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University of Colorado Denver

University of Colorado Denver


Faculty Profile

Professor and Chairman, Department of Pediatrics

University of Colorado Denver School of Medicine

Pediatrician-in-Chief and L. Joseph Butterfield Chair of Pediatrics

The Children's Hospital, Denver


Co-Investigator - 2000-2010 - Centers for Disease Control, Childhood Diabetes:  Prevalence, Incidence and Characteristics (Search for diabetes in youth), 5% Effort; Total Direct Costs: $3,140,883.  Lawrence Dolan, MD, Principal Investigator. 


R01 HL076269 Principal Investigator - 2005-2009 - National Institutes of Health, CV Disease in Adolescents with Type 2 Diabetes, 20% Effort; Total Direct Costs: $2,343,340.    


Co-Investigator R01 DK071485-01 (Sun) NIH  9/30/2004 - 7/31/2009

Childhood Precursors for Adulthood Metabolic Syndrome

The goal of this study is to evaluate risk factors in children including, the development of obesity and comorbidities that predict the occurrence of metabolic syndrome in adulthood.


Co-Investigator R01 HL088567 (Couch) NIH   2/01/2008 - 1/31/2009

Modifying Dietary Behavior in Adolescents with Elevated Blood Pressure

This clinical trial is designated to evaluate the safety and efficacy of the DASH diet for lowering blood pressure in adolescents with primary hypertension. 


Co-Investigator R01 DK59183 (Dolan) NIH   9/30/2000 - 9/29/2010

Landmarks in the Progression to Type II Diabetes          

To document in a community-based study the progression through the stages of developing diabetes and risk factors associated with the development of insulin resistance, glucose intolerance and diabetes in students in grades 5 through 12.


Description of Research

We have focused our research effort on understanding the early development of atherosclerosis and left ventricular hypertrophy and the risk factors involved. Specifically, we have sought to understand the role of obesity, hypertension, dyslipidemia and diabetes in increasing risk for cardiovascular disease.     


Our research has been used as the basis for the development clinical guidelines for prevention of cardiovascular disease in children and adolescents.


We have also tested a number of interventions in randomized clinical trials.  Two current studies include evaluations of different dietary approaches to weight loss in obese adolescents and the use of the DASH diet to treat hypertension in adolescent patients.


We have also focused on the study of surgical interventions for weight loss, including better understanding of improvements in cardiovascular endpoints related to these procedures. 


Most Significant Recent Publications

1.           Couch SC, Saelens BE, Levin L, Dart K, Falciglia, G, Daniels, SR.  The Efficacy of a Clinic-Based Behavioral Nutrition Intervention Emphasizing a DASH-Type Diet for Adolescents with Elevated Blood Pressure.  Journal of Pediatrics 2008:152:494-501. 

2.           Urbina, EM, Kimball, TR, McCoy, CE, Khoury, PR, Daniels, SR, Dolan, LM. Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function.  Circulation. 2009;119:2913-2919.


Primary Focus Area

§  Obesity

§  Metabolic Dysregulation

§  Co-Morbidities


Secondary Focus

§  Weight Management


Access to Specialized Populations

§  Children and adolescents with obesity, hypertension and dyslipidemia


Benefit of CNRU

The major benefit of the CNRU is the opportunity to interact with a variety of investigators


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