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Clinical Trials

Volunteer to Be Part of a Research Study

Page through all School of Medicine clinical and research trials below. There are two categories:

  • Detailed Trial Descriptions, submitted by researchers, includes trial specifics and contact information.

  • Additional Clinical Trials, which include basic study details. To contact the researcher either Google the PI (primary investigator) name or use our campus directory.

If you are a researcher seeking volunteers and your study is not posted, please
submit your Web ad here.

Detailed Trial Descriptions

 Results From Research and Clinical Trials : Selected site
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COMIRB Approved Advertisement TitleStudy GoalsEligibility CriteriaDate PostedCategory
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This study will study the effects of testosterone therapy on behavior, mood, problem solving, attention span, and motor skills in adolescent males with Klinefelter syndrome in early puberty. During this period in early puberty there is a lot of variability in how and when doctors start testosterone therapy. This study will evaluate if there are benefits to starting testosterone therapy in early puberty.
Participants with Klinefelter syndrome in early puberty (around age 10-15).
Volunteers with Alzheimer’s Disease Needed for Memory Study
To examine the safety and efficacy of the study drug, Sargramostim (Leukine®), on memory in adults with Mild-to-Moderate Alzheimer’s Disease.
1. Age 55 to 85 years; 2. Should have a mild-to-moderate Alzheimer's Disease diagnosis (Mini-Mental State Examination 10-26 inclusive); 3. If on anti-dementia treatment should be on stable treatment for at least 2 months (i.e. cholinesterase inhibitor and/or Memantine or Axona); 4. Stable on all other medications for at least 30 days prior to screen; 5. Should be fluent in English; 6. Should be physically able to participate by medical history, clinical exam and tests; 7. Should have a study partner to accompany them to scheduled visits.
T•A•C•I•T - Therapy After Cochlear Implants Using Telemedicine
This research plans to learn more about the use of telemedicine as a means of providing therapy to children who have a cochlear implant(s). While Auditory-Verbal Therapy has typically been delivered in person, many people are starting to access therapy over the internet. We are conducting this research to determine if the outcomes of therapy are the same when AVT is delivered in person and via telemedicine.
The TA•C•I•T team is looking for children ages 6 mos.-6 yrs. old who were implanted with cochlear implant(s) before age  3 ½..  Each child will spend nine months in both the in-person and telemedicine condition. The therapist will remain the same throughout the study. Total participation will last 18 months. The child will be tested three times: once when the study starts, and every nine months after that. A qualified study team member will administer speech, listening, and language tests to the child. They will also receive tests to identify how well their auditory area of the brain is developing.
Participants with Chronic Kidney Disease Needed for a Research Study about Phosphate
We are looking for men and women to participate in a research study examining whether lowering blood levels of phosphate will improve blood vessel function.
We need men and women who:  -are age 40-79 years old; women must be post-menopausal;  -have chronic kidney disease stage 3b or 4 (estimated GFR 15-45 ml/min);  -are not taking phosphate binders;  -do not have high blood phosphate (>5.5 mg/dL).
Volunteers Needed for Cardiovascular Research Study at the Division of Renal Diseases and Hypertension Clinical Research Unit
This research study will compare blood vessel function in healthy adults to adults with two different types of kidney disease. The testing visit will include non-invasive testing of blood vessel function and collection of blood and cells from an IV.  As a volunteer, you will receive the following information about your health: resting EKG; blood cholesterol screening,    blood sugar screening, blood pressure screening, and physical Exam.
We are looking for men and women, aged 50-80 years, non-smokers, generally healthy, and free from hypertension.  Women must not be pregnant of trying to become pregnant
8/22/2017--Select a Category--
Healthy Women Needed
This study plans to research how metabolic challenges of increased insulin and increased fats affect reproductive hormones.
