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Omid Masihzadeh, Ph.D.

Assistant Research Professor

Omid Masihzadeh, Ph.D.

Dr. Masihzadeh’s research has been focused towards two main subjects, laser assisted multiphoton microscopy, and development of laser assisted surgical tools. Functional and structural multiphoton imaging, including second harmonic generation (SHG), third harmonic generation (THG), two-photon autofluorescent (2PAF), Raman spectroscopy, and coherent anti-Stokes Raman spectroscopy, has found increasing interest in the laboratory-based research. Properties like subcellular resolution, along with the ability to obtain structural imaging make these modalities unique compared to linear imaging modalities. Dr. Masihzadeh’s goal is on optimizing these tools for ocular specific research.

Femtosecond lasers, the centerpiece in multiphoton microscopy, have been recently introduced as an important tool to assist in performing ocular surgeries. The currently available cataract surgery femtosecond lasers help with creating corneal incisions, incising the anterior capsule of the lens and partially fragmenting the lens. It has become clear however that there are performance limitations inherent to the hardware used in these devices. Further development of femtosecond ocular surgery hardware is another goal in Dr. Masihzadeh’s research.

  1. O. Masihzadeh, D. Ammar, M. Y. Kahook, E. Gibson, T.C. Lei, “Direct trabecular meshwork imaging in porcine eyes through multiphoton gonioscopy” (under review)(2012)
  2. O. Masihzadeh, T.C. Lei, D. Ammar, E. Gibson, M.Y. Kahook, “A multiphoton microscope platform for imaging the mouse eye”, Mol. Vis. 18 (2012)
  3. T.C. Lei, D. Ammar, O. Masihzadeh, E. Gibson, M.Y. Kahook, “Label-free imaging of trabecular meshwork cells using Coherent Anti-Stokes Raman Scattering (CARS) microscopy”, Mol. Vis. (2011)
  4. O. Masihzadeh, D. Ammar, T.C. Lei, E.Gibson, M.Y. Kahook, “Real-time measurement of nicotinamide adenine dinucleotide in live human trabecular meshwork cells: Effect of acute oxidative stress”, Exp Eye Res (2011)
  5. D. A. Ammar, T. C. Lei, O. Masihzadeh, E. A. Gibson, and M. Y. Kahook, “Trans-Scleral Imaging of Human Trabecular Meshwork by Two-Photon Microscopy”, Journal of Ophthalmology (2011)
  6. E. A. Gibson, O. Masihzadeh, T. C. Lei, D. A. Ammar and M. Y. Kahook, “Multi-photon microscopy for ophthalmic imaging”, Journal of Ophthalmology (2010)  
  7. O. Masihzadeh, P. Schlup and R.A Bartels, “Label-free second harmonic generation holographic microscopy of biological specimens.”, Opt. Express 18 , 9840-9851 (2010)
  8. E. A. Gibson, O. Masihzadeh, T. C. Lei, D. A. Ammar, M. Y. Kahook, “Multi-photon microscopy for ophthalmic imaging”,J. Ophthalmology, (2010)
  9. D. Kupka, J. Wilson, O. Masihzadeh, R.A Bartels, “Distinguishing bulk and interface modulation of optical third harmonic generation due to coherent optical phonon excitation Corresponding”, Chem. Phys. Lett. 490 , 97-101 (2010)
  10. L. Xu, P. Schlup, O. Masihzadeh, R.A. Bartels, R. Tribino, “ Analysis of the measurement of polarization- shaped ultrashort laser pulses by tomographic ultrafast retrieval of transverse light E-fields (TURTLE)”, J. Opt. Soc. Am. B , 26, 2363-2369 (2009)
  11. O. Masihzadeh, P. Schlup and R.A Bartels “Enhanced spatial resolution in third-harmonic microscopy through polarization switching”, Opt. Lett. 34 , 1240-1242 (2009)
  12. O. Masihzadeh, P. Schlup and R.A Bartels “Control and measurement of spatially inhomogeneous polarization distributions in third-harmonic generation microscopy”, Opt. Lett. 34 , 1090-1092 (2009).
  13. P. Schlup, O. Masihzadeh, and R.A Bartels “Tomographic retrieval of the polarization state of an ultrafast laser pulse.”, Opt. Lett. 33 , 267-269 (2008)
  14. O. Masihzadeh, P. Schlup and R.A Bartels “Complete polarization state control of ultrafast laser pulses with a single linear spatial light modulator.”, Opt. Express 15 , 18025-18032 (2007)