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Department of Pharmacology

Department of Pharmacology
 

Chandra Tucker, PhD

Associate Professor


Contact Information:

University of Colorado Denver
Department of Pharmacology
Mail Stop 8303, RC1-South
12801 East 17th Ave
Aurora CO 80045

Phone: (303) 724-6337
Fax: (303) 724-3663
E-mail: chandra.tucker@ucdenver.edu
Office: RC1-South, L18-6113

curriculum vitae

Tucker Lab webpage

Affiliated Programs

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Research Overview

 

Research in the Tucker Lab focuses on the study and manipulation of protein interactions and pathways, including protein homeostasis and signaling pathways. In particular, we are interested in developing novel technologies that allow use of light for photocontrol of protein function. These engineered optogenetic tools allow regulation of molecular biochemistry and cellular behaviors in live cells with fast temporal and spatial precision. We pioneered a widely-used CRY2-CIB1 tool to control protein-protein interactions with blue light, which we are further developing and using to control diverse intracellular effectors. Other research interests include developing approaches to characterize and rescue misfolded proteins, designing new genetic assays to characterize unstable human disease proteins, and developing sensors of ligand-binding events. The approaches we take in the lab are interdisciplinary, ranging from biochemistry and protein engineering, to yeast genetics and screening, to molecular biology, cell biology, and imaging.

 

A complete description of research in Dr. Tucker’s lab can be found here: Tucker Lab webpage

Current Lab Members 

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
LiuQi PhDPostdoctoral Fellow
JessicaSpiltoirIBSGraduate Student

 

Past Trainees 

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
JoseMiranda PhDPostdoctoral Fellow
GopalPathakP.PhDPostdoctoral Fellow
AmirTaslimi PhDPostdoctoral Fellow
JustinVrana BSProfessional Research Assistant