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University of Colorado Denver

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Gagan Deep, PhD

Assistant Professor Research, Department of Pharmaceutical Sciences


​​​Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-2116
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2116

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2450A

Contact:

Training and Education:

  • BS (1995) Kurukshetra University, India
  • MS (1997) Jawaharlal Nehru University, India
  • PhD (2004) Jawaharlal Nehru University, India

Research Interests:

  • Drug Discovery/Drug Development for Cancer Prevention and Therapy: Identify and target early molecular events and aberrant metabolism during carcinogenesis through anti-cancer small molecules and dietary agents.
  • Exosomes Research: Characterize exosomes to distinguish between indolent and lethal metastatic cancer. To understand exosomes role in tumor microenvironment remodeling, both local as well as distant metastatic niches. Identify and validate drugs targeting cancer specific exosomes loading and release.
  • Small animal molecular imaging: In vivo non-invasive imaging to monitor cancer growth, inflammation, metastasis and molecular biomarkers expression.  

Representative Publications:

  1. Deep G, Jain AK, Anand R, Vijendra KC, Ting H, Gangar SC, Agarwal C, Agarwal R. SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin. Molecular Cancer. 2014; 13(11):37
  2. Ramteke A, Ting H, Agarwal C, Mateen S, Somasagara R, Hussain A, Graner M, Frederick B, Agarwal R, Deep G. Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. Molecular Carcinogenesis. 2013
  3. Deep G and Agarwal R. Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy. Current Cancer Drug Targets. 2013; 13(5):486-99.
  4. Vijendra KC, Agarwal C, Agarwal R and Deep G. Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. PLoS One, 2011; 6(8): e22745.
  5. Deep G and Agarwal R. Anti-metastatic Efficacy of Silibinin: Molecular Mechanisms and Therapeutic Potential against Cancer. Cancer and Metastasis Reviews.2010; 29(3):447-63.
  6. Deep G, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008; 27: 3986-98.
  7. Singh RP, Deep G, Chittezhath C, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R. Effect of Silibinin on the Growth and Progression of Primary Lung Tumors in Mice. Journal of the National Cancer Institute. 2006; 98: 846-855. 
  8. Deep G, R P Singh, C Agarwal, D J Kroll and R Agarwal. Silymarin and silibinin cause G1 and G2–M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene. 2006; 25: 1053–1069.