Ph-like ALL occurs in
approximately 15% of children and over 25% of young adults with ALL. It is
considered a high-risk subtype of B-cell precursor ALL, associated with poor
outcome. This Ph-like ALL FISH panel includes probes targeted to the CRLF2, JAK2, EPOR, CSF1R, ABL1, ABL2, and PDGFRB genes which have been implicated
in Ph-like ALL. Recent studies show that targeted therapies
using tyrosine kinase inhibitors against these gene alterations may improve
outcomes in these patients, and thus results from this FISH assay may guide
appropriate treatment for Ph-like ALL.