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Research in our lab is focused on understanding how the excitability of neurons is regulated by excitatory and inhibitory synaptic plasticity. Many neuropsychiatric diseases and brain pathologies exhibit alterations in neuronal excitability in key brain regions associated with learning and memory. Our goal is to understand the molecular mechanisms of how excitatory and inhibitory synapses function together to maintain appropriate excitability of the neuron, and how this is disrupted in diseases such as autism and schizophrenia.  To reach this goal we image both excitatory and inhibitory synapses using cutting-edge microscopy, including super-resolution imaging, supported by electrophysiology and biochemical analysis


The Smith lab is located in the department of Pharmacology at the University of Colorado School of Medicine.​


University of Colorado - Denver

Department of Pharmacology


12800 East 19th Ave

Aurora CO 80045


Office: P18-6117

Lab: P18-6402K

Phone: (303) 724-0267