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TL1 Program: Team Oriented Training across the Translational Sciences Spectrum (TOTTS)

Provides support for pre- and post-doctoral trainees to develop skills for conducting team oriented clinical and translational research (CTR) spanning the pre-clinical to population health spectrum.  Candidates will be co-mentored by faculty with diverse clinical and translational interests and expertise. 

Funding Support

  • ​​One year fellowship stipend at the NRSA/NIH level that can be supplemented by mentor with non-federal funds
  • Funding for this program is still under review by NIH, and awards are subject to final budget allocations
  • Pre-Doctoral Awards
    Stipend: $23,376
    Tuition & Fees: $11,740
    Travel: $1,220 to attend the national CTSA TL1 meeting
    Research Related Expenses: $4,200
    Post-Doctoral Awards
    Stipend: $50,316 (dependent on post graduate year).
    Tuition & Fees: $4,500
    Travel: $1,220 to attend the national CTSA TL1 meeting
    Research Related Fees: $8,500 

Who is eligible?

  • Pre-Doctoral PhD Students in their first, second or third year in a Biomedical Science, Behavioral Science, Analytical Health Science, Clinical Science, Rehabilitation Sciences, Pharmaceutical Sciences, Public Health programs, Nursing Sciences PhD program at CU Denver are eligible. 
  • Pre-Doctoral health professional doctorate students in their second or third year of a dentistry, medicine, nursing, pharmacy, physical therapy, or public health program.
  • Post-Doctoral clinical trainees completing a training program involving clinical research. This includes post-graduate medical residents or other post-doctoral clinical trainees, such as pharmacists, nursing, and rehabilitation.  Funding will be available for trainees for their second or third year of training (ie. PGY 2 or 3).
  • Post-doctoral veterinary trainees who will have completed their residency training and are pursuing a research fellowship full-time, either as part of a PhD or as a standalone program. 90% of the awardee’s time must be dedicated to research and the completion of the TOTTS program in the year of the award.   
  • Must be a US Citizen or Permanent Resident.
  • Must be a CCTSI member.

Application Instructions

Please create one PDF document for uploading into the online application. Required sections should be in the order listed below. Have all documents ready prior to accessing the online application as you will not be able to save and go back once you have uploaded and submitted your application. 

  • Face Page: Download and complete the facepage​​ and include as the first document in your application pacakge.
  • NIH Biosketch:
    Include a biosketch for the applicant, research mentor and translational mentor. A translational mentor is the person that you will shadow to understand the target audience that you are translating your research to for uptake.  For those working in a lab, this may be a clinician and for clinicians, this could be a community organization or a preclinical researcher.  For veterinary trainees, a translational mentor will be a human health professional engaged in clinical/translational research and associated with the CCTSI, whose area of interest is complementary to that of the candidate. Please contact Marion Sills (​) for assistance with identifying a suitable clinician translational mentor.  Please contact John Tentler ( for a lab-based translational mentor. For further details on mentorship selection, please see Program Requirements section.​
  • Proposal:
    Use Times New Roman or Arial 11-pt font or larger. Page margins no less than 1 inch on all four sides.
    In three pages, briefly describe your planned research during your doctoral or post-doctoral training period and its clinical and translational relevance; immersion experience with translational mentor agreed upon with your mentor; and personal statement of experiences that prepare you for clinical and translational research (include service activities, research, etc.), your mid and long-term career goals, and if relevant, explain any breaks in your scholarly activity.
  • Courses: Include all courses completed as a graduate student and or doctoral student at CU Denver and grades obtained. They do not have to be official transcripts.
  • Letters of Support: Your application must include letters of support (no longer than 1 page) from your: 1. research mentor, 2. translational mentor and 3. doctoral or post-doctoral program director.  

How to Apply

Submit Application
  • Submit the application online, attach a PDF of your materials.
  • The application attachment is a single PDF document that is comprised of a Face Page, NIH Biosketches, Proposal, Courses, and Letters of Support.

Program Requirements

  1. Must cite CCTSI support: Please refer to the How to Cite our CCTSI Grant for all publications, patents, or other tangible outcomes from this project during and after project completion.
  2. Completion of coursework to support the conduct of clinical and translational research.
    ​​ ​Courses for TOTTS Trainees According to Targeted Stream​​
    ​Clinical Pre-doctoral students and Post-doctoral trainees Biomedical Doctoral Students Veterinary Post-doctoral​
    ​Applied Biostatistics I and II (CSPH) ​Biostatistics (CSPH) Biostatistics (CSU)​
    ​Study design: Epidemiology and Design AND Conduct of Clinical Trials (CLSC, CSPH) Study design: Epidemiology​ or Design and Conduct of Clinical Trials (CLSC, CSPH) Study design: Epidemiology or Design and Conduct of Clinical Trials (CLSC, CSPH)​
    ​Critical Appraisal of CTR Studies (CLSC) Human Disease/Systems (Home program)​ Translational Biomedical Research and Animal Models Selection (CSU)​
    ​Conducting Clinical Trials for Investigators (CLSC) Biology/Health System (Home program)​ Writing Scientific Manuscripts and Grants (CSU)(Participation in Career Development Grant Review and Mock Study program)​
    ​Clinical and Health Outcomes (CLSC) Home Program requirement​ Grant Writing (CLSC)​
  3. Completion of Responsible Conduct of Research and Good Clinical Practice training.  This includes online, such as CITI, and face to face training. 
  4. TOTTS Seminars: Trainees are expected to participate in once monthly 3-4 hour seminars to develop skills aligned with the NIH CTR core competencies and promote successful team oriented translational research.   Activities and topics include discussing research issues from a T0.5 to T4 perspective, leadership, working in teams and conducting team oriented science, entrepreneurship, working in communities, translating research across target audiences (patients, citizens, researchers, clinicians, funders, and policy makers), and providing opportunities for networking.
  5. Participation in CO-Mentor​: TOTT is committed to providing excellent mentorship to our trainees and their mentors. CO-Mentor’s aims are to: 1) develop skills and behaviors consistent with effective mentoring relationships; 2) enhance the specific mentor-mentee relationship; and 3) build a network of trained mentors and mentees who could model these practices for others, leading to a sustainable culture of mentoring at CCTSI institutions.  CO-Mentor consists of four half-day sessions.
  6. Immersion with Translational Mentor​: Each trainee will identify a translational mentor that will be a liaison to the community of the target audience appropriate to the trainee’s area of research. For trainees in a biomedical PhD program or part of the post-doctoral DVM track, having a clinical experience is crucial to understanding the context of human disease and illness and for developing interdisciplinary communication and team work. Each PhD biomedical and DVM trainee will have a clinical mentor who works with the trainee to develop a clinical experience relevant to the trainee. Trainees in doctoral health professional degree or medical residency programs will identify a translational mentor and have the option of developing an immersion experience in a biomedical lab or a health-oriented patient advocacy community relevant to the trainee. Requirements for the immersion experience include: 1) attending an orientation, 2) shadowing their mentor, understanding the patient’s experience with their disease, and discussing medical problems of patients relevant to their research, and 3) maintaining a reflective diary with entries made on patients seen during each clinical attendance. The frequency of clinic attendance will be tailored to each individual project.
  7. Attendance/Participation at the national CTSA conference.
  8. Fulfilling NIH/NCATS Reporting Requirements. Completion of materials and requests for information to meet NIH/NCATS reporting requirements.

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