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Michael A. Henry

Professor, Associate Dean for Academic Affairs


​Department of Surgical Dentistry
Mail Stop F831
13065 E. 17th Avenue
Aurora, CO 80045

Phone: 303-724-9608
Fax: 303-724-7109
Email: michael.henry@ucdenver.edu

Education:

  • PhD in Biological Structure, University of Washington School of Medicine
  • Certificate in Facial Pain, University of Florida, College of Dentistry
  • DDS, University of Washington School of Dentistry
  • BS in Zoology, Washington State University

Honors and Awards:

  • Outstanding Didactic Instructor, University of Colorado Dental Hygiene Class of 2003
  • American Board of Orofacial Pain- Diplomate 1999
  • Omicron Kappa Upsilon, University of Colorado School of Dentistry, 1997
  • Outstanding Basic Science Instructor, University of Colorado Dental Hygiene Class of 1996
  • Senior Postdoctoral Research Fellow, Department of Neurological Surgery, University of Washington School of Medicine, 1992
  • Individual Physician Scientist Award for Dentists, NIDR, 1987-1992
  • Sigma Xi, University of Florida School of Dentistry, 1986
  • Postdoctoral Research Fellow and Clinical Neuroscience Trainee, Department of  Neurological Surgery, University of Washington School of Medicine, 1983-1985, Washington School of Medicine, 1992
  • Mosby Scholarship Award, University of Washington School of Dentistry, 1983
  • Phi Beta Kappa, Washington State University, 1978
  • Graduated Cum Laude, Washington State University, 1978

Department Affiliations:

  • Department of Surgical Dentistry - Division of Oral & Maxillofacial Surgery

Research Interests:

  • The normal organization of the trigeminal brainstem nuclear complex and its response and reorganization following injury with emphasis on central nervous system plasticity.
  • Neuroanatomical basis for pain transmission and modulation within the trigeminal nucleus.
  • The correlation of basic research findings with the pathophysiology of orofacial pain patients and the development of new treatments for these patients.
  • Sodium channel localization within the normal and injured rat trigeminal system; contribution to neuropathic pain states.
  • Sodium channel and thermoreceptor localization within normal and diseased human teeth.
  • Human trigeminal pulpal pain mechanisms.
  • Regeneration of the human dental pulp with post-natal, dentally-derived stem cells.
  • Glial-neuro-immune-vascular interactions in neuropathic and inflammatory trigeminal pain states.
  • Mechanisms of oral cancer pain.
  • Post-surgical pain mechanisms.

Recent Publications:

