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University of Colorado Denver

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Lori Dwyer Nield, PhD

Research Associate Professor, Department of Pharmaceutical Sciences


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Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-4127
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4127

Lab Locations:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4127

Eastern Colorado Veterans Administration Health Sciences Center
Building 19, Room 307
1055 Clermont St.
Denver, CO 80220

Contact:

  • Voice: 303-724-3392
  • Lab (AMC): 303-724-3391
  • Lab (VA): 303-399-8020 x3625
  • Fax: 303-724-7266
  • E-Mail: Lori.Nield@ucdenver.edu

Training and Education:

  • BS (1984)-Biochemistry-University of Wyoming, Laramie, Wyoming
  • PhD (1991)-Biochemistry-University of Kentucky, Lexington, Kentucky

Research Interests:

  • Lung Cancer Prevention:  Mechanism of PPARγ-mediated lung cancer development, effects of smoking on PPARγ agonism, new drug development.
  • Inflammation and Lung Cancer:  Macrophage polarization and recruitment in the progression of early lung lesions.
  • Genetics of Lung cancer Susceptibility: Genetic mapping of lung cancer and lung inflammation susceptibility loci, use of mouse models to study lung cancer susceptibility.

Representative Publications:

  • Redente, E.F., Dwyer-Nield, L.D., Merrick, D.T., Raina, I.K., Agarwal, R., Pao, W.,  Rice, P.L., Shroyer, K.R., and Malkinson, A.M. Tumor Progression Stage and Anatomical Site Regulate Tumor-Associated Macrophage and Bone Marrow-Derived Monocyte Activation. Am. J. Pathol., 176: 2972-2985, 2010.
  • Fritz, J.M., Dwyer-Nield, L.D., and Malkinson, A.M. Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation.  Mol. Cancer 10: 76, 2011.
  • Dwyer-Nield, L.D., McQuillan, J., Hill-Baskin, A., Radcliffe, R.A., You, M., Nadeau, J.H., and Malkinson, A.M.  Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains.  Int. J. Cancer, 126: 125-32, 2010. 
  • Fritz, J.M., Dwyer-Nield, L.D., Russell, B.M., and Malkinson, A.M.  The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers vs Non-smokers. J. Thoracic Oncology 5: 254-7, 2010.
  • Rice, P.L., Barrett, B.S., Fritz, J.M., Srebernak, M.C., Kisley, L.R., Malkinson, A.M., and Dwyer-Nield, L.D.  Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal-regulated kinase1/2 in lung epithelial cells.  Exp. Lung Res., 36: 558-71, 2011.