Peterson CA.
    Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1300-10. Epub 2009 Mar 31.
     
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  • Diabetes
  • Metabolic disorders
  • Obesity​

Medical Schools
MD, Tehran University of Medical Sciences, Iran (1995)

Residency Program
Michigan State University Program, Internal Medicine (2000)

Fellowships
University of Arkansas for Medical Sciences Program, Internal Medicine - Endocrinology, Diabetes, and Metabolism (2002)


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​Name

​Title

​ ​ Chantal Underkofler​ Professional Research Assistant/Clinical Study Trial Coordinator
​ ​ Sara Douglass, PA-C Instructor of Medicine
​ ​ Ryan Loesch Professional Research Assistant

​Indication

​Study Title

​Contact Name

​Contact Info

Pre-Diabetes​ Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation Chantal Underkofler​ 303-399-8020 x 2059
Healthy Lean Individuals, Healthy Obese Individuals, and Obese Pre-Diabetics​ ​Effects of Adipose Tissue Hypoxia on the Development of Insulin Resistance Chantal Underkofler​​ 303-399-8020 x 2059
Type II Diabetes ​Exenatide Study of Cardiovascular Event Lowering Trial Chantal Underkofler​​ ​303-399-8020 x 2059