  • Chrepa V.V., Henry M.A., Diogenes, A.  Delivery of apical mesenchymal stem cells into root canals of mature teeth. Journal of Dental Research, 94:1653-1659, 2015.
  • Henry M.A., Fairchild D.D., Patil M.J., Hanania T., Hain H.S., Davis S.F., Malekiani S.A., Hu A., Sucholeiki R., Nix D. and Sucholeiki I. Effect of a novel, orally active matrix metalloproteinease-2 and-9 inhibitor in spinal and trigeminal rat models of neuropathic pain. Journal of Oral and Facial Pain and Headache, 29(3):286-296, 2015.
  • de Almeida J.F.A., Chen P., Henry M.A. and Diogenes A.  Stem cells of the apical papilla regulate trigeminal neurite outgrowth and targeting through a BDNF-dependent mechanism. Tissue Engineering Part A, 20:3089-3100, 2014.
  • Rowan M.P., Szteyn K., Doyle A.P., Gomez R., Henry M.A. and Jeske NA.  Beta-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons. Molecular Pain, 10:50, 2014.
  • Patil, M.J., Henry M.A. and Akopian A.N. Prolactin receptor regulation of neuronal excitability and channels.  Channels, 8:193-202, 2014.
  • Gonzales C.B., Kirma N., De La Chap J., Chen R., Henry  M.A., Luo S. and Hargreaves K.M.  Vanilloids induce oral cancer apoptosis independent of TRPV1 interactions.  Oral Oncology, 50:437-447, 2014.
  • Martin D., de Almeida J.F.A., Henry M.A., Khaing Z.K., Schmidt C.E., Teixeira F.B. and Diogenes A. Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla (SCAP) survival and differentiation.  Journal of Endodontics, 40:51-54, 2014.
  • Belugin S., Diogenes A., Patil M.J., Ginsburg E., Henry M.A. and Akopian A.N. Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons.  Journal of Biological Chemistry, 288:34943-34955, 2013.
  • Patil M.J., Ruparel S.B., Henry M.A. and  Akopian A.N.  Prolactin regulates TRPV1, TRPA1 and TRPM8 in sensory neurons in sex-dependent manner: contribution of prolactin receptor to inflammatory pain.  American Journal of Physiology - Endocrinology and Metabolism, 305:E1154-E1164, 2013.
  • Patil M., Green D.P., Henry M.A. and Akopian A.N.  Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice.  Neuroscience, 253:132-141, 2013.
  • Ruparel S., Hargreaves K.M., Eskander M., Rowan S., deAlmeida, J.F.A., Roman L. and Henry M.A. The oxidized linoleic acid metabolite-cytochrome p450 system is active in biopsies from patients with inflammatory dental pain. Pain, 154:2363-2371, 2013.
  • Green D.P., Ruparel S., Roman L., Henry M.A. and Hargreaves K.M. Role of endogenous TRPV1 agonists in a post-burn pain model of partial-thickness injury. Pain, 154:2512-2520, 2013.
  • Diogenes A., Henry M.A., Teixeira F.B. and Hargreaves K.M. An update on clinical regenerative endodontics.  Endodontics Topics, 28:2-23, 2013.
  • Ruparel N.B., de Almeida J.F.A.., Henry M.A. and Diogenes A.  Characterization of a stem cell of apical papilla (SCAP) cell line: effect of passage on cellular phenotype.  Journal of Endodontics, 39:357-363, 2013.
  • Loyd D.R., Henry M.A. and Hargreaves K.M.  Serotonergic neuromodulation of peripheral nociceptors.  Seminars in Cell and Developmental Biology, 24:51-57, 2013.
  • Levinson S.R., Luo S. and Henry M.A.  The role of sodium channels in chronic pain.  Muscle and Nerve, 46:155-165, 2012.
    Ruparel S., Henry M.A., Akopian A., Patil M., Zeldin D.C., Roman L. and Hargreaves K.M.  Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.  Pain. 153:2031-2039, 2012.
  • Henry M.A., Luo S., and Levinson S.R.  Unmyelinated nerve fibers in the human dental pulp express markers for myelinated fibers and show sodium channel accumulations. BMC Neurosci. 13:29, 2012.

Selected Publications:

