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University of Colorado Denver

 

Jennifer Kiser, PharmD

Assistant Professor, Department of Pharmaceutical Sciences


Associate Director, Center for Translational Pharmacokinetics and Pharmacogenomics

Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-4102
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4102

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4420A(S)

Contact:

Training and Education:

  • 7/2010-present - Doctor of Philosophy in Clinical Sciences, University of Colorado, Aurora, CO
  • 7/2003-1/2006 - Antiretroviral Clinical Pharmacology Fellowship; University of Colorado Denver, Denver, CO
  • 6/2001-6/2002 - Pharmacy Practice Residency; University of California San Diego Medical Center, San Diego, CA
  • 8/1997- 5/2001 - Doctor of Pharmacy University of North Carolina Chapel Hill, Chapel Hill, North Carolina

Clinical / Research Interests:

My research is aimed at determining concentration-effect relationships and conducting drug interaction studies with antiviral drugs. I am particularly interested in characterizing antiviral pharmacology in persons with viral hepatitis and HIV-infected special patient populations including infants, children, adolescents, and pregnant women and persons coinfected with viral hepatitis. Our laboratory is a leader in development and application of state-of-the-art methods for quantifying antiviral drugs in various biologic matrices.

Teaching:

Professional Program

  • PHRD 7085 Pharmacotherapy 6
  • PHRD 6925 Medicinal Chemistry
  • PHRD 6915 & PHRD 7015 Seminar Research Course

Graduate Program

  • PHSC 7330 Development of Drugs and Biologics
  • PHSC/TXCL 7665 Pharmacokinetic Principles and Applications
  • TXCL 7561 Drug Metabolism & Pharmacogenetics

Selected Original Research Publications:

