Mailing address:
University of Colorado School of Pharmacy
Mail Stop C238
12850 E. Montview Blvd. V20-4130
Aurora, CO 80045
Office Location:
Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4130
Lab Location:
Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4460D(N)/4470
Contact:
Affiliations:
- Member, University of Colorado Cancer Center
- Member, Pharmacology Gradute Program
- Member, Biomedical Sciences Graduate Program
Training and Education:
- BS, Massachusetts Institute of Technology (Biology)
- PhD, University of Washington, Seattle (Pharmacology)
Clinical / Research Interests:
My research focus concerns the general study of inflammation in the context of disease with a more specific focus on factors that modify transcriptional regulation. The three major disease states in which I work include arthritis, diabetes, and cancer. Inflammation represents the body’s response to danger which may involve infection, acute tissue damage (trauma), or chronic tissue damage (inflammatory diseases). Cells such as macrophages and dendritic cells play complex roles in this process; first acting as soldier and then as healer. The process by which this occurs involves the genomic reorganization of the cell and is poorly understood. Other cells of the body contribute signals which strongly affect this process in a manner that is intensely situational. Within this complexity, we are focused on both understanding the signaling circuitry that comes into play and the identification of targets for therapeutic intervention. Additionally, I have formed a close collaboration with Uday Kompella and together we are generating nano-formulations which deliver transcriptional modulators to diseased tissues. We are currently focused on the delivery of siRNA therapeutics to specific cell types via the molecular programming of these formulations.
Teaching:
- Professional Program: Biochemistry, Pharmacology
Representative Publications:
- Wheat, W., Kupfer, R., Gutches, D.G., Rayat, G.R., Beilke, J., Scheinman, R.I., and Wegmann, D.R. (2004) Increased NF-kB activity in B cells and bone marrow derived DC from Non-obese Diabetic (NOD) Mice. European J. Immunol. 34(5):1395-404.
- Lang, J.A., Kominski, D., Bellgrau, D., and Scheinman, R.I. (2004) Partial Activation Precedes Apoptotic Death in T Cells Harboring an IAN Gene Mutation. European J. Immunol. 34:2396-2406.
- Tao, Y., Kupfer, R., Stewart, B., Williams-Skipp, C., Crowell, C., Patel, D.D. Sain, S. and Scheinman, R.I. (2006) AIRE Recruits Multiple Transcriptional Components to Specific Genomic Regions Through Tethering to Nuclear Matrix. Molecular Immunology 43:335-45
- Kupfer, R. Lang, J., Williams-Skipp, C., Nelson, M., Bellgrau D., and Scheinman, R.I. (2006) Loss of an gimap/ian Gene leads to Activation of NF-κB Through a MAPK Dependent Pathway. Molecular Immunol. In press
- Crowell, CK, Grampp, GE, Rogers, GN, Miller, J, and Scheinman, RI. (2006) Amino Acid and Manganese Supplementation Modulates the Glycosylation state of Erythropoietin in a CHO culture system. Biotechnology and Bioengineering. In press.
Keywords:
NF-κB, Arthritis, Diabetes, Inflammation, TNF, Signal transduction, Autoimmunity, Negative selection, Thymic selection, AIRE, Autoimmune Regulator