Dr. Fabrice Dabertrand
Primary Appointment: Assistant Professor, Anesthesiology
- BS Structural Biochemistry, University of Bordeaux Segalen, France
- B.S. Cell Biology and Physiology, University of Bordeaux Segalen, France
- Ph.D. Neuroscience and Neuropharmacology, University of Bordeaux Segalen, France
- Postdoctoral Fellow, Center for Cognitive and Integrative Neurosciences, University of Bordeaux Segalen, France
- Postdoctoral Fellow, Pharmacology, Larner College of Medicine University of Vermont, VT
- Assistant Professor, Pharmacology, Larner College of Medicine University of Vermont, VT
Mail Stop B112
12700 E. 19th Avenue, room P15-7590A
Aurora, Colorado 80045
Telephone: (303) 724-3792
The overall goal of our laboratory is to understand the control of cerebral blood flow by ion channels and calcium signaling in the pericytes, endothelial cells, and smooth muscle cells that constitute the parenchymal microcirculation, and use this information to combat brain diseases with a vascular component.
The overall goal of our research is to understand the control of cerebral blood flow in physiological and small vessels disease conditions, with a special interest in the interaction between neural activity and the intracerebral microvasculature. Our early studies focused on the control of smooth muscle and endothelial cell function by ion channels, providing some of the first measurements of membrane potential, calcium signaling, and diameter imaging of mouse pressurized parenchymal arterioles. In our more recent work on neurovascular coupling, the mechanism sustaining functional hyperemia, we established brain capillaries as an active sensory web detecting neural activity and communicating it to upstream arterioles in the form of vasodilatory signals to match the local metabolic demands. Developing these approaches in murine microcirculation was a tour de force that lets us to use genetic mouse models and investigate potential treatments for brain diseases with a vascular component.
Click here for Dr. Fabrice Dabertrand's publications on NCBI