Education and Traning:- Postdoctoral
Research, Women’s Cancer Research Center – University of Pittsburgh Cancer
Institute, Pittsburgh, PA (2011-2016)
- Ph.D., Pharmacology, 2011 – University of Michigan,
Ann Arbor, MI (2006-2011)
- B.S., Genetics and Molecular Biology – University of
Michigan, Ann Arbor, MI (2002-2006)
Research Interests:
Mechanisms of estrogen receptor (ER) signaling in breast cancer, with a focus on invasive lobular carcinoma (ILC)
Mechanisms of resistance to endocrine therapies (ie anti-estrogen drugs)
Hormone receptor signaling and transcriptomics during endocrine therapy and the development of resistance to endocrine therapy
Development of new therapeutic strategies for breast cancer
Selected Publications:
For full listings, see https://www.researchgate.net/profile/Matthew_Sikora
or search ‘Sikora MJ’ on Pubmed; further discussion and explanation of our work
can be found at https://growkudos.com/profiles/106999
- Sikora,
M.J.,
et al. WNT4 mediates estrogen receptor
signaling and endocrine resistance in invasive lobular carcinoma cells. In
revision, Breast Cancer Research.
- Sikora,
M.J.,
et al. Endocrine response phenotypes
are altered by charcoal-stripped serum variability. Endocrinology. 2016 Jul
26:en20161297. [Epub ahead of print] PubMed PMID: 27459541.
- Sikora,
M.J.,
et al. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated
gene expression patterns and altered tamoxifen response. Cancer Res.
2014;74:1463–74. PMID: 24425047. PMCID: PMC3955299.
- Sikora,
M.J.,
et al. Invasive lobular carcinoma of the breast: patient response to systemic
endocrine therapy and hormone response in model systems. Steroids. 2013
Jun;78(6):568-75. PMID: 23178159.
- Sikora,
M.J.,
et al. Mechanisms of estrogen-independent breast cancer growth driven by low
estrogen concentrations are unique versus complete estrogen deprivation. Breast
Cancer Res Treat. 2012;134:1027–39. PMID: 22456984. PMCID: PMC3951731.
- Sikora,
M.J.,
et al. The Androgen Metabolite 5α-androstane-3β,17β-diol (3βAdiol) Induces
Breast Cancer Growth via Estrogen Receptor: Implications for Aromatase
Therapy. Breast Cancer Res Treat. 2009
May;115(2):289-96. PMID: 18521740. PMCID: PMC2728015.
Contacts:
Email: matthew.sikora@ucdenver.edu
Phone: 303-724-4301
Twitter: @mjsikora
Office location: Univ. of Colorado Denver | Anschutz Medical Campus
Research Center 1 South, Room 5117 |
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