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Audrey Bergouignan, PhD

Assistant Professor of Medicine, Division of Endocrinology, Metabolism and Diabetes




Bio

I am a researcher at the French National Center for Scientific Research (CNRS) with a joint appointment at the Division of Endocrinology, University of Colorado. I am also the leader of an International Laboratory Agreement (CNRS LIA, 2017-2022) between the CNRS and the University of Colorado, Division of Endocrinology, Anschutz Health & Wellness Center. The LIA is a 5-year international collaborative research program on the global transition of physical activity. My research aims to (1) understand the mechanisms by which sedentary behaviors contribute to the development and progression of metabolic diseases and to (2) develop preventive strategies for the metabolic alterations induced by sedentariness that can be implemented in our daily life. I have a solid experience in clinical research devoted to study the effect of lifestyle (physical inactivity/activity and diet) on metabolism and body weight regulation. I have substantial expertise in measuring energy and nutrient metabolism, physical activity and sedentary behaviors using whole-room calorimetry, indirect calorimetry, doubly labeled water, tracer techniques of nutrient pathways and accelerometry-based physical activity monitors. By combining studies performed in controlled lab setting and in free-living conditions, my approach is translational and aims to ultimately provide with solid and objective evidence to help refining future public health guidelines on physical activity, and thus prevent future generations from the development of chronic diseases. I have also obtained several awards and fellowships in three different countries, including a NIH/NIDDK K99/R00 award to investigate the role of sedentary behaviors in the development of metabolic diseases, 2014-2019 (Mentor: Bessesen).
 
  Articles published in peer-reviewed journals Articles published in peer-reviewed journals 
  Students, *1st co-authors, #last co-authors
 
1. Rynders CA, Schmidt SL, Bergouignan A, Horton TJ, Bessesen DH. Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males. Physiological Reports, in press.

2. Lefai E*, Blanc S*, Antoun E, Momken I, Chery I, Zahariev A, Gabert L, Bergouignan A#, Simon C#. Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype. Int J Obes (Lond). 2017 Jul 3. doi: 10.1038/ijo.2017.151. PMID:28669989

3. Rynders CA, Blanc S, DeJong NS, Bessesen DH, Bergouignan A. Sedentary behaviors as a key determinant of metabolic flexibility. J Physiol, 2017 May 24. doi: 10.1113/P273282. Review on invitation

4. Rynders CA, Bergouignan A, Kealey E, Bessesen DH. Ability to adjust nocturnal fat oxidation in response to overfeeding predicts 5-year weight gain in adults. Obesity. 2017 May;25(5):873-880. Doi: 10.1002/oby.21807. Editorial pick-up

5. Bergouignan A, Legget KT, De Jong N, Kealey EA, Nikolovski J, Groppel JL, Jordan C, O’Day R, Hill JO, Bessesen DH. Effect of frequent interruptions of prolonged sitting on self-perceived levels of energy, mood, food cravings and cognitive function. Int J Behav Phys Act Diet, 2016. 13:113. DOI: 10.1186/s12966-016-0437-z. Press release.

6. Gastebois C, Villars C, Drai J, Canet-Soulas E, Blanc S, Bergouignan A, Lefai E, Simon C. Effects of training and detraining on plasma adiponectin concentrations and muscle sensitivity in lean and overweight men. Eur J Appl Physiol, 2016 Sep 8 [Epub ahead of print].

7. Bergouignan A, Latouche C, Heywood S, Grace M, Natoli A, Luthoodoo M, Owen N, Dunstan DW, Kingwell BA. Frequent interruption of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in skeletal muscle. Sci Report, 2016 Aug 24;6:32044. doi: 10.1038/srep32044

8. Bergouignan A, Stein PT, Coxam V, O’Gorman D, Blanc S. Towards Human Exploration in Space: The THESEUS review series on nutrition and metabolism research priorities. npg Microgravity, 2016. 2:16029

9. Rudwill F*, Bergouignan A*, Gastebois C, Gauquelin-Koch G, Lefai, E, Blanc S, Simon C. Effect of enforced physical inactivity by 60-d of bed rest on hepatic markers of NAFLD in healthy normal-weight women. Liver Int. 2015 Jun;35(6):1700-6. doi: 10.1111/liv.12743.

10. Bergouignan A, Kealey E, Jackman MR, Bessesen DH. Twenty-four hour total and dietary fat oxidation in lean, obese and reduced-obese adults with and without a bout of exercise. PloS One. 2014 Apr 8;9(4):e94181.
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Sedentary behaviors; physical inactivity; habitual physical activity; exercise; integrative physiology; obesity; metabolic flexibility; metabolic diseases; nutrition; energy balance; energy metabolism; lipid metabolism; fatty acid trafficking; mitochondrial function; stable isotope labeling techniques; mass spectrometry; indirect calorimetry; high-resolution respirometry; accelerometers; microgravity; space science; ecology of health; ecophysiology; comparative physiology.

2014-2016       Post-Doctoral Training in Integrative Physiology and Metabolism
                       University of Colorado Denver Anschutz Medical Campus
                       Division of Endocrinology, Metabolism and Diabetes, Denver CO, USA.
                       Mentor: Daniel Bessesen, MD

11/13-08/14     Post-Doctoral Training in Sedentary Behavior 
                       Baker IDI Heart & Diabetes Institute, Melbourne, Australia. 
                       Mentors: Neville Owen, PhD, David Dunstan, PhD, Bronwyn Kingwell, PhD.

2009-2013       Post-Doctoral Training in Obesity and Metabolism
                       University of Colorado Denver Anschutz Medical Campus
                       Center for Human Nutrition, Denver, CO, USA.
                       Mentors: James Hill, PhD, Dan Bessesen, MD, Paul McLean PhD, Ed Melanson PhD.

2008                PhD in Physiology and Biology of the Organisms
                       University of Strasbourg, France.
                       Mentors: Chantal Simon, MD, Stéphane Blanc, PhD.

2004                M.S in Ecophysiology, Energetics and Behavior - Louis Pasteur University, France.

2002                B.S in Biology of the Populations and Organisms - University of Aix-Marseille III, France.