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University of Colorado Denver

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Pharmaceutical Sciences

Symposia


2012 Symposia

 

 

June 14, 2012 - Drug Delivery Symposium Honoring Prof. Vincent H. L. Lee  at University of Colorado School of Pharmacy. Event open to all at the University of Colorado.

Agenda

June 15-16, 2012Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside (ARVO Summer Eye Research Conference sponsored in part by the National Eye Institute)

http://www.arvo.org/sites/conference/drug-gene


 

Past Symposia

​​​​Translational Therapeutics and Biomarkers

Thursday, September 15, 2011

Drug Stability, Delivery & Safety

Thursday, September 22, 2011

 

Translational Therapeutics and Biomarkers


Sponsored By

The Department of Pharmaceutical Sciences Toxicology Program

Commemorating the Dedication of the
Skaggs School of Pharmacy & Pharmaceutical Sciences

Thursday, September 15, 2011 - Seminar Room, V20-1000

SPEAKER INFORMATION

 

1:00 p.m.

Christopher P. Austin, M.D.
Director, NIH Chemical Genomics Center
Therapeutics for Rare and Neglected Diseases Program
NIH Center for Translational Therapeutics
http://www.genome.gov/11008455

"Translational Therapeutics Development at NIH"

Publications

1.

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.

 

Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR.

 

Environ Mol Mutagen. 2011 Aug;52(7):547-61. doi: 10.1002/em.20656. Epub 2011 Apr 27.

 

PMID: 21538559 [PubMed - in process]

 

Related citations

2.

Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

 

Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA, Dix DJ, Judson RS, Witt KL, Kavlock RJ, Tice RR, Austin CP.

 

Environ Health Perspect. 2011 Aug;119(8):1142-8. Epub 2011 May 4.

 

PMID: 21543282 [PubMed - in process] Free Article

 

Related citations

3.

Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.

 

Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK.

 

Cell Mol Neurobiol. 2011 Aug;31(6):901-7. Epub 2011 May 20.

 

PMID: 21598037 [PubMed - in process]

 

Related citations

4.

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.

 

Leister KP, Huang R, Goodwin BL, Chen A, Austin CP, Xia M.

 

Curr Chem Genomics. 2011;5:21-9. Epub 2011 May 10.

 

PMID: 21643507 [PubMed] Free PMC Article

 

Free full text Related citations

5.

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

 

Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ.

 

Science. 2011 Aug 5;333(6043):724-9.

 

PMID: 21817045 [PubMed - indexed for MEDLINE]

 

Related citations

6.

Discovery, Synthesis, and Biological Evaluation of Novel SMN Protein Modulators.

 

Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP.

 

J Med Chem. 2011 Aug 19. [Epub ahead of print]

 

PMID: 21819082 [PubMed - as supplied by publisher]

 

Related citations

7.

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.

 

Huang W, Huang R, Attene-Ramos MS, Sakamuru S, Englund EE, Inglese J, Austin CP, Xia M.

 

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5239-43. Epub 2011 Jul 21.

 

PMID: 21831635 [PubMed - in process]

 

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2:00 p.m.

Dean P. Jones, Ph.D.
Professor of Medicine
Director, Clinical Markers Lab
School of Medicine
Emory University
http://med.emory.edu/faculty/profile_highlights.cfm?id=128

"Redox systems biology: toward a mechanistic basis for personalized medicine and predictive therapeutics"

Publications

1.

A sulfur amino Acid-free meal increases plasma lipids in humans.

 

Park Y, Le NA, Yu T, Strobel F, Gletsu-Miller N, Accardi CJ, Lee KS, Wu S, Ziegler TR, Jones DP.

 

J Nutr. 2011 Aug;141(8):1424-31. Epub 2011 Jun 15.

 

PMID: 21677075 [PubMed - in process]

 

Related citations

2.

Oxidative stress is associated with impaired arterial elasticity.

 

Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, Dabhadkar K, Brigham K, Hooper WC, Alexander RW, Jones DP, Quyyumi AA.

 

Atherosclerosis. 2011 May 6. [Epub ahead of print]

 

PMID: 21605864 [PubMed - as supplied by publisher]

 

Related citations

3.

Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.

 

Go YM, Kang SM, Roede JR, Orr M, Jones DP.

 

PLoS One. 2011 Apr 15;6(4):e18918.

 

PMID: 21526215 [PubMed - indexed for MEDLINE] Free PMC Article

 

Free full text Related citations

4.

Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2.

 

Fitzpatrick AM, Stephenson ST, Hadley GR, Burwell L, Penugonda M, Simon DM, Hansen J, Jones DP, Brown LA.

 

J Allergy Clin Immunol. 2011 Jun;127(6):1604-11. Epub 2011 Apr 22.

 

PMID: 21514635 [PubMed - indexed for MEDLINE]

 

Related citations

5.

