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Stephen C. Dreskin, MD, PhD - Professor

Division of Allergy and Clinical Immunology


Stephen Dreskin

Director, University of Colorado Allergy, Immunology and Rheumatology Practices

Co-director, University of Colorado/National Jewish - Allergy/Clinical Immunol. training program

Medical Director & Clinical Consultant, Clinical Immunology/Flow Cytometry Lab, ClinImmune Labs

Assistant Medical Director, Colorado Cord Blood Bank, ClinImmune Labs

 

12700 E. 19th Avenue, B164, R2
Aurora, CO 80045
Research Office Phone:     303-724-7190
Research Fax:                   303-724-7212 
E-mail:  Stephen.Dreskin@ucdenver.edu

Headlines:

5280 Top Doctors at UCH

New Procedure Helps Hospital Fight Antibiotic Allergies. UCH Insider.

 

1971 BA (Biochemistry) University of Pennsylvania

1976 PhD (Physiology) Emory University

1977 MD (Medicine) Emory University

1977-78 Internship (Internal Medicine) University of California-Davis

1978-80 Residency (Internal Medicine) University of California-Davis

1981-85 Fellowship - National Institute of Allergy & Infections Diseases (NIAID), NIH, Bethesda, MD

 

Board Certification:

1980 Internal Medicine

1983 Allergy and Immunology

1990 Diagnostic Laboratory Immunology

Severe allergic reactions, severe food allergies

Chronic Urticaria

Angioedema

Anaphylaxis

Mastocytosis

Asthma and Rhinitis

Allergic Reactions to Vaccines

Allergy and Immunology Practice 

Clinic Location:

University of Colorado Allergy, Immunology and Rheumatology Practice

1635 Aurora Court
5th Floor, Anschutz Outpatient Pavilion
Aurora, CO 80045

 

Clinic Days:

These are teaching clinics. Dr. Dreskin does not have a "private" clinic. Often, patients will first be evaluated by an MD who is taking subspecialty training in Allergy and Immunology. Dr. Dreskin can be requested to be the "Attending of Record".

Dr. Dreskin is in clinic most Monday afternoons, Thursday mornings, and Friday mornings.

 

Appointment Contact:

Call 720-848-7600

Clinic Fax: 720-848-1713

For more information please see Dr. Dreskin's profile at CUDoctors.com.

Molecular basis of peanut allergy

Study of functional IgE-allergen interactions as they pertain to food allergies

Molecular basis of chronic urticaria

The primary effort in the Dreskin laboratory is to understand the effector activity of peanut allergens (funded by the National Institutes of Allergy and Infectious Diseases, NIH RO1AI052164).  Allergic reactions to peanuts occur because susceptible individuals have an aberrant response to peanuts by producing a plasma protein, IgE, that binds to the high affinity receptor for IgE on mast cells and basophils.  This receptor-bound IgE can be cross-linked by specific peanut proteins, called allergens, leading to a severe allergic reaction.  Eleven peanut proteins have been identified as allergens because they bind IgE from allergic individuals. Based on our work and the work of others, we now know that Ara h 2 and Ara h 6 are the most potent of these allergens for most patients.  We have championed the concept of defining the clinically most important allergens based on potency in functional assays that we have helped to develop.  Our newest data examining the allergenicity of peanut extracts that have been specifically depleted of Ara h 2  and Arah 6 demonstrate strongly that, for severely peanut allergic patients, the activity of Ara h 2 and Ara h6 together account for the approximately 90% of the allergenic activity of peanuts.  We propose to define in molecular detail how these peanut allergens interact to be responsible for mast cell activation in peanut allergic patients. We are currently testing our in vitro findings in vivo using a mouse model of peanut allergy. This approach has changed our thinking as to which peanut allergens are the most important for allergic reactions. 

 

Research Team:

Xueni Chen,  MD, PhD

Daphne Moutsoglou, BS

 

Active Collaborators at UCDenver:

Mark Duncan, PhD

Kirk Hansen, PhD

Porterfield HS, Murray KS, Schlichting DG , Chen X, Hansen KC, Duncan MW, and Dreskin SC.  Effector Activity of Peanut Allergens: A critical role for Ara h 2, Ara h 6, and their variants.  Clinical and Experimental Allergy.  2009; 39:1099-1108.

McDermott RA, Porterfield HS, El Mezayan R, Burks AW, Schlichting D, Solomon B, Redzic JS, Harbeck RJ, Duncan MW, Hansen KC, Dreskin SC.  Contribution of Ara h 2 to peanut-specific immunoglobulin E-mediated, cell activation.  Clinical and Experimental Allergy.  2007; 37:752-763.

Dreskin, SC.  “Urticaria and Angioedema” in Cecil’s Textbook of Medicine.  2008; 1942-1946.

Amar, S and Dreskin, SC.  Urticaria and Angioedema.  Primary Care: Clinics in Office Practice.  2008; 35(1):141-57.

Mustafa, SS and Dreskin, SC.  Urticaria and Angioedema.  ePocrates.  2009.