In order to be eligible you must: Be a healthy woman age 18-38, have a BMI between 18 and 25, have regular menstrual cycles (25-35 days), not be currently using hormones (like birth control medication), not be pregnant or planning to become pregnant. In order to enroll all participants must meet specific criteria. The criteria listed above is only a partial list of all the requirements. Only a clinical research staff member can determine eligibility.
8/22/2017--Select a Category--
Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease?
This study plans to learn more about the effect of palliative care on patients and caregivers affected by Parkinson’s disease or related disorders including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA) or Lewy Body Dementia (LBD). Palliative care is a treatment approach focused on improving quality of life by relieving suffering in the areas of physical symptoms such as pain, psychiatric symptoms such as depression, psychosocial issues and spiritual needs.
Over the age of 40 and have been diagnosed with Parkinson's disease (PD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), or Lewy Body Dementia (LBD); and have unmet needs, such as poorly controlled non-motor symptoms, psychological issues, spiritual challenges or caregiver distress.
8/22/2017Nervous System Diseases
Volunteers Needed for a Research Study about Rheumatoid Arthritis
The purpose of this study is to learn more about how rheumatoid arthritis develops even before the first joint symptoms appear.
You may be able to participate in the study if: You are at least 18 years old You do NOT have rheumatoid arthritis (RA)
8/22/2017Immune System Diseases
Heart Sounds at Home: Prospective Maternal Surveillance of SSA Positive Pregnancies using a Hand-held Fetal Heart Rate Monitor
The purpose of the research study is for pregnant SSA positive mothers, using a home Doppler fetal heart rate monitor, to detect abnormal heart rates and rhythms in their babies before they are both
Exclusion criteria are: 1. If you are less than 16 weeks or > 18 6/7 th weeks pregnant 2. If you do not have SSA antibodies
8/22/2017Diseases and Abnormalities at or before Birth
Smokers Wanted for Brain Research Study
We want to know if magnetic stimulation of the brain can reduce cigarette cravings. We will do an MRI of your brain before and after the magnetic stimulation. This study takes 3 hours of your time in one single visit. We want to know if transcranial magnetic stimulation of the brain can reduce cigarette cravings. We will do an MRI of your brain before and after the magnetic stimulation. This study takes 3 hours of your time in one single visit. This study is funded by the NIH (F32 DA 041011).
You may qualify if you: • Smoke at least 10 cigarettes per day (on average) • Are 18-55 years old • Have no metal implants • Have no history of seizures • Are able to not smoke for 3 hours
8/22/2017Behaviors and Mental Disorders
We are testing the effect of two different exercise programs on glycemic control.
We are seeking men & women between the ages of 60-79 years old, who have elevated levels of blood glucose but are otherwise healthy.
8/22/2017Nutritional and Metabolic Diseases
Are you interested in learning about how your breast milk helps your baby grow?
To find out how maternal size and diabetes status affect her breast milk To find out what unique parts of breast milk may affect how infants grow. To learn how to ensure infants receive the best nutrition possible
Women 20-35 with type 1, type 2,or gestational diabetes who are at least 28 weeks into their pregnancy and planning on exclusively breastfeeding their infant for at least 4 months and delivering at University of Colorado Hospital.
Free Family Therapy for Youth with Mood Problems
Helping youth and their families understand and cope with mood swings, develop plans for preventing moods from getting worse, communicate more effectively and solve family problems
  • Youth between 9-17 who has recently had significant mood swings, has at least one parent with bipolar disorder and does not abuse alcohol or substances. 
  • Must agree not to participate in family therapy with another provider for the first year.
MS Volunteers Needed for Research Study
Looking to see if there is a cognitive improvement with the treatment of oral estriol as compared to oral placebo