Mapping the cysteine proteome: analysis of redox-sensing thiols.

 

Jones DP, Go YM.

 

Curr Opin Chem Biol. 2011 Feb;15(1):103-12. Epub 2011 Jan 7. Review.

 

PMID: 21216657 [PubMed - indexed for MEDLINE]

 

Related citations

6.

Cysteine/cystine redox signaling in cardiovascular disease.

 

Go YM, Jones DP.

 

Free Radic Biol Med. 2011 Feb 15;50(4):495-509. Epub 2010 Dec 3. Review.

 

PMID: 21130865 [PubMed - indexed for MEDLINE]

 

Related citations

7.

Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans.

 

Jones DP, Park Y, Gletsu-Miller N, Liang Y, Yu T, Accardi CJ, Ziegler TR.

 

Nutrition. 2011 Feb;27(2):199-205. Epub 2010 May 14.

 

PMID: 20471805 [PubMed - indexed for MEDLINE]

 

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3:00 p.m.

Martyn T. Smith, Ph.D.
Professor, Division of Environmental Health Sciences
School of Public Health
University of California Berkeley
http://coeh.berkeley.edu/people/faculty/smithmartyn.htm

"Characterizing the exposome to complement the genome"

Publications

1.

Benzene, the exposome and future investigations of leukemia etiology.

 

Smith MT, Zhang L, McHale CM, Skibola CF, Rappaport SM.

 

Chem Biol Interact. 2011 Jun 30;192(1-2):155-9. Epub 2011 Feb 17.

 

PMID: 21333640 [PubMed - indexed for MEDLINE]

 

Related citations

2.

Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.

 

Ren X, Lim S, Ji Z, Yuh J, Peng V, Smith MT, Zhang L.

 

PLoS One. 2011 Jan 18;6(1):e14546.

 

PMID: 21267443 [PubMed - indexed for MEDLINE] Free PMC Article

 

Free full text Related citations

3.

Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene.

 

Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Ji Z, Vermeulen R, Yin S, Rothman N, Smith MT.

 

Carcinogenesis. 2011 Apr;32(4):605-12. Epub 2011 Jan 7.

 

PMID: 21216845 [PubMed - indexed for MEDLINE]

 

Related citations

4.

Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.

 

Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT, Zhang L.

 

Environ Health Perspect. 2011 Jun;119(6):771-7. Epub 2010 Dec 29.

 

PMID: 21193388 [PubMed - in process] Free PMC Article

 

Free full text Related citations

5.

Global gene expression profiling of a population exposed to a range of benzene levels.

 

McHale CM, Zhang L, Lan Q, Vermeulen R, Li G, Hubbard AE, Porter KE, Thomas R, Portier CJ, Shen M, Rappaport SM, Yin S, Smith MT, Rothman N.

 

Environ Health Perspect. 2011 May;119(5):628-34. Epub 2010 Dec 13.

 

PMID: 21147609 [PubMed - in process] Free PMC Article

 

Free full text Related citations

6.

Association of HLA-DQB1 alleles with risk of follicular lymphoma.

 

Akers NK, Curry JD, Conde L, Bracci PM, Smith MT, Skibola CF.

 

Leuk Lymphoma. 2011 Jan;52(1):53-8. Epub 2010 Dec 6.

 

PMID: 21133715 [PubMed - indexed for MEDLINE]

 

Related citations

7.

Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions.

 

Novak R, Zeng Y, Shuga J, Venugopalan G, Fletcher DA, Smith MT, Mathies RA.

 

Angew Chem Int Ed Engl. 2011 Jan 10;50(2):390-5. No abstract available.

 

PMID: 21132688 [PubMed - indexed for MEDLINE]

 

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Drug Stability, Delivery & Safety


Sponsored By

The Department of Pharmaceutical Sciences
Pharmaceutical Sciences Program

Commemorating the Dedication of the
Skaggs School of Pharmacy & Pharmaceutical Sciences

Thursday, September 22, 2011 - Seminar Room, V20-1000

9:00 a.m.

Theodore Randolph, Ph.D.
Gillespie Professor
Chemistry and Bio Engineering
Co-Director, Center for Pharmaceutical Biotechnology
University of Colorado Boulder

Phases, interfaces, and biopharmaceuticals

10:00 a.m.

Ram I. Mahato, Ph.D.
Professor of Pharmaceutical Sciences
Protein/Nucleic Acid Delivery and Targeting
2010 Fellow, American Association of Pharmaceutical Scientists (AAPS)
University of Tennessee Health Sciences Center

"Combination of stem cells and gene therapy for improved human islet transplantation”

11:00 a.m.

Wim Jiskoot, Ph.D.
Professor, Drug Delivery, Biologics Formulation Group
Leiden/Amsterdam Center for Drug Research, Drug Delivery Technology

"Unwanted immunogenicity of therapeutic proteins

 


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