Associate Director PK/PD, University of Colorado Cancer Center Pharmacology Core
Mailing address:
Skaggs School of Pharmacy and Pharmaceutical Sciences
University of Colorado
Mail Stop C238
12850 E. Montview Blvd. V20-4107
Aurora, CO 80045
Office Location:
Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4107
Lab Location:
Pharmacy and Pharmaceutical Sciences Building (V20)
Room 4410C
Contact:
Voice: 303-724-6577
E-Mail: Erica.Pierce@ucdenver.edu
Affiliations:
- Clinical Research Instructor, Department of Pharmacology, School of Medicine
- Faculty, Computational Biosciences Program, School of Medicine (Compbio)
- Member, University of Colorado Cancer Center (Developmental Therapeutics)
- Associate Director PK/PD, University of Colorado Cancer Center, Pharmacology Shared Resource (PharmacologyCore)
Training and Education:
- BS, Chemical Engineering, University of Minnesota, Minneapolis, MN
- PhD, Pharmaceutical Sciences (Cancer Pharmacology), University of Colorado Health Sciences Center, Denver, CO
- Post-Doctoral Fellow, Pharmacology of Anti-Neoplastic Agents, Division of Medical Oncology and Department of Anesthesiology
Other Training:
- 2nd Annual Workshop on Cancer Systems Biology, Tumor Metronomics: Timing and Dose Level Dynamics, Boston, MA. July 2012.
- In Vivo Small Animal Imaging Workshop, University of California Davis, CA. March 2008. Instructor: Dr. Simon Cherry
- Micro-PET Training, Siemens, Knoxville, TN. September 2007.
- International workshop on Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling and Risk Assessment. July 16-27, 2001.
Research Interests:
- Translational cancer pharmacology
- Quantitative in vivo pharmacology
- Translational biomarkers
- Tumor drug delivery
- Computational Modeling & Simulation: Quantitative systems pharmacology, multi-scale modeling, pharmacokinetic (PK)-pharmacodynamic (PD) modeling, physiologically-based pharmacokinetics
Selected Publications:
Morelli MP, Tentler JJ, Kulikowski GN, Tan AC, Bradshaw-Pierce EL, Pitts TM, Brown AM, Nallapareddy S, Arcaroli JJ, Serkova NJ, Hidalgo M, Ciardiello F, Eckhardt SG. (2011) Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS Mutant Colorectal Cancer Models. Clinical Cancer Research. 18(4): 1051-62 [PMID: 22173549]
Tentler JJ*, Bradshaw-Pierce EL*, Serkova NJ, Pitts TM, Bray MR, Fletcher G and Eckhardt SG. (2010) ENMD-2076, a Novel Multi-Targeted Kinase Inhibitor, Demonstrates Anti-Angiogenic and Anti-Proliferative activity in a Human Colorectal Cancer Xenograft Model. Clinical Cancer Research. 16(11): 2989-2998 *co-first author [PubMed ID: 20406842]
Serkova NJ, Renner B, Larsen B, Stoldt C, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. (2010) Non-Invasive Detection of Renal Inflammation Using Complement Receptor 2 Conjugated to Iron Oxide Nanoparticles. Radiology. 255(2):517-26. [PubMed ID: 20332377]
Serkova NJ, Garg K and Bradshaw-Pierce EL. (2009) Oncologic Imaging End-Points for the Assessment of Therapy Response. Recent Patents on Anti-Cancer Drug Discovery. 4(1):36-53. [PubMed ID: 19149687]
Bradshaw-Pierce EL, Steinhower C, Raben D and Gustafson DL. (2008) Pharmacokinetic-Directed Dosing of Vandetanib and Docetaxel in a Mouse Model of Human Squamous Cell Carcinoma. Molecular Cancer Therapeutic. 7(9): 3006-3017. [PubMed ID: 18790781]
Bradshaw-Pierce EL, Eckhardt SG and Gustafson DL. (2007) A Physiologically-Based Pharmacokinetic Model of Docetaxel Disposition: From Mouse to Man. Clinical Cancer Research. 13(9): 2768. [PubMed ID: 17473210]
Gustafson DL, Bradshaw-Pierce EL, Merz AL, Zirrolli JA. (2006) Tissue Distribution and Metabolism of ZD6474 in Tumor Bearing Nude Mice Following Oral Dosing. Journal of Pharmacology and Experimental Therapeutics. 318 (2) 872-880. [PubMed ID: 16644900]
Gustafson DL, Long ME, Bradshaw EL, Merz AL and Kerzic PJ. (2005) P450 Induction Alters Paclitaxel Pharmacokinetics. Cancer Chemotherapy and Pharmacology. 56(3): 248-254. [PubMed ID: 15856231]
Published Book Chapters:
Bradshaw-Pierce EL and Tan AC. (2013) Integrating “Omics” Data for Quantitative and Systems Pharmacology in Translational Oncology. In: Micro and Nano Flow Systems for Bioanalysis. Eds. Collins MW and König CS. Springer, New York.
Gustafson DL and Bradshaw-Pierce EL. (2011) Fundamental concepts in clinical pharmacology. In: Principles of Anti-Cancer Drug Development. Eds. Hidalgo M, Garrett-Mayer E, Clendeninn NJ and Eckhardt SG. Springer, New York.
Curriculum Vitae