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Department of Radiology

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C-TRIC Lecture Series


The C-TRIC Lecture Series  . . .

C-TRIC Lecture Series for 2013:


André Carpentier, MD, FRCPC, CSPQ

Date: January 23rd

Time: 12-1pm

Place: Academic Office Building (AO1) Room L15-7000 (Board Room)


"Positron emission tomography for the investigation of adipose tissue dysfunctions in type 2 diabetes"


Ectopic fat deposition in skeletal muscles, liver, heart, and other tissues has been closely linked with the development of lean tissues’ insulin resistance and progression towards type 2 diabetes. Mechanisms of overexposure of these tissues to fatty acids include increased de novo lipogenesis, impaired fatty acid oxidation, and increased fatty acid flux to these organs. White adipose tissues are the main organs responsible for the regulation of circulating fatty acids. It has been clearly demonstrated that pre-diabetic and diabetic individuals display impaired adipose tissue dietary fatty acid storage that may lead to increased circulating flux and exaggerated lean tissue fatty acid exposure. Additionally, brown adipose tissue depots are less metabolically active in individuals with type 2 diabetes. We have developed a series of novel in vivo investigative tools using positron emission tomography to comprehensively assess postprandial inter-organ fatty acid partitioning and white and brown adipose tissue metabolism in subjects with pre-diabetes and type 2 diabetes. Our findings shed new lights into the sophisticated mechanisms that regulate fatty acid partitioning and energy homeostasis during the development of type 2 diabetes. New links between abnormal dietary fatty acid metabolism and early myocardial metabolic and functional defects are now being uncovered in humans with the hope to find novel ways to predict and avoid the devastating complications of diabetes.


Future Speakers:


Jon-Kar Zubieta

Dr. Zubieta's work focuses on the neurobiological bases of mood disorders and utilizes positron emission tomography (PET), single photon emission tomography(SPECT) and magnetic resonance imaging (MRI) as research tools.

Date: March 6th

Time: TBD

Place: TBD


Rajesh Narendran

Dr. Narendran is a Radiologist at the University of Pittsburgh whose research focuses on imaging of neurotransmitters in psychiatric disorders with positron emission tomography.

Date: July 19th

Time: TBD

Place: TBD


Hank Kung

Dr. Kung is a professor of Radiology at the University of Pennsylvania and his research focuses on the development of radiopharmaceuticals used in the diagnosis of degenerative neurological diseases.

Date: September 18th

Time: TBD

Place: TBD