Protocol applications are to be submitted online. Please note the
Please allow adequate time for the online application process;
submission deadlines (especially for three-year renewals) cannot be extended.
Please use the username and password that you use to log into the
University system to access the eSirius website. (eSirius is behind the UC
Denver | AMC firewall, so you need to VPN in or be on campus in order to have
If you are doing a
three-year protocol renewal, in the Mailbox click on De Novo Reviews and
click on the protocol number in the list. You'll be directed to the De
Novo Review page. Fill in the requested information, click Save, and the
page will appear again displaying a button at the bottom that says, "Start
De Novo Review". Click this button. You will need to go through each
page of the protocol in order to submit the rewrite. Even if there are no
changes to be made to a section, you must trigger the Save function in each
section in order for it to display a green checkmark in the Table of Contents
(and enable it to be submitted).
Personnel to be named as associates on a protocol must be
identified in a master 'drop down' list in order for you to select associates
during the protocol application process. At present the Personnel
Qualifications (PQ) form will still be used to provide information about
personnel. One form for each person (Principal Investigator [PI] included)
named on the protocol must be submitted to the IACUC Office. Please allow
adequate time (at least 72 hours) for the PQ data for new people to be
activated in the system. Submit one signed PQ form for all NEW personnel so
that the IACUC can review their qualifications in concert with the submitted
protocol. Contact the IACUC Office if you have questions.
The PI must start the protocol and the PI must submit the
protocol. For lab personnel who write the protocol, the PI will need to
create the protocol and make sure that individual is listed on the Personnel
page. The individual will then be able view and have access to edit the
protocol. All protocol associates listed on the protocol will be able to view
only the protocol.
Strains: If you do not see your strain in the dropdown, for
external orders, please provide vendor name and the stock number (e.g. JAX #
002216). For rodent breeding colonies, please email IACUC@ucdenver.edu or use this
document to develop a standardized nomenclature. Please allow adequate time
(at least 72 hours) for the strain to be added to the system. The
Strains section is DIRECTLY linked to animal ordering. All strains must
be listed in this section or you will not be able to order them and any
transfers of unlisted strains will be significantly delayed.
Chemicals: Please use “contains” to search for chemicals. If you
do not see your chemical/experimental agent in the dropdown, please provide an
SDS and a CAS number, if available, and email IACUC@ucdenver.edu and email@example.com. Please
allow adequate time (at least 72 hours) for the agent to be added to the
provide PQ forms for new personnel to the IACUC office.
ensure you have a green check mark in each section in the Table of Contents
remember that only the PI can start and submit a protocol or amendment.
pre-review by a member of the veterinary staff is offered and highly suggested.
The deadline for pre review is 11 days prior to the normal deadline for a
meeting. Your protocol submission will be sent to a vet for comments and
returned to the investigator at least 4 days prior to the final meeting deadline
in order for suggested corrections to be made and the protocol re-submitted
before the regular deadline.
with eSirius is available by calling 303-724-9215.