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University of Colorado Cancer Center

University of Colorado Cancer Center, A National Cancer Institute-designated Comprehensive Cancer Center

Genomics Shared Resource

The Genomics Shared Resource provides consultation and service for advanced, state-of-the-art microarray and Next Generation (NextGen) DNA sequencing technology for translational cancer research. The GSR’s comprehensive genomics research capacity, including expression, exon, tiling, re-sequencing and SNP/CNV arrays for studying gene expression/regulation changes, genotyping, and copy number variation is one of the most heavily used CU Cancer Center research resources, having supported nearly 350 investigators to date.

GSR was established in response to the technological advances in gene array, as well as the demand for high throughput expression analysis and genomic investigation to investigate pathogenesis, therapeutics, genetic susceptibility and gene discovery in cancer research. The informatics aspect is of paramount importance, and five distinct analysis programs, as well as a network, are used to store, share and analyze the data.

The Genomics Shared Resource is comprised of:

  • The Microarray Service
  • The quantitative PCR Service
  • Our Objectives:

  • Analyze genetic function and variation using both pre-made and custom designed oligonucleotide arrays.
  • Facilitate gene discovery.
  • Accurately quantitate gene expression using real time PCR and GenomeLab GeXP technology.
  • Support for data analysis and bioinformatics by providing member access to our data mining tools.
  • Provide consultation and educational services to help those members with limited knowledge on genomics technology and to bring the shared resource customers up to date as technology advances.