Department of Medicine
University of Colorado Denver
1. EXERCISE AND THE CARDIOVASCULAR SYSTEM (diabetes, peripheral arterial disease)
2. BUILDING INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN’S HEALTH
2000-2012 Investigator: Look AHEAD trial to reduce obesity in persons with type 2 diabetes. NIDDK (James Hill, PI) (10% effort)
2003-2009 Principal Investigator, Subcontract: 1 R01 HL075752-01 Angiogenesis and mechanisms of exercise training in PAD (at University of Colorado Health Sciences Center only)
2005-2010 Co-Investigator, 1UO1 HL077221-01A1 Claudication: Exercise Vs.Endoluminal Revascularization
2007-2012 Principal Investigator and Program Director, 1 K12 HD057022-01.NIH. Building Interdisciplinary Careers in Women’s Health
2007-2010 Co-Principal Investigator. VA Merit Award. Impact of lipid infusion on Functional Exercise Capacity.
2008-2011 Principal Investigator. American Diabetes Association. Influence of Endothelial Function on Central vs. Peripheral Causes of Exercise Impairment in Type 2 Diabetes.
2009-2011 Principal Investigator. Amylin Pharma. Investigated Initiated Grant: Effects of Exenatide on Exercise Performance in Type 2 Diabetes.
Description of Research
We study how disease can affect the ability to exercise and how to use exercise and pharmacologic therapies to improve exercise capacity. Our goal is to use exercise as a tool to understand the effects of disease on the cardiovascular system and to look at ways to remedy the abnormalities.
We are currently evaluating the influence of endothelial function on central vs peripheral causes of exercise impairment in type 2 diabetes. We are also looking at the effects of a drug which has cardiac benefit on exercise capacity in type 2 diabetes.
As the director of the Center for Women’s Health Research, we have a grant entitled, Building Interdisciplinary Research Careers in Women’s Health which supports junior faculty as they develop their careers in women’s health.
1-2 Most Significant Publications
1) Regensteiner JG, Bauer TA, Reusch JEB, Quaife RA, Chen MY, Smith SC, Miller TM, Groves BM, Wolfel EE. Cardiac dysfunction during exercise in uncomplicated type 2 diabetes. Med Sci Sport Exerc 2009;41:977-984.
2) Nadeau K. Zeitler P, Bauer T. Brown MS, Dorosz J, Draznin B, Reusch JEB, Regensteiner JG. Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. Journal Clin Endo Metab
Primary Focus Area: Exercise and the Heart
Access to Specialized Populations
· Women with diabetes
Benefit of CNRU
The major benefit of the CNRU for me has been the enhanced interaction and collaboration with other CNRU investigators. Additionally, the CNRU allows me to interact with junior investigators through the pilot project program and through the core laboratories. The core laboratories of the CNRU are critical to my research success. These laboratories provide services in a cost-effective manner that I could not develop in my own laboratory.
CNRU Cores Used
Energy Balance, Metabolic
CNRU CollaborationsHill, Eckel, Van Dorsten, Reusch, Schauer, Nadeau, Hamman, Kohrt