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University of Colorado Denver

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PhD in Toxicology

Research Areas

Cancer

Faculty Member Research Interests
Rajesh Agarwal Cancer chemoprevention, phytochemicals, mitogenic signaling, cell-survival signaling, apoptosis, cell cycle
Dennis Ahnen Colon cancer, chemoprevention, molecular biology, molecular epidemiology,Non-steroidal anti-inflammatory drugs, signal transduction
Thomas Anchordoquy  
James Crapo  
Christopher Franklin Apoptosis, glutathione, oxidative stress, arsenic, gene expression, signal transduction, protein kinases, protein phosphatases
Brian Freed Cigarette smoking, pulmonary, T cell function, acrolein, hydroquinone, catechol
Dan Gustafson Cancer, chemotherapy, chemoprevention, molecularly targeted agents, cytotoxic agents, angiogenesis, pharmacokinetics, pharmacodynamics, enzymology
Richard Irons Hematoxicity, immunotoxicity, leukemia, lymphoma, alkylating chemotherapeutic agents, human hepatopoietic cells, mechanistic toxicology, benzene poisoning,epidemiology, disease progression, metabolism, Epstein Barr virus
Al Malkinson  
Joe McCord Free radicals, superoxide, superoxide dismutase, cancer, diabetes, oxidative stress
Robert Murphy Mass spectrometry, lipid mediators, eicosanoids
Lawrence Ng  
Linda Quattrochi Molecular toxicology; cytochrome P450 regulation; dioxin toxicity; chemoprevention; viral hepatitis; human/cells
David Ross Molecular toxicology, anticancer drug development, quinone reductases, NQO1, quinones, pharmacogenetics, benzene, dopamine, proteasomal inhibition
Robert Scheinman Gene regulation, transcription, NF-kappa B, immunology, T cell, autoimmunity
David Siegel Drug metabolism, quinone metabolism, quinone bioactivation, quinone reductase, pharmacogenetics, oxidative stress, superoxide scavenging, cancer pharmacology
Kathleen Stringer Inflammation, neutrophils, apoptosis, NADPH oxidase
John Thompson Drug metabolism, chemical toxicology, carcinogenesis, chemoprevention, antioxidants, mass spectrometry
Vasilis Vasiliou Cellular responses to oxidative stress, ethanol/acetaldehyde metabolism, aldehyde dehydrogenases, pharmacogenetics, humans/animals/cells, transgenic mice

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Clinical and Forensic Toxicology

Faculty Member Research Interests
Gregory Bogdan Acetaminophen, antidote development, animal venoms, cyanide, terrorism & disaster response, arsenic and lead
Richard Dart Acetaminophen (paracetamol), acetylcysteine, alcohol abuse, snake venom, black widow spider, terrorism, chemical warfare, opioid dependence, opioid addiction
Phillip Guzelian Cytochrome P450, hepatocyte culture, signal Transduction, receptor mediated induction, gene expression, steriod hormones
James Ruth Forensic Toxicology

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Hepatotoxicology

Faculty Member Research Interests
Lawrence Berliner Free radicals, in vivo EPR, ESR, spin traps, nitric oxide, superoxide, superoxide scavenging, molecular toxicology, drug metabolism, oxidative stress, antioxidants, protein structure and folding
Gregory Bogdan Acetaminophen, antidote development, animal venoms, cyanide, terrorism & disaster response, arsenic and lead
Richard Dart Acetaminophen (paracetamol), acetylcysteine, alcohol abuse, snake venom, black widow spider, terrorism, chemical warfare, opioid dependence, opioid addiction
Christopher Franklin Apoptosis, glutathione, oxidative stress, arsenic,gene expression, signal transduction, protein kinases, protein phosphatases
Phillip Guzelian Cytochrome P450, hepatocyte culture, signal Transduction, receptor mediated induction, gene expression, steriod hormones
Cynthia Ju Hepatic macrophages (Kupffer cells, KC), KC-mediated immunological tolerance, drug-induced immune- and non-immune-mediated liver injury, hepatic inflammation, animal/cells, transgenic mice
Dennis Petersen  
Linda Quattrochi Molecular toxicology; cytochrome P450 regulation; dioxin toxicity; chemoprevention; viral hepatitis; human/cells
Vasilis Vasiliou Cellular responses to oxidative stress, ethanol/acetaldehyde metabolism, aldehyde dehydrogenases, pharmacogenetics, humans/animals/cells, transgenic mice