We are looking for: • Women 18-50 years old • Diagnosed with definite relapsing-remitting, secondary-progressive multiple sclerosis or primary-progressive multiple sclerosis • MS disease duration of 15 years or less • On stable dose of standard MS treatment with Copaxone®, Betaseron® (or Extavia®), Rebif®,Avonex®, Gilenya®, Aubagio®, Tecfidera®, or no treatment ----You are not eligible for the study if you are pregnant, breast-feeding, smoke, or have other serious medical conditions.
Genital Herpes?
This study will look at the body's immune response (how the body fights infection) to the onset of genital herpes.  1-2 study visits for blood draws over the course of 3 months.
  • 18+ years of age
  • Have developed an outbreak of genital herpes within the last 10 days.
Healthy Males needed for a research study of drug levels in blood and hair.
This study plans to learn more about how tenofovir and emtricitabine (Truvada) build up in cells in blood and hair. Participation will include two 12 week dosing periods separated by a 12 week washout period (total duration is 36 weeks). Eligible participants will be given the supply of medications for the study.
  • Must be age 18 to 50 years
  • Must own smartphone
  • Subject has a minimum scalp hair length of 2 cm in the occipital region.
  • Have a low risk for HIV-1 infection
The Role of Gut Bacteria in the Development of Type 1 Diabetes.
The goal of the research is to better understand the role bacteria that live in the intestine in the development of type 1 diabetes
  • Patients diagnosed with type 1 diabetes in the last 6 months 
  • Subjects with islet autoantibodies 
  • Subjects who do not have islet antibodies and are first-degree relatives of patients with diabetes or subjects with islet antibodies
  • 1-45 years of age
Are you interested in participating in a research study to help us learn more about where the fat tissue in your body originates?
To understand if some fat cells (adipocytes) may originally come from cells in the bone marrow. Understanding the origin of fat cells is important because it may help to determine the health of fat cells and why fat that is stored in some places of your body is more ‘unhealthy’ than other fat.
Men and women: Between the ages of 18 and 75 years AND Had an allogeneic hematopoietic stem cell transplant at least 6 months ago –OR– Have chronic phase chronic myeloid leukemia.
8/21/2017Nutritional and Metabolic Diseases
Are you looking for an alternative treatment for your insomnia?
The purpose of this pilot study is to learn more about treatments for insomnia. Long-term use and dependence on controlled substance sleep medications (also known as “hypnotics”) is a common issue and is a less than ideal way to treat insomnia. Stopping the use of sleeping pills and trying other treatments for insomnia is difficult for many insomnia patients. Treatments combining supervised medication tapering (SMT), which is a gradual reduction of medication use, and cognitive behavioral insomnia therapy for insomnia (CBT-I), which is a form of talk therapy that helps a person learn to better handle behaviors, habits and thoughts that lead to sleeping problems., help some who wish to stop using sleep aids, but many individuals who complete these treatments do not give up their sleep aids altogether. This project will look at how to best help insomnia patients transitioning from using sleep aids to other treatment options for their insomnia.
• Adults 21 years of age and older who have chronic insomnia • Current medication use for treatment of chronic insomnia (over one year) • Desire to stop medication use
8/21/2017Behaviors and Mental Disorders
Participants needed for a study with Diabetes and couples health behaviors
This is a couples-based approach for increasing physical activity among adults with type 2 diabetes. Increasing physical activity has been shown to have great health benefits for managing diabetes.
One partner (or both) has Type 2 Diabetes One partner (or both) has been sedentary Each member is willing to increase their current level of physical activity Between the ages of 30 and 69
8/21/2017Nutritional and Metabolic Diseases
Healthy men needed for cardiovascular study
The purpose of this research is to study how low testosterone affects the health of the heart and arteries in men.
- Men  50-75 years old, in general good health - No history of cancer, diabetes or heart disease - Non-smokers - Not currently taking medications to treat high blood pressure, cholesterol, taking testosterone therapy or exercising vigorously more than 2 days per week
8/21/2017Heart and Blood Diseases
