C-TRIC Lecture Series for 2013:
André Carpentier, MD, FRCPC, CSPQ
Date: January 23rd
Place: Academic Office Building (AO1) Room L15-7000 (Board
emission tomography for the investigation of adipose tissue dysfunctions in
type 2 diabetes"
deposition in skeletal muscles, liver, heart, and other tissues has been
closely linked with the development of lean tissues’ insulin resistance and
progression towards type 2 diabetes. Mechanisms of overexposure of these
tissues to fatty acids include increased de novo lipogenesis, impaired fatty
acid oxidation, and increased fatty acid flux to these organs. White adipose
tissues are the main organs responsible for the regulation of circulating fatty
acids. It has been clearly demonstrated that pre-diabetic and diabetic
individuals display impaired adipose tissue dietary fatty acid storage that may
lead to increased circulating flux and exaggerated lean tissue fatty acid
exposure. Additionally, brown adipose tissue depots are less metabolically
active in individuals with type 2 diabetes. We have developed a series of novel
in vivo investigative tools using positron emission tomography to
comprehensively assess postprandial inter-organ fatty acid partitioning and
white and brown adipose tissue metabolism in subjects with pre-diabetes and
type 2 diabetes. Our findings shed new lights into the sophisticated mechanisms
that regulate fatty acid partitioning and energy homeostasis during the
development of type 2 diabetes. New links between abnormal dietary fatty acid
metabolism and early myocardial metabolic and functional defects are now being
uncovered in humans with the hope to find novel ways to predict and avoid the
devastating complications of diabetes.
Dr. Zubieta's work focuses on the neurobiological bases of mood disorders and utilizes positron emission tomography (PET), single photon emission tomography(SPECT) and magnetic resonance imaging (MRI) as research tools.
Date: March 6th
Dr. Narendran is a Radiologist at the University of Pittsburgh whose research focuses on imaging of neurotransmitters in psychiatric disorders with positron emission tomography.
Date: July 19th
Dr. Kung is a professor of Radiology at the University of Pennsylvania and his research focuses on the development of radiopharmaceuticals used in the diagnosis of degenerative neurological diseases.
Date: September 18th