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Purkinje cell plasticity


Purkinje cells in the cerebellum are sensitive to global ischemia and ion channel dysfunction in these neurons may contribute to motor coordination deficits observed after a cardiac arrest.  Current projects in the lab are focused on the contribution of NMDA receptors to synaptic plasticity and Purkinje cell damage after cardiac arrest. This project uses a combination of electrophysiology, neurobehavior, immunohistochemistry and quantitative RT-PCR to investigate changes in synaptic transmission, receptor expression and motor coordination.