Participants ages 7-65 undergoing upper endoscopy needed for Research Study
Determine the efficacy of the EnteroTracker String Test (EST)for monitoring inflammation in the esophagus. Compare analysis of the EST to biopsies taken during an upper endoscopy.
Diagnosed EOE or patients with symptoms of abdominal pain, vomiting, growth delay or malabsorption with an Upper Endoscopy scheduled at either Children’s Hospital Colorado or the University of Colorado Hospital. Other Exclusion criteria may apply.
8/21/2017Digestive System Diseases
Volunteers wanted for Asthma Research Study
Researchers at the University of Colorado is seeking volunteers for an asthma research study to learn how weight and dietary supplement typically found in watermelon (Citrulline) may relate to asthma.
You may be eligible to participate if you:  Are between the ages of 18 and 60 years old  Have been diagnosed with asthma by a healthcare provider  Are overweight (a body mass index of 30 or greater)  Are not pregnant, breastfeeding, or planning to get pregnant in the next 6 months  Do not currently smoke  Have not smoked more than 1 pack a day over the last 10 years
8/21/2017Respiratory Tract (Lung and Bronchial) Diseases
Breast Cancer. Genetic Testing and Health Insurance: A Research Study
The goal of this research study is to understand how breast cancer patients in Colorado are able to obtain genetic testing and how test results are used to make treatment decisions. We are interested in talking with all breast cancer patients and survivors diagnosed in Colorado
Are you a breast cancer patient or survivor? Were you diagnosed in 2009 or after? Were you diagnosed in Colorado? If you answered “YES” to all three questions, you are eligible. You do NOT have to have received genetic testing to be in this study!
8/21/2017Cancers and Other Neoplasms
Research on a new group intervention for pediatric autonomic dysfunction.
This research aims to evaluate a new group therapy intervention for youth with autonomic dysfunction and their parents.
Eligible families will have a teenager who is between 13 and 18 years old, has a diagnosis of autonomic dysfunction, dysautonomia, orthostatic intolerance, and/or POTS (postural orthostatic tachycardia syndrome), and has difficulty completing day-to-day activities like going to school, and/or has been experiencing anxiety or worries and/or low mood.
8/21/2017Behaviors and Mental Disorders
Balance After Baby Intervention
A research study at the University of Colorado to help women with gestational diabetes lose weight after pregnancy
You may qualify for this study if you:  Are at least 18 years old  Had GDM during your most recent pregnancy  Had no personal history of Type 1 or 2 diabetes  Your pre-pregnancy body mass index is between 18 and 50 kg/m2  Your 6 week postpartum body mass index is between 24 and 50 kg/m2 (>22 for Asians)  Have daily access to the internet
8/21/2017Nutritional and Metabolic Diseases
iPrEP: An Injectable PrEP Research Study
New products are being developed to help prevent HIV and YOU CAN HELP! iPrEP is looking for healthy men and transgender women who have sex with men to take part in a research study. Learn more about PrEP and a research study to develop new products to Prevent HIV.
IF YOU ARE: A healthy HIV-negative man or transgender woman A HIV-Negative Man or Transgender Woman 18 years of age or older Age 18 to 25 Available WEEKDAYS Available Weekdays
8/21/2017Immune System Diseases
Do you have Atopic Dermatitis (Eczema)?
To study eczema
Males and Females between 3 and 80 who have atopic dermatitis or males and females between 8 months and 80 who have a history of, or an active case of eczema hereticum (wide-spread herpes skin infection along with atopic dermatitis.
Type 2 Diabetes and Exercise Research Study
To research the effects of an investigational drug on exercise capacity and blood vessel function​.​
Person 30-60 with Type 2 diabetes who exercise vigorously less than one hour per week and have normal blood pressure. Must not have smoked for at least one year and have a BMI between 25-39.9.
Are you a Non-smoking Adult between the ages of 45 and 85?
We are interested in learning more about smoking related lung disease, and need healthy non-smoking participants.
45-85 years old Non-Hispanic White or African American No smoking history No evidence of lung disease

Contact Us

Brenda Crawford, Research Coordinator, (303) 724-5362

Building 500 - 13001 E. 17th Place, Campus Box C290, Aurora, CO 80045

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