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Karin A. Payne, Ph.D.

Assistant Professor


Program and Departmental Associations:

Department of Orthopaedics

Director: University of Colorado Cancer Center Flow Cytometry Core

Graduate School and Center Affiliations:

      Associate Professor, Integrated Department of Immunology
      Member, University of Colorado Cancer Center

Education:

      Ph.D., Colorado State University, 1987

Postdoctoral Training:

      NSF Postdoctoral Fellowship, University of California, Berkeley, 1987-1990
      NIH Postdoctoral Fellowship, University of California, Berkeley, 1990-1993


The goal of the Regenerative Orthopaedics Laboratory is to develop novel stem cell-based therapies for musculoskeletal tissue engineering. The current focus is on the therapeutic potential of bone marrow stem cells and induced pluripotent stem cells.


Recent Publications

    • Yingzhu Li, Nancy Clough, Xiaolin Sun, Weidong Yu, Brian L. Abbott, Christopher J. Hogan1, andZonghan Dai. Bcr-Abl induces abnormal cytoskeleton remodeling, 1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway. J. Cell Sci. 120: 1436-1446. 2007.
    • Li, F.X., Zhu, J.W., Tessem, J.S., Beilke, J., Varella-Garcia, M., Jensen, J., Hogan, C.J., DeGregori, J. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc. Nat. Acad. Sci. (USA) 100: 12935-12940. 2003.
    • Li, F.X., J.Z. Zhu, C.J. Hogan and J. DeGregori. Defective gene expression, S phase progression and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol. Cell. Biol. 23: 3607-3622. 2003.
    • Lacaud, G., Gore, L., Kennedy, M., Kouskoff, V., Palis, J., Kingsley, P., Speck, N., Hogan, C.J., Carlsson, L., Keller, G. Runx1 is required for hemangioblast development. Blood 100: 458-466. 2002
    • Hogan, C.J., Shpall, E.J., Keller, G. Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice. Proc. Nat. Acad. Sci. (USA) 99: 413-418. 2002.
    • Shpall, E.J., Quinones, R., giller, R., Zeng, C., Baron, A.E., Jones, R.B., Bearman, S.I., Nieto, Y., Freed, B., Madinger, N., Hogan, C.J., Slat-Vasquez, V., Russell, P., Blunk, B., Schissel, D., Hild, E., Malcolm, J., Ward, W., McNiece, I.K. Transplantation of ex-vivo expanded cord blood. Biol. Blood Marrow Transplant 8: 368-376. 2002.
    • Varella-Garcia, M., Hogan, C.J., Odom, L.F., Murata-Collins, J.L., Ai, H., Chen, L., fichkind, K., Paskulin, G., Andreeff, M., Brizard, A., McGavran, L., Gemmill, R.M., Berger, R., Drabkin, H.A. Minimal residual desease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting. Leukemia 15: 1408-1414. 2001.
    • McNiece, I., Jones, R., Bearman, S., Cagnoni, P., Nieto, Y., Franklin, W., Ryder, J., Steele, A., Stoltz, J., Hartsough, K., Russell, P., McDermitt, J., Hogan, C.J., Murphy, J., Shpall, E.J. Ex vivo expanded peripheral blood progenitor cells provide rapid neutrophil recovery in breast cancer patients following high dose chemotherapy. Blood 96: 3001-3007. 2000.
    • Hogan, C.J., Shpall, E.J., McNiece, I., Keller, G. Multilineage engraftment in NOD/LtSz-scid/scid mice from mobilized human CD34+ peripheral blood progenitor cells. Biol. Blood and Marrow Transpl. 3: 236-246. 1997.
    • Hogan, C.J., Shpall, E.J., McNulty, O., McNiece, I., Dick, J.E., Shultz, L.D., Keller, G. Engraftment and development of human CD34+-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood 90: 85-96. 1997.