  1. Jimmerson LC, Ray ML, Bushman LR, Anderson PL, Klein B, Rower JE, Zheng J-H, Kiser JJ*. Determination of Intracellular Ribavirin Mono-, Di-, and Triphosphate Concentrations by Solid Phase Extraction and HPLC-MS-MS Detection. J Chrom B EPub Dec 17, 2014.
  2. Rutstein RM, Samson P, Fenton T, Matthews M, Fletcher CV, Kiser JJ, Smith E, Mofenson LM, Graham B, Aldrovandi G. Long-Term Safety and Efficacy of Atazanavir-Based Therapy in HIV-Infected Infants, Children and Adolescents: The Pediatric AIDS Clinical Trials Group Protocol 1020A. Pediatr Infect Dis J. EPub Sep 17 2014
  3. Moorehead KJ, Burton JR, Jr., Everson GT, J-H Zheng, Kerr BJ, Bushman LR, Wang M, Ju C, Nydam T, Kiser JJ*. Intrahepatic Antiviral Quantification in a Patient Undergoing Orthotopic Cadaveric Liver Transplantation. J Antimicrob Chemother. 2015;70(1):315-7.
  4. Chen X, Bushman LR, McAllister K, Anderson PL*, Kiser JJ. Validation of a sensitive LC/MS/MS method for the determination of telaprevir and its R-isomer in human plasma. Biomed Chromatogr. 2014 Dec;28(12):1714-21.
  5. Havens PL, Hazra R, Stephenson C, Kiser JJ, Flynn P, Wilson C, Rutledge B, Bethel J, Pan C, Woodhouse L, Van Loan M, Liu N, Lujan-Zilbermann J, Baker A, Kapogiannis B, Gordon C, Mulligan K. Vitamin D3 Supplementation Increases Fibroblast Growth Factor-23 in HIV-Infected Youth Treated with Tenofovir Disoproxil Fumarate. Antivir Ther. 2014;19(6):613-8.
  6. MacBrayne CE, Blum JD, Kiser JJ*. Tenofovir, Emtricitabine, and Darunavir/Ritonavir Pharmacokinetics in an HIV-Infected Patient post Roux-en-y Gastric Bypass Surgery. Ann Pharmacother 2014;48(6):816-9.
  7. Jimmerson LC, Zheng J-H, Bushman LR, MacBrayne CE, Anderson PL, Kiser JJ*. Development and validation of a dried blood spot assay for the quantification of ribavirin using liquid chromatography coupled to mass spectrometry. J Chrom B 2014;944:18-24.
  8. Hammond KP, Nielsen C, Linnebur SA, Langness JA, Ray G, Maroni P, Kiser JJ*. Priapism Induced by Boceprevir-CYP3A4 inhibition and Alpha-Adrenergic Blockade. Clinical Infectious Diseases 2014;58(1):e35-8.
  9. Havens PL, Kiser JJ, Stephensen C, Hazra R, Flynn P, Wilson C, Rutledge B, Bethel J, Pan C, Woodhouse L, van Loan M, Liu N, Lujan-Zilbermann J, Baker A, Kapogiannis B, Gordon C, Mulligan K. Association of higher plasma vitamin D binding protein and lower free calcitriol with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: Cause of a functional vitamin D deficiency. Antimicrobial Agents and Chemotherapy 2013;57(11):5619-28.
  10. Hammond KP, Wolfe P, Burton JR, Predhomme JA, Ellis CM, Ray ML, Bushman LR, Kiser JJ*. Pharmacokinetic Interaction between Boceprevir and Etravirine in HIV/HCV Seronegative Volunteers. JAIDS 2013;62(1):67-73.
  11. Castillo-Mancilla JR, Zheng JH, Rower JE, Meditz A, Gardner EM, Predhomme J, Fernandez C, Langness J, Kiser JJ, Bushman LR, Anderson PL. Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2013;29(2):384-90.
  12. Kiser JJ, Zhu R, D’Argenio DZ, Cotton MF, Bobat R, McSherry GD, Madhi SA, Carey VJ, Seifart HL, Werely CJ, Fletcher CV*. Isoniazid Pharmacokinetics, Pharmacodynamics, and Dosing in South African Infants. Therapeutic Drug Monitoring 2012;34(4):446-51.
  13. Carten MC, Kiser JJ, MaWhinney S, Kwara, Cu-Uvin S. Pharmacokinetic Interactions between the Hormonal Emergency Contraception, Levonorgestrel (Plan B®), and Efavirenz. Infectious Diseases in Obstetrics and Gynecology 2012;2012:137192.
  14. Aquilante CL*, Kiser JJ, Anderson PL, Christians U, Kosmiski LA, Daily EB, Hoffman KL, Hopley CW, Predhomme JA, Schneidewind B, Sidhom M. Influence of SLCO1B1 Polymorphisms on the Drug-Drug Interaction between Darunavir/Ritonavir and Pravastatin. Journal of Clinical Pharmacology 2012;52(11):1725-38.
  15. Zhu R, Kiser JJ, Seifart HI, Werely CJ, Mitchell CD, D’Argenio DZ*, Fletcher CV. Pharmacogenetics of NAT2 Enzyme Maturation in HIV Perinatally Exposed Infants Receiving Isoniazid.Journal of Clinical Pharmacology 2012;52(4):511-9.
