Skip to main content
Sign In

University of Colorado Denver

​​​​​​​​​ ​
 

Christina Aquilante, PharmD

Associate Professor, Department of Pharmaceutical Sciences


Dr. Christina Aquilante

Mailing address:

University of Colorado
Skaggs School of Pharmacy and Pharmaceutical Science
Mail Stop C238
12850 E. Montview Blvd. V20-4103
Aurora, CO 80045

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4103

Lab Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Fourth Floor
Room 4420A

Contact:

Training and Education:

  • PharmD, University of North Carolina at Chapel Hill
  • Pharmacy Practice Residency, Shands Hospital at the University of Florida
  • Post-PharmD Research Fellowship in Cardiovascular Pharmacogenomics, University of Florida College of Pharmacy
  • Certificate in Clinical Science, University of Colorado Clinical Science Graduate Program

Research Interest:

Dr. Aquilante's patient-oriented clinical research program is aimed at identifying pharmacogenetic determinants of drug disposition, response, and adverse effects in cardiovascular and metabolic diseases. Her research has been continuously funded by the National Institutes of Health and/or the American Heart Association since 2006. Currently, Dr. Aquilante’s active clinical studies are focused on heart transplant recipients and patients with advanced heart failure. The primary goal of her work is to identify genetic predictors of drug disposition (pharmacokinetics), response (pharmacodynamics) and adverse effects in heart transplant recipients. She is also interested in identifying factors that influence medication regimen complexity and adherence in the heart transplant population. Recently, Dr. Aquilante has expanded her research program to include a cross-disciplinary and translational component. This approach is being used to elucidate mechanisms underlying left ventricular assist device (LVAD)-related adverse effects in patients with advanced heart failure.

Teaching:

Professional Program:
  • PHRD 5915 Modern Drug Design and Action
  • PHRD 6095 Pharmacotherapy 3
  • PHRD 6915/7025 Seminar Research Course
  • PHRD 7025 Pharmacogenomics (Course Coordinator)
  • PHRD 7801 Principles of Clinical Pharmacology
Graduate Programs:
  • PHSC/TXCL 7310 Fundamentals of Pharmaceutical Sciences
  • PHSC/TXCL 7400 Ethical Issues in Toxicology and Pharmaceutical Sciences
  • PHSC/TXCL 7665 Pharmacokinetic Principles and Applications
  • TXCL 7561 Drug Metabolism and Pharmacogenetics
  • CLSC 6260 Conducting Clinical Trials for Investigators
  • CLSC 7500 Practical Application of Molecular Biology Techniques for the Clinical Investigator

Representative Publications:

  • Aquilante CL, Kosmiski, LA, Zineh I, et al.  Pharmacodynamic effects of rosiglitazone in nondiabetic patients with the metabolic syndrome.  Pharmacotherapy.  2010; 30:236-47.
  • Aquilante CL, Kiser JJ, Anderson PL, Christians U, Kosmiski LA, et al.  Influence of SLCO1B1 Polymorphisms on the Drug-Drug Interaction between Darunavir/Ritonavir and Pravastatin.  J Clin Pharmacol 2012; 52:1725-38.
  • Aquilante CL, Kosmiski LA, Bourne DWA, et al.  Impact of the CYP2C8*3 polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone.    Br J Clin Pharmacol 2013;75(1):217-26. 
  • Aquilante CL, Wempe MF, Sidhom MS, Kosmiski LA, Predhomme JA.  Effect of ABCB1 polymorphisms and atorvastatin on sitagliptin pharmacokinetics in healthy volunteers.  Eur J Clin Pharmacol 2013;69(7):1401-1409.
  • Aquilante CL, Niemi M, Gong L, Altman RB, Klein TE.  PharmGKB summary:  very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8.  Pharmacogenet Genomics. 2013; 23(12):721-8.
  • Vu A, Sidhom MS, Bredbeck BC, Kosmiski LA, Aquilante CL.  Evaluation of the relationship between circulating omentin-1 concentrations and components of the metabolic syndrome in adults without type 2 diabetes or cardiovascular disease.  Diabetol Metab Syndr. 2014;6(1):4.
  • Aquilante CL, Page RL, Vu A, Roscoe N, Wolfel EE, Lindenfeld JA. Comparison of Office, Home, and Ambulatory Blood Pressure in Heart Transplant Recipients.  J Card Fail.  2014, in press.