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Mechanisms and Barriers in Nanomedicine

Future Dates TBA

There is a growing sentiment in the field that in order to increase the availability of nanodrugs for patients, the biological, pathophysiological, immunological and manufacturing/regulatory barriers to effective translation need to be addressed.

The goals of the two-day Mechanisms and Barriers in Nanomedicine workshop are to:

  • provide an educational forum on the barriers to nanoparticle translation;
  • provide a paradigm shift to overcome these problems; and
  • allow for open discussion among faculty, postdocs and graduate students, to trigger new ideas and concepts.
Untitled Document

Fundamental issues in nanomedicine



Complement and immune uptake of nanomedicines: lessons from iron oxide nanoworms

Dmitri Simberg


Keynote: Tumor-penetrating peptides in nanoparticle targeting

Erkki Ruoslahti


Where the wild things are: Perivascular regulation of tumor cell dormancy and drug resistance

Cyrus Ghajar


Immunotherapy targeting tumor microenvironment and opportunities for nanomedicine

Stephen Dow


Improving nano-drugs' therapeutic efficacy through their interaction with tumor microenvironment

Chezy Barenholz


Physical and chemical mechanisms  of targeting selectivity for  mRNA nanomedicines for tumor immunotherapy

Heinrich Haas


Nanobioconjugates delivered through multiple biobarriers regulate laminin-411 - Notch  pathways

Julia Ljubimova


Exploiting cells in the tumor microenvironment for nanovector based therapy

Biana Godin


The 4S parameters in the rational design of nanomedicines

Paolo Decuzzi


Biologics and peptides by a novel encapsulation process

Robert Prud'homme


Optimizing nanoparticle delivery of chemotherapeutics - The clinical challenge

Alberto Gabizon


Impact of nanoparticles on the tumor immunologic milieu: Promise and peril

Irene La-Beck


Nanoparticle-based MRI on tumor associated macrophages: preclinical and clinical utility

Natalie Serkova


Translation of a cancer nanotherapeutic into the clinic: A view from the trenches

Len Pagliaro


Preclinical immunotoxicity studies of nanotechnology-formulated drugs

Marina Dobrovolskaia


Perspective on nanomedicine climate and the science advances

Dorothy Farrell


Hyperthermia approaches for enhanced delivery of polymer therapeutics

Hamid Ghandehari


Biophysical barriers in respiratory drug delivery

Hugh Smyth


To target or not to target: Lessons from RNAi-based targeted lipid-based nanoparticles

Dan Peer


Extracellular vesicles-mediated penetration of therapeutic compounds in solid tumors

Ji Ho (Joe) Park


Nanoparticle-prodrug combination approach for treating neuroblastoma

Michael Chorny


Nanoghosts as a natural nonviral gene delivery platform for targeting cancers

Marcelle Machlouf


Best poster talks


Impact of Motif Organization on the Formation and Stability of Silk-Elastin like Protein Polymer Nanogels

Martin Jensen (University of Utah)


Nanoscale Colloids & Particles for High Intensity Focused Ultrasound (HIFU)-Initiated Imaging

Nicholas Blum (University of Colorado Boulder)


Hearing and seeing nanoparticle targeting with photoacoustic imaging

Jack Ho (Princeton University)


Event Sponsors

​​​CU School of PharmacyCU Cancer CenterQuidel​​

The AAPS Rocky Mountain regional discussion group (RMDG) is also a sponsor.