  • Loyd D.R., Weiss G., Henry M.A. and Hargreaves K.M.  Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain, 152(10):2267-2276, 2011.
  • Trevino E.N., Patwardhan A.N., Henry M.A., Perry G.M., Dybal-Hargreaves N., Hargreaves K.M. and Diogenes A. Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet rich plasma scaffold in human root tips.  Journal of Endodontics, 37(8):1109-1115, 2011.
  • Diogenes A., Ferraz C.C.R., Akopian A.N., Henry M.A. and Hargreaves K.M.  LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons.  Journal Dental Research, 90(6):759-764, 2011.
  • Lovelace T.W., Henry M.A., Hargreaves K.M. and Diogenes A.  Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedures.  Journal of Endodontics, 37(2):133-138, 2011.
  • Luo S., Perry G.M., Levinson S.R. and Henry M.A.  Pulpitis increases the proportion of atypical nodes of Ranvier in human dental pulp axons without a change in Nav1.6 sodium channel expression.  Neuroscience, 169:1881-1887, 2010.
    Jeske N.A., Patwardhan A.M., Ruparel N.B., Akopian A.N., Shapiro M.S. and Henry M.A.  A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain, 146:301-307, 2009.
  • Henry M.A., Luo S., Foley B.D., Rzasa R.S., Johnson L.R. and Levinson S.R. Sodium channel expression and localization at demyelinated sites in painful human dental pulp. Journal of Pain, 10(7):750-758, 2009.
  • Hargreaves K.M., Geisler T., Henry M.A. and Wang Y.  Regeneration potential of the young permanent tooth: what does the future hold?  Journal of Endodontics, 34(7S): S51-56, 2008.
  • Luo S., Perry G.M., Levinson S.R. and Henry M.A.  Nav1.7 expression is increased in painful human dental pulp. Molecular Pain, 4:16, 2008.
  • Henry M.A. and Hargreaves K.M. Peripheral mechanisms of odontogenic pain. In: Dental Clinics of North America, Temporomandibular Disorders and Orofacial Pain, 51:19-44, 2007.
  • Henry M.A., Freking, A.R., Johnson, L.R. and Levinson S.R.  Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury. BMC Neuroscience, 8:56, 2007.
  • Henry M.A., Freking A.R., Johnson L.R. and Levinson S.R.  Increased sodium channel immunofluorescence at myelinated and demyelinated sites following an inflammatory and partial axotomy lesion of the rat infraorbital nerve. Pain, 124:222-233, 2006.
  • Henry M.A., Sorensen H.J., Johnson L.R. and Levinson S.R.  Localization of the Nav1.8 sodium channel isoform at nodes of Ranvier in normal human radicular tooth pulp.  Neurosci. Lett., 380 (1-2):32-36, 2005.
  • Savage M.G. and Henry M.A.  Preoperative nonsteroidal anti-inflammatory agents: review of the literature.  Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 98(2):146-152, 2004.
  • Granholm A.-C., Srivastava N., Mott J.L., Henry S., Henry M., Westphal H., Pichel J.G., Shen L. and Hoffer B.J.  Morphological alterations in the peripheral and central nervous systems of mice lacking GDNF: immunohistochemical studies.  J. Neurosci., 17:1168-1178, 1997.
  • Bowenkamp K.E., David D., Lapchak P.L., Henry M.A., Granholm A.C., Hoffer B.J. and Mahalik T.J.  6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat.  A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor.  Exp. Brain Res., 111:1-7, 1996.
  • Iliakis B., Anderson N.L., Irish P.S., Henry M.A. and Westrum L.E.  Electron microscopy of immunoreactivity patterns for glutamate and gamma-aminobutyric acid in synaptic glomeruli of the feline spinal trigeminal nucleus (subnucleus caudalis).  J. Comp. Neurol., 366:465-477, 1996.
  • Henry M.A., Johnson L.R., Nousek-Goebl N.A. and Westrum L.E.  Light microscopic localization of calcitonin gene-related peptide in the normal feline trigeminal system and following rhizotomy.  J. Comp. Neurol., 365:526-540, 1996.
  • Bowenkamp K.E., Hoffman A.F., Gerhardt G.A., Henry M.A., Biddle P.T., Hoffer B.J. and Granholm A.-Ch.  Glial cell-line derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons.  J. Comp. Neurol., 355:479-489, 1995.
  • Hudson J., Granholm A.-Ch., Gerhardt G.A., Henry M.A., Hoffman A., Biddle P., Leela N.S., Mackerlova L., Lile J.D., Collins F. and Hoffer B.J.  Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Res. Bull., 36:425-432, 1995.
  • Henry M. A., Westrum L. E., Bothwell M. and Press S.  Electron microscopic localization of nerve growth factor receptor (p75)-immunoreactivity in pars caudalis/medullary dorsal horn of the cat.  Brain Research, 642:137-145, 1994.
  • Henry M. A., Nousek-Goebl N. A. and Westrum L. E.  Light and electron microscopic localization of calcitonin gene-related peptide immunoreactivity in lamina II of the feline trigeminal pars caudalis/medullary dorsal horn: a qualitative study.  Synapse, 13:99-107, 1993.
  • Henry M. A., Westrum L. E. and Johnson L. R.  Enhanced ultrastructural visualization of the horseradish peroxidase-tetramethylbenzidine reaction product.  J. Histochem. Cytochem. 33(12):1256-1259,1985.
 

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