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Department of Orthopedics

Department of Orthopedics
 

Payne Regenerative Orthopedics Laboratory

Harnessing the potential of stem cells


Karin Payne, PhD
Karin Payne, PhD
Lab Director: Karin Payne, PhD

Research taking place in the Regenerative Orthopedics Laboratory focuses on harnessing the regenerative potential of stem cells for bone and articular cartilage tissue engineering.

We are particularly interested in optimizing and controlling the osteogenic and chondrogenic differentiation of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) by using different growth factors, scaffolds, and physicochemical cues.

Our long-term goal is to translate these research efforts into the clinic to enhance bone fracture repair, improve spine fusion, and treat articular cartilage defects early.

In the area of pediatric orthopedics, we have a collaborative research project on growth plate tissue engineering. ​​

Lee HH, O’Malley MJ, Friel NA, Payne KA, Qiao C, Xiao X, Chu CR. Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints. Hum Gene Ther, 2013;24(4):457-466. PMID: 23496155

Payne KA, Lee HH, Haleem AM, Martins C, Yuan Z, Qiao C, Xiao X, Chu CR. Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees. Osteoarthritis and Cartilage, 2011; 19(8):1058-1065. PMID: 21571082

Payne KA, Meszaros LB, Phillippi JA, Huard J. Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases ½, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells. Tissue Eng Part A, 2010; 16(12):3647-3655. PMID: 20617875

Payne KA, Didiano DM, Chu CR. Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells. Osteoarthritis and Cartilage, 2010; 18(5):705-713. PMID: 20171308

Tan H, Chu CR, Payne KA, Marra KG. Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials, 2009; 30(13):2499-2506. PMID: 19167750

​Li G, Corsi-Payne K, Zheng B, Usas A, Peng H, Huard J. The dose of growth factors influences the synergistic effect of vascular endothelial growth factor on bone morphogenetic protein 4-induced ectopic bone formation. Tissue Eng Part A, 2009; 15(8):2123-2133. PMID: 19215221

​Kubo S, Cooper GM, Matsumoto T, Phillippi JA, Corsi KA, Usas A, Li G, Fu FH, Huard J. Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells. Arthritis Rheum., 2009; 60(1):155-165. PMID: 19116905

​Matsumoto T, Kubo S, Meszaros LB, Corsi KA, Cooper GM, Li G, Usas A, Osawa A, Fu FH, Huard J. The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair. Arthritis Rheum., 2008; 58(12):3809-3819. PMID: 19035511

​Deasy BM, Corsi KA, Huard J. [The sex of muscle stem cells: must it be taken into account?]. Med Sci (Paris), 2007; 23(10):798-800. French. PMID: 17937884 

​Corsi KA, Pollett JB, Phillippi JA, Usas A, Li G, Huard J. Osteogenic potential of postnatal skeletal muscle-derived stem cells is influenced by donor sex. J Bone Miner Res., 2007; 22(10):1592-1602. PMID: 17605633

​Corsi KA, Schwarz EM, Mooney DJ, Huard J. Regenerative medicine in orthopaedic surgery. J Orthop Res., 2007; 25(10):1261-1268. PMID: 17551972 

​Pollett JB, Corsi KA, Weiss KR, Cooper GM, Barry DA, Gharaibeh B, Huard J. Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Stem Cells, 2007; 25(9):2302-2311. PMID: 17569791

​Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T, Cummins J, Fu FH, Huard J. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum., 2006; 54(2):433-442. PMID: 16447218

​Li GH, Peng H, Corsi K, Usas A, Olshanski A, Huard J. Differential effect of BMP4 on NIH/3T3 and C2C12 cells: implications for endochondral bone formation. J Bone Miner Res., 2005; 20(9):1611-1623. PMID: 16059633

​Corsi K, Li GH, Peng H, Huard J. Muscle-based gene therapy and tissue engineering for cartilage and bone healing. Current Genomics, 2004; 5(1):7-17.

​Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E, Fernandes JC. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur. J. Pharm. Biopharm., 2004; 57(1):1-8. PMID: 14729076

​Corsi K, Chellat F, Yahia L, Fernandes JC. Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials, 2003; 24(7):1255-1264. PMID: 12527266

Demers C, Hamdy RC, Corsi K, Chellat F, Tabrizian M, Yahia L’H. Natural coral exoskeleton as a bone graft substitute: a review. Biomed. Mater. Eng., 2002; 12(1):15-35. PMID: 11847406​ 

Director

Karin Payne, PhD

Assistant Professor
Department of Orthopedics
karin.payne@uc​denver.edu

CU Orthopedics
Research Complex 1 North, Room 2102
Aurora, CO 80045

BS, McGill University, Physiology
MS, Ecole Polytechnique de Montreal, University of Montreal, Biomedical Engineering, 2002
PhD, University of Pittsburgh, Bioengineering, 2007

Professional Research Assistant

Michelle Sauque

Bioengineering Graduate Student

Karl Treadwell

Medical Students

Brian Davis

Gabrielle Whitmore

Nicole Shaw