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University of Colorado Denver

University of Colorado Denver


Faculty Profile

Assistant Professor

Department of Pediatric Endocrinology

University of Colorado Denver


Insulin Resistance in Type 1 and Type 2 diabetes in Youth


Grants:-1K23 RR020038-05 “Insulin Control of Fat Regulation and Exercise in Teens”

              -2 JDRF5-2008-291 (Nadeau Kristen PI) “Insulin Sensitivity in Adolescents with Type 1 and Type 2 Diabetes”

              3-University of Colorado CTSI Co-Pilot Grant  “Muscle Metabolism in Youth with Type 1 and Type 2 Diabetes”

             4-1UO1 DK 61242-01 “Prevention and Treatment of Type 2 Diabetes in Children and Adolescents”

             5-1R56DK078645  “Regulation of Maternal Fuel Supply and Neonatal Adiposity”

             6-RO1# Pending  NIH/NID “Regulation of Maternal Fuel Supply and Neonatal Adiposity”


Description of Research

        I am currently focused on the idea of a unique phenotype of IR in T1D, and the early cardiovascular abnormalities in T1D and T2D youth. I wish to better understand the mechanism(s) of IR in pediatric DM and identify treatment targets for interventions to improve IR.


1-2 Most Significant Publications

1. Nadeau KJ, Bauer T, Brown M, Doroscz J, Zeitler P, Draznin B, Reusch JEB, Regensteiner JG. Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab, July 7 2009. (epub ahead of print). [PMID: 19584191].

2. Nadeau KJ, Ehlers, Lindsay, Zeitler, PS, Fenton, L,

Love-Osborne, K,: Treatment of non-alcoholic fatty liver

Disease with metformin versus lifestyle intervention in

Insulin resistant adolescents. Pediatric Diabetes, Aug 20

2008. Pediatric Diabetes, [Epub ahead of print], 2009

Feb;10(1):5-13. [PMID:18721166].


Primary Focus Area (if part of the obesity initiative)

Secondary Focus Areas (if part of the obesity initiative)

Access to Specialized Populations

·         TODAY study of youth with type 2 diabetes

·         Youth with type 1 and type 2 diabetes and metabolic syndrome


Benefit of CNRU

The major benefit of the CNRU for me has been the enhanced interaction and collaboration with other CNRU investigators, and learning new laboratory techniques. As a junior investigator through the pilot project program, it has provided me with mentorship and support.  The funding provided by the CRNU has allowed me to begin my first clinical research project. This support was also critical to the application and receipt of a NIH K23 grant. The CRNU support has allowed me to enter the field of clinical research, and provide a spring board to continuing clinical research as an independent investigator in the future.


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