  16. Baheti G, Kiser JJ, Havens PL, Fletcher CV*. Plasma and Intracellular Population Pharmacokinetic Analysis of Tenofovir in HIV-1 Infected Patients. Antimicrob Agents Chemother. 2011;55(11):5294-9.
  17. Roberts JL, Kiser JJ, Hindman J, Meditz A*. Virologic Failure on a Raltegravir-Containing Antiretroviral Regimen following the addition of calcium supplementation. Pharmacotherapy 2011;31(10):298e–302e.
  18. Bushman LR, Kiser JJ, Rower JR, Klein B, Zheng JH, Ray M, Anderson PL*. Determination of nucleoside analog mono-, di, and triphosphates in cellular matrix by solid phase extraction and ultrasensitive LC/MS/MS detection. Journal of Pharmaceutical and Biomedical Analysis 2011;56(2):390-401.
  19. Kiser JJ, Rutstein RM, Samson P, Graham B, Mofenson L, Smith E, Fenton T, Brundage RC, Fletcher CV*. Atazanavir and atazanavir/ritonavir pharmacokinetics in HIV-infected infants, children, and adolescents; Infant Maternal Pediatric Adolescent AIDS Clinical Trials Group P1020A. AIDS 2011;25(12):1489-96.
  20. Henderson KC, Hindman J, Johnson ST, Valuck RJ, Kiser JJ*. Assessing the effectiveness of pharmacy-based adherence interventions on antiretroviral adherence in persons with the human immunodeficiency virus. AIDS Patient Care STDS. 2011 Apr;25(4):221-8.
  21. Kiser JJ*, Bumpass JB, Meditz AL, Anderson PL, Bushman L, Ray M, Predhomme JA, Rower J, MaWhinney S, Brundage R. Effect of Antacids on the Pharmacokinetics of Raltegravir in Human Immunodeficiency Virus Seronegative Volunteers. Antimicrobial Agents and Chemotherapy 2010;54(12):4999-5003.
  22. Brousseau KM*, Filley CM, Kaye K, Kiser JJ, Adler LE, Connick E. Dementia with features of Alzheimer's disease and HIV-associated dementia in an elderly man with AIDS. AIDS 2009;23(8):1029-31.
  23. Kiser JJ, Gerber JG, Predhomme JA, Wolfe P, Flynn DM, Hoody DW*. Drug : Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers. JAIDS 2008; 47(5):570-578.
  24. Kiser JJ, Aquilante CL, Anderson PL, King T, Carten ML, Fletcher CV*. Clinical and Genetic Determinants of Intracellular Tenofovir Diphosphate Concentrations in HIV-Infected Patients. JAIDS 2008; 47(3):298-303.
  25. Kiser JJ, Fletcher CV, Flynn PM, Cunningham CK, Wilson CM, Kapogiannis BG, Major-Wilson H, Viani RM, Liu NX, Muenz LR, Harris RD, Havens PL*, and the Adolescent Trials Network for HIV/AIDS Interventions. Pharmacokinetics of Antiretroviral Regimens Containing Tenofovir Disoproxil Fumarate and Atazanavir/Ritonavir in Adolescents and Young Adults with HIV Infection – ATN056. Antimicrobial Agents and Chemotherapy 2008;52(2):631-7.
  26. Kiser JJ, Carten ML, Aquilante CL, Anderson PL, Wolfe P, King TM, Delahnuty T, Bushman L, Fletcher CV*. The Effect of Lopinavir/Ritonavir on the Renal Clearance of Tenofovir in HIV-Infected Patients. Clinical Pharmacology and Therapeutics 2008;83(2):265-272.
  27. Anderson PL*, Lichtenstein KA, Gerig NE, Kiser JJ, Bushman LR. Atazanavir-Containing Renal Calculi in an HIV-Infected Patient. AIDS 2007;21(8):1060-1062.
  28. King T, Bushman L, Kiser J, Anderson PL, Ray M, Delahunty T, Fletcher CV*. Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;843(2):147-56.
  29. Kiser JJ, Lichtenstein KA, Anderson PL, Fletcher CV*. Case Report: The Effects of Esomeprazole on the Pharmacokinetics of Atazanavir and Fosamprenavir in an HIV-Infected Patient. Pharmacotherapy 2006;26(4):511-4.

Recent Reviews:

  1. Kiser JJ*, Burton JR, Everson GT.  Drug interactions in viral hepatitis.  Nature Reviews Gastroenterology & Hepatology 2013;10(10):596-606.
  2. Kiser JJ*, Flexner CW.  Direct Acting Antiviral Agents for Hepatitis C Virus Infection.  Annual Reviews in Pharmacology and Toxicology 2013;53:427-49.
  3. Kiser JJ*, Burton JR, Anderson PL, Everson GT.  Review and Management of Drug Interactions with Boceprevir and Telaprevir.  Hepatology 2012;55(5):1620-8. 
  4. Anderson PL, Kiser JJ, Gardner E, Rower J, Meditz A, Grant R.  Pharmacologic considerations for tenofovir and emtricitabine to prevent HIV infection.  Journal of Antimicrobial Chemotherapy 2011;66:240-250.

 

Curriculum Vitae

Recent Publications

Center for Translational Pharmacokinetics and Pharmacogenetics