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Department of Pharmacology

Department of Pharmacology

Paula Hoffman, PhD


Contact Information:

University of Colorado Denver
Department of Pharmacology
Mail Stop 8303, RC1-North
12800 East 19th Ave
Aurora CO 80045

Phone: (303) 724-3628
Fax: (303) 724-3663
Office: RC1-North, P18-6119

curriculum vitae

Affiliated Programs



The research in our laboratory focuses on the neuropharmacology of drugs of abuse, particularly alcohol (ethanol), including mechanisms of neuroadaptation (tolerance and dependence), neuronal toxicity, and craving or preference for alcohol.  We use a global, systems-based approach which uses genomic (RNA-Seq and microarray analysis of gene expression) and genetic techniques, as well as bioinformatic analyses, to identify candidate genes that may contribute to complex alcohol-related and other CNS-relevant traits, including alcohol tolerance and preference.  We use RNAi-based technologies for in vivo modulation of the expression of the candidate genes in particular brain areas and we evaluate the behavioral consequences of this modulation.  Overall, biochemical, molecular biological, genetic/genomic and behavioral techniques characterize our research.

Current Lab Members

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePosition
SeijaTillanenI.BSSenior Professional Research Assistant

Former Trainees

 Results From Personnel : Selected site and subsites
First NameLast NameMiddle InitialDegreePositionLab Name
PeterClappA.PhDPostdoctoral FellowHoffman
DanielaHartsternP.PhDPostdoctoral FellowHoffman