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Welcome to the Barbara Davis Center for Diabetes at the University of Colorado School of Medicine on the Anschutz Medical Campus in Aurora, Colorado.

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Type 1 Diabetes: Cellular, Molecular & Clinical Immunology

Edited by George S. Eisenbarth, Online Edition Version 3.0

This online edition is updated frequently. To receive email notifications of chapter and slideset revisions, please register here.

For comments, corrections or to contribute teaching slides please contact Dr. George Eisenbarth at:


Type 1 Diabetes: Cellular, Molecular & Clinical Immunology Edited by George Eisenbarth
1. Primer Immunology and Autoimmunity - Updated 9/2011
Stephanie C. Eisenbarth and Dirk Homann
Chapter 1 Powerpoint slide set - Updated 6/2012

2. The Pancreatic Beta-Cell - Updated 3/2012
Suparna A., George S. Eisenbarth, update of 2002 chapter by Kirstine Juhl and John Hutton

A. Cell Therapy of Diabetes Powerpoint slide set - Updated 7/2006
B. Proprotein Processing and Pancreatic Islet Function Powerpoint slide set - Updated 1/2012
C. Stimulus-Secretion Coupling in the Pancreatic Beta-Cell Powerpoint slide set - Updated 4/2009

Human Pancreas Development
Suparna A. Sarkar MBBS, PhD 3/2012
3. Animal Models of Type 1 Diabetes: Genetics and Immunological Function - Updated 4/2011
George S. Eisenbarth
Chapter 3 Powerpoint slide set - Udated 6/2012
4. The Role of T Cells in Beta Cell Damage in NOD Mice and Humans - Updated 10/2011 Edwin Liu, George S. Eisenbarth, and Howard Davidson Chapter 4 Powerpoint slide set (T Cells) - Updated 6/2012
Chapter 4 Powerpoint slide set - Updated 3/2010
5. Type 1 Diabetes Mellitus: An Inflammatory Disease Of The Islet - Updated 3/2006
Regine Bergholdt, Peter Heding, Sif Groth Rønn, Joachim Størling, Morten Tonnesen, Flemming Pociot, and Thomas Mandrup-Poulsen. Steno Diabetes Center, Gentofte, Denmark
Chapter 5 Powerpoint slide set - Updated 3/2002
6. The Immunobiology of Pancreatic Islet Transplantation Powerpoint Slide Set - Updated 4/2006
Marilyne Coulombe and Ronald G. Gill
Chapter 6 Powerpoint slide set - Updated 4/2006
7. Type I Diabetes Mellitus of Man: Genetic Susceptibility and Resistance - Updated 10/2012
Andrea K. Steck, Alberto Pugliese, and George S. Eisenbarth
Chapter 7 Powerpoint slide set - Updated 9/2009
Additional Slideset: Chapter7_Sardinia.ppt
Additional Slideset: Chapter7_Japan.ppt
8. Autoimmune Polyendocrine Syndromes - Updated 9/2012
nnifer M. Barker and George S. Eisenbarth
Chapter 8 Powerpoint slide set - Updated 6/2012
9. Epidemiology of Type I Diabetes - Updated 11/2010
Marian Rewers, MD, PhD, Jill Norris, PhD, Adam Kretowski, MD, PhD
Chapter 9 Powerpoint slide set - Updated 9/2011
Additional Slideset: Chapter9_Sardinia.ppt
10. Humoral Autoimmunity - Updated 9/2012
Liping Yu and George S. Eisenbarth
Chapter 10 Powerpoint slide set - Updated 8/2012
11. Prediction of Type IA Diabetes: The Natural History of the Prediabetic Period - Updated 9/2012
orge S. Eisenbarth
Chapter 11 Powerpoint slide set - Updated 8/2012
12. Clinical Trials for the Prevention of Type I Diabetes - Updated 6/2009
Peter Chase, Peter Gottlieb, & George S. Eisenbarth
Chapter 12 Powerpoint slide set - Updated 6/2012
Mark Pescovitz Immunotherapy Review 2008 Slideset (added 6/2008)
ADA Update June 2008.ppt Powerpoint slide set (added 7/2008)
13. Theoretical Essays
Kevin J. Lafferty and George S. Eisenbarth, Editors
A. The Development of Autoimmune Diabetes
Kevin J. Lafferty
B. Pathogenesis of Type I Diabetes
George S. Eisenbarth
C. The New Math of Diabetes: When Th1 - Th2 = Th0
Donald Bellgrau and David P. Gold
D. Why Doesn't Everyone Develop Autoimmune Diabetes?
David W. Talmage and Richard J. Sanderson
E. Can Getting Excited Over Nothing Provoke Autoimmunity?
Don Bellgrau
F. Pathogenesis of Type 1 Diabetes - A Viewpoint
Matthias G. von Herrath
G. Was There Type 1 Diabetes in the Olduvai Gorge?
David V. Serreze and Derry C. Roopenian
Chapter 13B: Pathogenesis of Type 1 Diabetes Powerpoint slide set
Appendix: Selected Type 1A Diabetes Resources - Updated 4/2008
George S. Eisenbarth