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University of Colorado School of Medicine
 

Pharmacology

Tom French, PhD


Q: Doesn't grapefruit inhibit p450?
A: I have heard that there is a compound in grapefruit that occupies the active site and inhibits its efficacy.

Q: How does aspirin prevent heart attacks? What kind of drugs, if any, are stored indefinitely in the body?
A: Can you eventually reach the toxic level? I have heard of this phenomenon with chemicals like monomeric poly-acrylamide.

Q: What is the difference between Naproxen and Ibuprofen? And which is the best anti-inflammatory?
A: Rather than try to give you a quick answer, because this is a question on which a lot might ride, please look at Consumers Reports discussion of these two drugs: http://www.consumerreports.org/health/best-buy-drugs/nsaids.htm​

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