Skip to main content
Sign In

University of Colorado Denver

 

Donald S. Backos, MPH, PhD

Assistant Research Professor, Computational Chemistry and Biology Core Facility Manager, Department of Pharmaceutical Sciences


Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Sciences
Mail Stop C238
12850 E. Montview Blvd. V20-2210
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2210

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor
Room 2210, 2420E(S)

Contact:

Affiliation:

  • Member - Colorado Clinical and Translational Sciences Institute

Training and Education:

  • BS, University of Michigan, Ann Arbor (Microbiology)
  • MPH, University of Michigan School of Public Health (Toxicology)
  • PhD, University of Colorado (Molecular Toxicology)
  • Postdoctoral Fellow, University of Colorado (Computational Chemistry and Biology)

Research Interests:

I oversee the Computational Chemistry and Biology (CCB) Core Facility, which provides a wide array of advanced tools and services for computational-based simulations and modeling of chemical and biological systems. The CCB Core offers specialized expertise and services to researchers in both academia and the biotech/pharmaceutical industries, including:

  • Protein sequence analysis, including phylogenetic / evolutionary trace analysis
  • Generation and analysis of macromolecular 3D structure (protein, DNA, RNA, and antibody)
  • Optimization of macromolecule geometry and conformation
  • Prediction of macromolecule interactions (e.g. protein-protein, protein-DNA, receptor-ligand, etc.)
  • Explicit or implicit solvent-based molecular mechanics and molecular dynamics simulations
  • Rational small molecule drug design
  • Virtual small molecule library screening
  • Evaluation of ligand quantitative structure activity relationships (QSAR)
  • Generation of pharmacophore models
  • Computational-based prediction of drug ADMET characteristics

In addition, the visualization of molecular structures and their interactions is an essential aspect of analyzing and communicating the results of modeling studies. I also specialize in the production of eye-catching figures, graphics, illustrations, and animations for grant submissions, manuscripts, reviews, and presentations.

For more information, please visit the CCB core website: http://www.tinyurl.com/CompChemCore

Publications:

Cover Illustrations:

Journal of Neuroscience, Aug 15, 2012 32(33), http://www.jneurosci.org/content/32/33.toc

Sirtuins – Methods in Molecular Biology, Vol 1077 (2013) http://www.springer.com/life+sciences/animal+sciences/book/978-1-62703-636-8

​​