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Immunotoxicology

Faculty Member Research Interests
Sonia Flores Inflammation and oxidant-stress mediated vascular complications in Type 1 diabetes, autoimmunity and NADPH-oxidase-mediated vascular dysfunction
Brian Freed Cigarette smoking, pulmonary, T cell function, acrolein, hydroquinone, catechol
Richard Irons Hematoxicity, immunotoxicity, leukemia, lymphoma, alkylating chemotherapeutic agents, human hepatopoietic cells, mechanistic toxicology, benzene poisoning, epidemiology, disease progression, metabolism, Epstein Barr virus
Cynthia Ju Hepatic macrophages (Kupffer cells, KC), KC-mediated immunological tolerance, drug-induced immune- and non-immune-mediated liver injury, hepatic inflammation, animal/cells, transgenic mice
Robert Scheinman Gene regulation, transcription, NF-kappa B, immunology, T cell, autoimmunity

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Neurotoxicology

Faculty Member Research Interests
Lawrence Berliner Free radicals, in vivo EPR, ESR, spin traps, nitric oxide, superoxide, superoxide scavenging, molecular toxicology, drug metabolism, oxidative stress, antioxidants, protein structure and folding
Lawrence Ng  
Manisha Patel Neuroscience, oxidative stress, mitochondria, epilepsy, excitotoxicity, neurodegeneration, neurotoxicology
Richard Radcliffe Neuroscience, neurotoxicology, alcoholism, alcohol tolerance, model organisms, drug abuse, molecular genetics, behavior genetics, gene expression microarrays, QTL mapping
David Ross Molecular toxicology, anticancer drug development, quinone reductases, NQO1, quinones, pharmacogenetics, benzene, dopamine, proteasomal inhibition

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Pharmacogenetics

Faculty Member Research Interests
Peter Anderson Antiretroviral drug therapy; HIV; Antiviral drug therapy; pharmacokinetics; pharmacodynamics
Dan Gustafson Cancer, chemotherapy, chemoprevention, molecularly targeted agents, cytotoxic agents, angiogenesis, pharmacokinetics, pharmacodynamics, enzymology
Phillip Guzelian Cytochrome P450, hepatocyte culture, signal Transduction, receptor mediated induction, gene expression, steriod hormones
Richard Irons Hematoxicity, immunotoxicity, leukemia, lymphoma, alkylating chemotherapeutic agents, human hepatopoietic cells, mechanistic toxicology, benzene poisoning, epidemiology, disease progression, metabolism, Epstein Barr virus
Robert Murphy Mass spectrometry, lipid mediators, eicosanoids
Dennis Petersen  
Linda Quattrochi Molecular toxicology; cytochrome P450 regulation; dioxin toxicity; chemoprevention; human/cells
David Ross Molecular toxicology, anticancer drug development, quinone reductases, NQO1, quinones, pharmacogenetics, benzene, dopamine, proteasomal inhibition
David Siegel Drug metabolism, quinone metabolism, quinone bioactivation, quinone reductase, pharmacogenetics, oxidative stress, superoxide scavenging, cancer pharmacology
John Thompson Drug metabolism, chemical toxicology, carcinogenesis, chemoprevention, antioxidants, mass spectrometry
Vasilis Vasiliou Cellular responses to oxidative stress, ethanol/acetaldehyde metabolism, aldehyde dehydrogenases, pharmacogenetics, humans/animals/cells, transgenic mice

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Pharmacogenomics

Faculty Member Research Interests
James Crapo  
Phillip Guzelian Cytochrome P450, hepatocyte culture, signal Transduction, receptor mediated induction, gene expression, steriod hormones
Dennis Petersen  
Richard Radcliffe Neuroscience, neurotoxicology, alcoholism, alcohol tolerance, mice/zebrafish, drug abuse, genetics, microarrays, QTL mapping, fear conditioning
David Ross Molecular toxicology, anticancer drug development, quinone reductases, NQO1, quinones, pharmacogenetics, benzene, dopamine, proteasomal inhibition
David Siegel Drug metabolism, quinone metabolism, quinone bioactivation, quinone reductase, pharmacogenetics, oxidative stress, superoxide scavenging, cancer pharmacology
Vasilis Vasiliou Cellular responses to oxidative stress, ethanol/acetaldehyde metabolism, aldehyde dehydrogenases, pharmacogenetics, humans/animals/cells, transgenic mice

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Pulmonary Toxicology

Faculty Member Research Interests
Lawrence Berliner Free radicals, in vivo EPR, ESR, spin traps, nitric oxide, superoxide, superoxide scavenging, molecular toxicology, drug metabolism, oxidative stress, antioxidants, protein structure and folding
James Crapo  
Brian Day  
Sonia Flores HIV Tat protein-mediated lung oxidant stress, superoxide dismutase regulation, oxidant-mediated regulation of gene expression
Al Malkinson Genetic analysis of mouse lung tumor formation, role of inflammation in lung neoplasia, chemoprevention
Joe McCord Free radicals, superoxide, superoxide dismutase, cancer, diabetes, oxidative stress
Carl White Role of oxidation-reduction status in lung health and disease.Oxidant-antioxidant balance in acute and chronic lung injury. Signal transduction in pulmonary endothelial and epithelial cells

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