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Linda Barbour, M.D., M.S.P.H

Professor of Medicine and Obstetrics and Gynecology


Dr. Barbour completed medical school at the University of Colorado in 1984​ and accepted an internal medicine residency at the same institution from 1984-1987. She joined the faculty in the division of General Internal Medicine in 1987 and received a co-appointment in the Department of Obstetrics and Gynecology as an assistant professor in 1991 due to her role as medicine consultant for High Risk Obstetrics and Co-Director of their High Risk OB and Diabetes in Pregnancy Clinics. In 1992, she completed a fellowship in the Department of Preventive Medicine and Biometrics and received a Masters of Science in Public Health. Dr. Barbour was promoted to associate professor in Medicine and Obstetrics and Gynecology in 1996 with joint positions in the General Internal Medicine division and Maternal-Fetal-Medicine division , and has been listed in Best Doctors in America every year since that time. Due to her increasing interest in the area of endocrinology of pregnancy and translational research, she left the General Internal Medicine division in July of 1999 and pursued a fellowship at UCHSC in the division of Endocrinology, Metabolism, and Diabetes. She completed the three year fellowship in June of 2002, became board certified in Endocrinology, and was promoted in 2008 to full professor in the divisions of Endocrinology, Metabolism, and Diabetes and Maternal-Fetal-Medicine. She was awarded a K-23 grant to study insulin signaling in women with gestational diabetes during pregnancy and in the postpartum period. Recently, she was awarded an NIH R-01 grant to better understand what excess nutrients in mothers who are obese or have had gestational diabetes might program obesity in the newborn. She is past President of the North American Society of Obstetric Medicine, has served on the Pregnancy Council for the American Diabetes Association, and chaired the Colorado Clinical Guidelines Collaborative for the Manag​ement of Gestational Diabetes for the state health department. She has published over 50 manuscripts, book chapters, and guidelines in the area of Obstetric Medicine and is a co-editor of the textbook “Medical Care of the Pregnant Patient”, for which the 2 nd edition was published by the ACP in 2008, and a co-author of the Endocrine Society Guidelines on Thyroid Dysfunction in Pregnancy and Postpartum , published in 2007 and 2012.  She is also the Co-Director of the Colorado Program in Nutrition and Healthy Development, an initiative to foster the collaboration of multidisciplinary senior and junior investigators in translational research to study how the intrauterine and early postnatal environment can be positively modified to attenuate the risk of pediatric obesity and metabolic syndrome.  ​

​​

  • Endocrine Disorders in Pregnancy
  • Obesity and Diabetes and Pregnancy
  • Fetal Programming of Obesity

Selected Publications​

  1. Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.
    Barbour LA, Van Pelt RE, Brumbaugh DE, Hernandez TL, Friedman JE.
    Diabetes Care. 2012 Mar;35(3):e28; author reply e30. No abstract available.
  2. Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet: metabolic determinants of fetal growth.
    Harmon KA, Gerard L, Jensen DR, Kealey EH, Hernandez TL, Reece MS, Barbour LA, Bessesen DH.
    Diabetes Care. 2011 Oct;34(10):2198-204. Epub 2011 Jul 20.
  3. Patterns of glycemia in normal pregnancy: should the current therapeutic targets be challenged?
    Hernandez TL, Friedman JE, Van Pelt RE, Barbour LA.
    Diabetes Care. 2011 Jul;34(7):1660-8. Review. No abstract available.
  4. Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum.
    Barbour LA, McCurdy CE, Hernandez TL, Friedman JE.
    J Clin Endocrinol Metab. 2011 May;96(5):1431-41. Epub 2011 Feb 2.
  5. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil.
    Heerwagen MJ, Miller MR, Barbour LA, Friedman JE.
    Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R711-22. Epub 2010 Jul 14. Review.
  6. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline.
    Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ, Stagnaro-Green A.
    J Clin Endocrinol Metab. 2007 Aug;92(8 Suppl):S1-47.
  7. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes.
    Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE.
    Diabetes Care. 2007 Jul;30 Suppl 2:S112-9. No abstract available. Erratum in: Diabetes Care. 2007 Dec;30(12):3154.
  8. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.
    del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.
    Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.
  9. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
    Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.
    J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.
  10. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.
    Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B.
    Endocrinology. 2004 Mar;145(3):1144-50. Epub 2003 Nov 21.
​​
  • Medical Disorders During Pregnancy
  • Diabetes in Pregnancy
  • Thyroid/Metabolic Bone Disease
  • General Endocrinology

Medical Schools
MD, University of Colorado Denver School of Medicine (1984)

Fellowships
University of Colorado, Internal Medicine - Endocrinology, Diabetes, and Metabolism (2002)

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Picture

Name

Title

Melanie Reece, PhD​ Senior Professional Research Assistant
Catherine Chartier-Logan Professional Research Assistant

Indication

​Study Title

​Contact Name

​Contact Info

Obesity​ Regulation of Maternal Fuel Supply and Infant Adiposity Molly Krause 303.724.3954

Gestational Diabetes - 

Obesity, Type 2 DM-  ​

Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes in Gestational Diabetes

Impact of Maternal Obesity and Diabetes on Breast Milk Composition and Infant Adiposity 

 

Teri Hernandez, PhD, RN

Bridget Young, PhD​​

​303.724.3943

 

303-724-3309