Education and Traning:
Research, Women’s Cancer Research Center – University of Pittsburgh Cancer
Institute, Pittsburgh, PA (2011-2016)
- Ph.D., Pharmacology, 2011 – University of Michigan,
Ann Arbor, MI (2006-2011)
- B.S., Genetics and Molecular Biology – University of
Michigan, Ann Arbor, MI (2002-2006)
Mechanisms of estrogen receptor (ER) signaling in breast cancer, with a focus on invasive lobular carcinoma (ILC)
Mechanisms of resistance to endocrine therapies (ie anti-estrogen drugs)
Hormone receptor signaling and transcriptomics during endocrine therapy and the development of resistance to endocrine therapy
Development of new therapeutic strategies for breast cancer
For full listings, see https://www.researchgate.net/profile/Matthew_Sikora
or search ‘Sikora MJ’ on Pubmed; further discussion and explanation of our work
can be found at https://growkudos.com/profiles/106999
- Sikora, M.J. Family Matters: Collaboration and Conflict Among the Steroid Receptors Raises a Need for Group Therapy. Endocrinology. 2016 Dec;157(12):4553-4560. Review. PubMed PMID: 27835038; PubMed Central PMCID: PMC5133350.
et al. WNT4 mediates estrogen receptor
signaling and endocrine resistance in invasive lobular carcinoma cells. In
revision, Breast Cancer Research.
et al. Endocrine response phenotypes
are altered by charcoal-stripped serum variability. Endocrinology. 2016 Jul
26:en20161297. [Epub ahead of print] PubMed PMID: 27459541.
et al. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated
gene expression patterns and altered tamoxifen response. Cancer Res.
2014;74:1463–74. PMID: 24425047. PMCID: PMC3955299.
et al. Invasive lobular carcinoma of the breast: patient response to systemic
endocrine therapy and hormone response in model systems. Steroids. 2013
Jun;78(6):568-75. PMID: 23178159.
et al. Mechanisms of estrogen-independent breast cancer growth driven by low
estrogen concentrations are unique versus complete estrogen deprivation. Breast
Cancer Res Treat. 2012;134:1027–39. PMID: 22456984. PMCID: PMC3951731.
et al. The Androgen Metabolite 5α-androstane-3β,17β-diol (3βAdiol) Induces
Breast Cancer Growth via Estrogen Receptor: Implications for Aromatase
Therapy. Breast Cancer Res Treat. 2009
May;115(2):289-96. PMID: 18521740. PMCID: PMC2728015.
Office location: Univ. of Colorado Denver | Anschutz Medical Campus
Research Center 1 South, Room 5117