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Edward Melanson, Ph.D.

FACSM, Associate Professor of Medicine

Dr. Melanson began his research career as a post-doctoral fellow in the Center for Human Nutrition in 1998, and received a faculty appointment in the Division in 2003. His research interests are the effects of diet, exercise, and obesity on substrate metabolism and energy expenditure. Currently, Dr. Melanson is performing studies on the effects of different intensities of exercise and manipulations in dietary fat on fat oxidation. These studies are performed using whole-room indirect calorimetry. He also is currently performing an exercise intervention aimed at determining the effects of exercise on the different components of energy expenditure, particularly non-resting energy expenditure. In these studies, a variety of approaches are used to assess energy expenditure including doubly labeled water, indirect calorimetry, and accelerometry. Dr. Melanson's research is funded by the NIH.

Dr. Melanson is an Assistant Director of the Energy Balance Core Lab. In this capacity, he oversees the operation of the whole-room calorimeter, located on the Clinical Translational Research Center (CTRC).

Selected Publications 

  • Melanson EL, Dykstra JC, Szuminsky N. A novel approach for measuring energy expenditure in free-living humans. Conf Proc IEEE Eng Med Biol Soc. 2009;1:6873-7. PUBMED

  • Melanson EL, Gozansky WS, Barry DW, Maclean PS, Grunwald GK, Hill JO. When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals. J Appl Physiol. 2009 Dec;107(6):1847-56. PUBMED

  • Melanson EL, Astrup A, Donahoo WT. The relationship between dietary fat and fatty acid intake and body weight, diabetes, and the metabolic syndrome. Ann Nutr Metab. 2009;55(1-3):229-43. PUBMED

  • MacLean PS, Higgins JA, Wyatt HR, Melanson EL, Johnson GC, Jackman MR, Giles ED, Brown IE, Hill JO. Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R793-802 PUBMED

  • Christensen R, Lorenzen JK, Svith CR, Bartels EM, Melanson EL, Saris WH, Tremblay A, Astrup A. Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials. Obes Rev. 2009 Jul;10(4):475-86. PUBMED

  • Sazonov ES, Schuckers SA, Lopez-Meyer P, Makeyev O, Melanson EL, Neuman MR, Hill JO. Toward objective monitoring of ingestive behavior in free-living population. Obesity (Silver Spring). 2009 Oct;17(10):1971-5. PUBMED

  • Melanson EL, MacLean PS, Hill JO.Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidation. Exerc Sport Sci Rev. 2009 Apr;37(2):93-101. PUBMED

  • Volpe SL, Melanson EL, Kline G. Validation of bioelectrical impedance analysis to hydrostatic weighing in male body builders. Acta Diabetol. 2009. PUBMED

  • Sazonov E, Schuckers S, Lopez-Meyer P, Makeyev O, Sazonova N, Melanson EL, Neuman M. Non-invasive monitoring of chewing and swallowing for objective quantification of ingestive behavior. Physiol Meas. 2008 May;29(5):525-41. PUBMED

  • Melanson EL, Donahoo WT, Grunwald GK, Schwartz R. Changes in 24-h substrate oxidation in older and younger men in response to exercise. J Appl Physiol. 2007 Nov;103(5):1576-82. PUBMED


Coming Soon!

Reasearch Interests


·        Obesity

·        Energy Metabolism​